A Retrospective Observational Study Comparing Clinical and Microbiological Parameters of Carbapenem Sensitive and Resistant Enterobacteriaceae Infections in a Tertiary Care Centre in Kerala

Abstract

BACKGROUND The alarming rise in carbapenem Resistance (CR) among Enterobacteriaceae is posing a great threat to the humanity, all over the world. This study is intended to evaluate the CR in a tertiary care centre in Kerala. METHODS It is a retrospective observational study of one year duration, analysing the culture and sensitivity reports of various body fluids from sick patients admitted in General Hospital, Ernakulam. RESULTS The study revealed 7.4% incidence of carbapenem resistance (CR) among the isolated Enterobacteriaceae. Klebsiella species showed more CR than E. coli. Uncontrolled diabetes mellitus is a major risk factor for the patients to contract entero infections. CKD and chemotherapy contribute significantly to higher mortality. CONCLUSIONS The incidence of CR in the study population is at par with the world statistics and good diabetic control along with combination therapy of colistin and meropenem, significantly reduces mortality in infections due to CR Enterobacteriaceae.