A retrospective study of 44 patients with head and neck Castleman’s disease

Wang, Taiqin; Chen, Xiaoqiang; Chen, Wei; Shi, Liangwen; Liu, Jianzhi

doi:10.1007/s00405-021-07065-0

Cited by 3 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mantel zones were thickened with lymphocytes arranged in layers imparting onion skin appearance with reactive lymphoid hyperplasia validating the presence of hyaline vascular type of UCD. Fever, night sweets, weight loss and fatigue were the most common presenting complaints associated with the Castleman disease [ 5 ] and our patient also reported with complaint of fever, weight loss, fatigue and supraclavicular swelling from last 1.5 year. While investigating for anesthesia fitness the antibodies to HIV were also found positive that is in concordance with association of Castleman disease with HIV infection as evident from the existing literature [ 10 ].…”

Section: Discussionsupporting

confidence: 52%

“…Morphologically the disease is classified into unicentric and multicentric Castleman disease depending upon levels of lymph nodes involvement, and according to the histopathogenetic classification it is further classified into three subtypes such as hyaline vascular Castleman disease being common one followed by plasma cell Castleman disease, and human herpesvirus 8 associated Castleman disease [ 4 ]. Fever, night sweets, weight loss and fatigue were the most common presenting complaints associated with the Castleman disease [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Unicentric Castleman Disease: A Rare Diagnosis of Radiological and Histological Correlation

Maqbool

Javed

Idrees³

et al. 2022

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

Castleman disease is an uncommon nonneoplastic, lymphoproliferative disorder of that is associated with lymphadenopathy and nonclonal lymph nodes hyperplasia. It is further subdivided into two types: Unicentric Castleman disease and Multicentric Castleman disease. Unicentric Castleman disease is rare to be reported in patients having AIDS, because HIV infected patients most commonly presented with Multicentric Castleman disease and they mostly coinfected with HHV-8. Herein we reported a rare presentation of Unicentric Castleman disease with hyaline vascular variety evident Histopathologically as a preoperative diagnosis. The patient was initially managed conservatively and surgical excision (excisional biopsy) of the left cervical lymph node was than performed and sent for histopathology. The Immunohistochemistry findings were also consistent with the diagnosis of Castleman disease Hyaline vascular type as evident from left cervical lymph node excisional biopsy.

show abstract

Section: Discussionsupporting

confidence: 52%

Section: Introductionmentioning

confidence: 99%

Unicentric Castleman Disease: A Rare Diagnosis of Radiological and Histological Correlation

Maqbool

Javed

Idrees³

et al. 2022

Indian J Otolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…Several laboratory markers can be deranged in patients with Castleman disease [3,11]. In the present case, the patient had elevated C-reactive protein and erythrocyte sedimentation rate, thrombocytosis, and anemia.…”

Section: Discussionmentioning

confidence: 44%

Unicentric Castleman Disease With Systemic Symptoms: A Rare Case From Family Practice

Aljuaid¹,

Iskandar²,

Almalki³

et al. 2022

Cureus

View full text Add to dashboard Cite

Palpable lymphadenopathy is very common in children. The vast majority of cases are due to benign conditions and self-limiting diseases. Careful clinical evaluation, with thorough history taking and make a comprehensive physical examination, is essential to avoid unnecessary invasive procedures and not to misdiagnose possible serious underlying conditions. We report the case of a 9-year-old child with a lump in the right axilla that was first noticed with a swelling two months ago. The lump was not painful but its size has been gradually increasing. The symptom was associated with night sweats. However, there was no history of cough, fever, or weight loss. The child had no history of animal contact or insect bites. No recent travel or history of contact with any sick person was reported. His vaccination schedule was up-to-date. Upon examination, the patient had a smooth non-tender swelling in the right axilla. It measured around 4 x 4 cm. The overlying skin was normal with no erythema or ulceration. The swelling was mobile and was not adherent to the overlying skin. Laboratory investigation showed mild anemia, thrombocytosis, and elevated C-reactive protein level. An ultrasound examination demonstrated a well-circumscribed enlarged lymph node, measuring 3.4 cm in short axis, with an increased blood flow on color doppler. Biopsy findings showed proliferation of the follicular lymphoid tissues that were centered around penetrative vessels giving the appearance of "onion skin" in keeping with Castleman disease. Complete surgical resection of the lymph node was performed and resulted in the resolution of the systemic symptoms. Castleman disease is a rare lymphoproliferative disorder with shared histopathological features. Unicentric Castleman disease usually presents with isolated asymptomatic lymphadenopathy. However, the present case demonstrated that patients with unicentric Castleman disease may exhibit systemic constitutional symptoms similar to that of the multicentric subtype.

show abstract

“…The clinical presentations of CD are non-specific, with enlarged lymph nodes as the main feature [ 10 ], possibly accompanied by systemic symptoms. A definitive diagnosis is challenging through only clinical presentations and imaging studies.…”

Section: Discussionmentioning

confidence: 99%

Castleman Disease Presenting in the Neck: A Report of 3 Cases and a Literature Review

Jiang,

Huang,

Liu

et al. 2024

Am J Case Rep

View full text Add to dashboard Cite

Case series Patients: Male, 8-year-old • Male, 5-year-old • Female, 10-year-old Final Diagnosis: Castleman disease Symptoms: Neck masses Clinical Procedure: — Specialty: Otolaryngology Objective: Rare disease Background: Castleman’s disease (CD) is a reactive lymph node hyperplasia initially identified by Castleman in 1956. CD predominantly affects individuals 20-50 years of age, with low incidence in children. This case report describes 3 cases of CD treated in our hospital and reviews the relevant literature. The purpose of this case report was to enhance clinical understanding and treatment of CD in the head and neck in children. Case Reports: To enhance clinical understanding and improve treatment of CD in the head and neck region in children, we present the cases of 3 patients who were admitted to the hospital, primarily presenting with a neck mass. Preoperatively, the patients collectively exhibited non-specific findings. Surgical interventions were performed with Cases 1 and 3 undergoing left functional (radical) neck lymph node dissection, in contrast to Case 2, in which bilateral functional (radical) neck lymph node dissection was executed. Pathological examination confirmed the diagnosis of CD in each of the 3 patients. Following surgery, a follow-up period ranging from 3 months to 1 year revealed that all patients had successfully recovered, with no recurrence. Conclusions: Castleman disease is a rare disease in children and difficult clinical diagnosis. Some patients with unicentric Castleman disease (UCD) can be treated with surgery, and those with multicentric Castleman disease (MCD) need chemotherapy, but at present there is no widely accepted treatment plan.

show abstract

A retrospective study of 44 patients with head and neck Castleman’s disease

Cited by 3 publications

References 24 publications

Unicentric Castleman Disease: A Rare Diagnosis of Radiological and Histological Correlation

Unicentric Castleman Disease: A Rare Diagnosis of Radiological and Histological Correlation

Unicentric Castleman Disease With Systemic Symptoms: A Rare Case From Family Practice

Castleman Disease Presenting in the Neck: A Report of 3 Cases and a Literature Review

Contact Info

Product

Resources

About