"A Retrospective Study of Insulin Resistance in Discharged and Deceased Patients"

Abstract

Introduction:In this study, the files of discharged and deceased patients were reviewed retrospectively, taking into account age and gender. Our aim; is to determine the insulin resistance of all patients by calculating the insulin and fasting blood glucose values and homa indexes in the blood serum.Methods: Obtained the information of the patients included in the study through the Hospital Information Management System (HIMS). Considering the age and gender information of discharged and deceased patients, fasting blood glucose (mg/dL), evaluated insulin (μU/mL) and Homa-index data statistically. In the study, patients with a HOMA index of ≥2.7 were considered positive for insulin resistance (IR). Obtained approval of the study from the Sakarya University Ethics Committee (date and number: 03.05.2019, E.5229). All results were presented as mean ± standard error of the mean (SEM). Statistical comparisons were made using SPSS 19.0 statistical software (SPSS, Inc., Chicago, IL). For all statistical tests, p<0.05 was considered statistically significant.Results: When comparing parameters according to death or discharge status, the glucose levels of the deceased were found to be significantly higher than those who were discharged. Detected no significant difference in insulin and homa index. There was a correlation between Homa index, insulin and glucose, as expected. While there was an important negative relationship between age and insulin (as one increases, the other decreases), there is a significant positive relationship between age and glucose (as one increases, the other increases). When evaluated only by gender, it found Homa-index and insulin were significantly higher in females than in males (discharged and deceased patients together). In those discharged, found insulin and Homa-index values of females were to be significantly higher than in males. However, found no significant difference in males and females in deceased patients. Conclusion:Notably, in all patients who deceased and were discharged, the homa-index and insulin levels were significantly higher in females than in males. On the other hand, researching this fact with more comprehensive studies will positively contribute to clinicians in their approach to patients with suspected insulin resistance.