A retrospective study of EGF and ofloxacin drops in the healing of human large traumatic eardrum perforation

Jian-Yang,; Zihan-Lou,; Yahui-Fu,; Zhengcai-Lou,

doi:10.1016/j.amjoto.2016.03.005

Cited by 12 publications

(7 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lou et al's institution also performed clinical studies of EGF in the repair of acute perforations and reported that EGF alone significantly improved the closure rate (91.4%–96.2% vs. 61.1%–85.2%, respectively) and shortened the closure time (8.9 ± 2.3 vs. 24.6 ± 9.7 days and 9.1 ± 3.9 vs. 20.6 ± 10.7 days) compared with spontaneous healing, with an average shortening of closure time by 2 weeks [ 42 , 45 ]. However, no differences were found between EGF alone and 0.3% ofloxacin eardrops in closure rate (93.5% vs. 93.2%, respectively, P = 0.19) or closure time (12.9 ± 5.3 vs. 13.3 ± 4.9 days, respectively, P = 0.84) [ 43 ]. In addition, there were no significant differences between EGF alone and Gelfoam patching in closure rate (97.8% vs. 86.7%, respectively, P = 0.039) or average closure time (11.12 ± 4.60 vs. 13.67 ± 5.379 days, P = 0.071) [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

“…However, 26 articles did not meet the inclusion criteria, and only the remaining 47 articles were included in the analysis. Of the 47 papers, 18 were experimental studies of the effects of FGF2 or EGF in repair of acute or chronic perforations [13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] (Table 1), 16 were clinical studies in human acute perforations (FGF2 in 11 and EGF in 5) [31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46] (Table 2), nine were clinical studies in human chronic perforations (FGF2 in eight and EGF in one) [47][48][49][50][51][52][53][54][55] (Table 3), and four papers examined the dose-and time-dependent effects of FGF2 or EGF on human and...…”

Section: Resultsmentioning

confidence: 99%

“…Five clinical studies of the effects of EGF on acute perforations were from China [42][43][44][45][46]; two were randomized controlled trials (RCTs), two were prospective studies, and the remaining one was a retrospective study. Only one RCT of the effects of EGF on the regeneration of human chronic perforations was found.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Lou¹,

Lou

Jiang

et al. 2021

Stem Cells International

Self Cite

View full text Add to dashboard Cite

Objective. A systematic review was conducted to compare the effectiveness and safety of fibroblast growth factor-2 (FGF2) and epidermal growth factor (EGF) for regeneration of the tympanic membrane (TM). Methods. The PubMed database was searched for relevant studies. Experimental and clinical studies reporting acute and chronic TM perforations in relation to two healing outcomes (success rate and closure time) and complications were selected. Results. A total of 47 studies were included. Five experimental studies showed closure rates of 55%–100% with FGF2 compared with 10%–62.5% in controls for acute perforations. Five experimental studies showed closure rates of 30.3%–100% with EGF and 3.6%–41% in controls for chronic perforations. Two experimental studies showed closure rates of 31.6% or 85.7% with FGF2 and 15.8% or 100% with EGF. Nine clinical studies of acute large perforations showed closure rates of 91.4%–100% with FGF2 or EGF. Two clinical studies showed similar closure rates between groups treated with FGF2 and EGF. Seven clinical studies showed closure rates of 88.9%–100% within 3 months and 58%–66% within 12 months using FGF2 in repair of chronic perforations, but only one study showed a significantly higher closure rate in the saline group compared with the FGF2 group (71.4% vs. 57.5%, respectively, P = 0.547 ). In addition, three experimental studies showed no ototoxicity associated with FGF2 or EGF. No middle ear cholesteatoma or epithelial pearls were reported, except in one experimental study and one clinical study, respectively. Conclusions. FGF2 and EGF showed good effects and reliable safety for the regeneration of TM. In addition, EGF was better for the regeneration of acute perforations, while FGF2 combined with biological scaffolds was superior to EGF for chronic perforations, but was associated with high rates of reperforation over time. Further studies are required to determine whether EGF or FGF2 is better for TM regeneration.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Lou¹,

