A Retrospective Study of 56 Dogs with Oronasal Fistulas Associated with Periodontal Disease

Visual and histological evaluation of the effects of trafermin in a dog oronasal fistula model

“…However, tooth loss, especially of canine teeth, where oronasal fistula most often occurs, would pose appearance issues or functional problems; sometimes, the owner does not agree with the treatment. Therefore, conservative treatment without tooth extraction is implemented, but the recurrence rate is relatively high for radical treatment [16].…”

“…Since periodontitis-induced oronasal fistula mostly occurs at the palatal side of the upper canine root [16], an oronasal fistula was artificially created in a particular region in the model for this study. The CT images and histological observations confirmed maxillary bone defects in the area from the palatal to the nasal mucosa with complete penetration between them, indicating that the oronasal fistula model prepared in this study was ideal for the study of treatment methods for oronasal fistula (Fig.…”