A Retrospective Study of Lip Hemangiomas: Curative Effect of Oral Propranolol Combined with Topical Sclerotherapy

Abstract

Objective. To analyze the therapeutic effect of oral propranolol combined with sclerotherapy of lauromacrogol and triamcinolone acetonide in the treatment of lip infantile hemangiomas (IHs). Methods. We recorded the demographic characteristics and lesions of 56 patients with lip IHs. The efficacy was evaluated by Achauer grade and VAS score in this study. Nonparametric test and Spearman correlation analysis were used to identify factors that might affect the curative effect of patients, and multivariate logistic regression analysis was used to further analyze the factors that affect the prognosis of patients with lip IH. Results. All 56 patients improved without serious complications after treatment. Univariate analysis showed that the age of the patients at the time of treatment initiation, the layer, classification, and volume of IH may influence the course and outcome of treatment. The logistic regression analysis further showed that the frequency of topical sclerotherapy was affected by the age of the months at the time of treatment initiation. The final efficacy evaluation was influenced by the age at the beginning of treatment and the layer of IH. Conclusion. Oral propranolol combined with local sclerotherapy is a safe and effective method for treating lip IH. After combination therapy, the therapeutic effect of hemangiomas located in the mucosa and submucosa is better than those located in the skin and superficial subcutaneous fascia. Patients who were younger at treatment initiation received less frequencies of topical sclerotherapy and had better therapeutic effect.

Estudo retrospectivo de hemangioma infantil na cavidade bucal na primeira infância

“…Sobre a prematuridade, neste trabalho não foi possível avaliar, uma vez que no laudo histopatológico não tem informações sobre o histórico médico e gestacional. Fatores estes, no qual a literatura também cita estar relacionado a ocorrência de hemangioma (Chang et al, 2008;Jung, 2021;Ling et al, 2022;Lyssy & Puckett, 2022).…”

“…Em relação à localização observada dos HI, estão: região da coluna vertebral, subglote, trato gastrointestinal e região de cabeça e pescoço (Ling et al, 2022;Lyssy & Puckett, 2022;Yadav et al, 2022). Para esta última localização, língua, lábios e mucosa jugal são as mais acometidas (Sampaio et al, 2022) e, em raros casos, no palato duro (Dachlan et al, 2020;Ishikawa et al, 2020).…”