Lou

Jiang

et al. 2021

Stem Cells International

Self Cite

View full text Add to dashboard Cite

show abstract

“…16 Jian-Yang et al too found a shorter closure time of traumatic perforations with EGF application in a retrospective review. 17…”

Section: Discussionmentioning

confidence: 99%

Effect of Epidermal Growth Factor with Silastic Scaffold on Tympanic Membrane Perforations of Chronic Otitis Media

Bhat

Desai

Hiremath

2021

Annals of Otology and Neurotology

View full text Add to dashboard Cite

Aims The burden of chronic otitis media continues to be high, especially in developing countries. The demand for corrective procedure of surgical myringoplasty, which is considered the gold standard for tympanic membrane perforations, is also growing. Hence, there is a need to innovate simpler alternative office procedures that could save effort, time, waiting period, and expenditure. Materials and Methods This prospective study of 84 patients with mucosal chronic otitis media was undertaken in a tertiary referral hospital. All patients underwent eustachian tube function test, diagnostic nasal endoscopy, and pure tone audiometry. The size of the perforation was assessed endoscopically. All perforations were freshened first with silver nitrate solution. Silastic pieces were placed medial and lateral to the perforation with epidermal growth factor gel in between. Patients were followed up for 3 months. Results The perforations were classified into three groups (healed, partially healed, and nonhealed) based on the treatment response at the end of the first and third follow-up months. Completely healed and partially healed perforations were considered as “success” and were found to be 79% in this study. Significant association was found between healing status and type of anesthesia. However, the disease stage, size of perforation, and the duration of procedure did not affect the healing status. Conclusion Silastic enhanced myringoplasty with epidermal growth factor is a simple, effective, and economical procedure that can become an alternative to surgical myringoplasty for chronic otitis media.

show abstract

“…However, healing may be delayed by infection, not keeping the canal dry, malnutrition, thermal injury, co-morbidity, very large perforation etc. In such a case some researchers found EGR and the use of ciprofloxacin ear drop to be useful in healing of medium size perforations [10,11].…”

mentioning

confidence: 99%

Traumatic Tympanic Membrane Perforation in Lokoja, Nigeria: A Review of 43 Cases

Ogah

2016

Journal of Health and Allied Sciences NU

View full text Add to dashboard Cite

Background: The tympanic membrane main function is the conduction of sound waves for effective hearing hence its perforation almost always results in initial hearing impairment of a reasonable degree. Objectives: To identify common causes, clinical presentation and management outcome of a perforated tympanic membrane. Methods: This is a three year (January 2013-December 2015) prospective hospital base study carried out in the ENT Outpatient clinic of the Federal Medical Centre, Lokoja, Nigeria. Patients were recruited by convenience sampling method after a clinical diagnosis of traumatic tympanic membrane perforation. All patients were made to have PTA for their hearing assessment during and after treatment. Results: A total of 49 patients were recruited but 6 were lost to follow up, the remaining 43 were 24 males and 19 females with a male to female ratio of 1.26:1. Age range was from 2-80years and the modal age group was 11-20years. Ear cleaning and scratching with pointed objects was the commonest cause of traumatic tympanic membrane perforation followed by slapping from assault. Pain was the most common symptom at presentation followed by hearing loss. Spontaneous healing of the membrane occurred in 6 weeks in 34.9% of the patients and with complete restoration of hearing in 96%.

show abstract

A retrospective study of EGF and ofloxacin drops in the healing of human large traumatic eardrum perforation

Cited by 12 publications

References 17 publications

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Effect of Epidermal Growth Factor with Silastic Scaffold on Tympanic Membrane Perforations of Chronic Otitis Media

Traumatic Tympanic Membrane Perforation in Lokoja, Nigeria: A Review of 43 Cases

Contact Info

Product

Resources

About