A Retrospective Study of Patch Test Results from 163 Patients with Stasis Dermatitis or Leg Ulcers

Dooms‐Goossens, A.; Degreef, Hugo; Parijs, M; Kerkhofs, L.

doi:10.1159/000250570

Cited by 34 publications

(9 citation statements)

References 9 publications

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“…Among 52, who previously had 1 or more positive patch test reactions, 37 (71%) still had 1 or more positive reactions at retest. Similar results was reported from Belgium, where 50 patch test‐positive patients were retested after 3–25 months and the number of positive reactions decreased by 37%, giving a reproducibility of positive reactions of 63% (2). The patch test technique used was not specified.…”

supporting

confidence: 83%

Course of contact allergy in consecutive eczema patients patch tested with TRUE Test™ panels 1 and 2 at least twice over a 12‐year period

Jensen

Andersen

2005

Contact Dermatitis

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Non-reproducibility of positive patch test reactions is common. In this retrospective study, we investigated the reproducibility of previously positive patch test reactions and the appearance of new positive reactions in a consecutive series of 264 eczema patients tested at least twice over a 12-year period using the TRUE Test standardized patch test system. Out of 297 positive reactions, 66% remained positive in a 2nd test, 10% were scored as doubtful and 24% as negative. Among the previously recorded doubtful reactions, 13% were positive in the 2nd test, 13% were again doubtful and 74% negative. In relation to the degree of patch test reactivity, 48% of the + reactions were reproducible, compared to 87% of ++ and +++ reactions. No difference in reproducibility was observed between patients tested with a short or a long-time interval between tests. With the use of the TRUE Test panels 1 and 2, methodological factors are minimized. The variation in patch test positivity may then be attributed to biological variation, which depends on several individual factors such as patch test reading, patient-related factors such as changed immunological sensitivity, regional variation of the skin on the back and the presence of more or less active dermatitis.

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supporting

confidence: 83%

Course of contact allergy in consecutive eczema patients patch tested with TRUE Test™ panels 1 and 2 at least twice over a 12‐year period

Jensen

Andersen

2005

Contact Dermatitis

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“…The reproducibility of results of simultaneous double‐testing varies by study and test substance, but ranges between 40 and 92 %[16–19]. The reproducibility for consecutive patch tests is similar, also ranging between 40 and 92 %[16, 20–25]. There have been reports, for example, that positive patch test results serving as the basis for dermatologists’ reports on the presence of an occupational disease could not be reproduced.…”

Section: Patch Testsmentioning

confidence: 99%

“New” techniques for more sensitive patch testing?

Altmeyer

Brasch

2011

J Deutsche Derma Gesell

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SummaryThe patch test is the mainstay of diagnosis in allergic contact dermatitis. In its nearly 120-year-long history, numerous efforts to standardize several methodical aspects proved successful. The aim was always to enhance the validity and reliability of patch testing. This article reviews modifications of the basic patch test technique for enhancing test sensitivity. We expand on the recently validated strip patch test, which is a modification that involves affixing tape strips to the skin and removing them prior to patch testing. Although it was first described in 1953, we proposed the first protocol for standardized performance of the "strip patch test." The protocol was then tested in studies. As a result, test sensitivity of standardized strip patch test versus patch test was increased. The protocol produced a uniform reduction in the thickness of the stratum corneum and a good inter-rater agreement. Additionally, there was evidence of a non-specific stimulation of the inflammatory epidermal system. With regard to patient history, the standardized strip patch test showed a vastly better sensitivity than the patch test with only marginally lower specificity. As a complementary measure to patch testing diagnostic accuracy could be improved significantly by performing the standardized strip patch test. Further studies are needed on the reproducibility of the standardized strip patch test.

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“…We are aware that our series is too small to allow the drawing of conclusions robust enough to settle all the many controversies which still lie around the natural history of loss of contact sensitization in man, which certainly deserves further investigation. A number of studies have been carried out in this area (Table 2; 3–19). However, despite the amount of new knowledge accumulated over recent decades in many fields of the pathomechanism of delayed‐type hypersensitivity, the rate of decline of allergic contact sensitivity still remains an intriguing question.…”

Section: Discussionmentioning

confidence: 99%

Topical immunotherapy with contact sensitizers: a model to study the natural history of delayed hypersensitivity

Mastrolonardo¹,

Lopalco

Diaferio³

2002

Contact Dermatitis

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So-called 'topical immunotherapy' (TI) is a well-established treatment modality based on the use of potent contact sensitizers, such as squaric acid dibutylester (SADBE), that are not found in the general or occupational environment of man, and do not induce cross-sensitization to other substances. Thus, unlike patients with sensitivity to other more or less commonplace allergens, subjects submitted to this treatment modality might provide useful data for the study of the natural course of contact sensitivity. On the basis of these premises, we have retrospectively reviewed 40 patients who had consecutively received TI with SADBE for severe alopecia areata and viral warts in the period 1993-2001, and returned to visit after a 1-7-year period since the last therapeutic challenge with the sensitizer. The chronological profile of loss of contact sensitization of this case cohort has been evaluated and compared to that of other series available in the literature. Provided more standardized TI application procedures are established, aim-oriented studies of the outcome of this treatment modality may bring useful data to be employed in construction of predictive models of decay of contact sensitization under conditions of antigen avoidance.

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A Retrospective Study of Patch Test Results from 163 Patients with Stasis Dermatitis or Leg Ulcers

Cited by 34 publications

References 9 publications

Course of contact allergy in consecutive eczema patients patch tested with TRUE Test™ panels 1 and 2 at least twice over a 12‐year period

Course of contact allergy in consecutive eczema patients patch tested with TRUE Test™ panels 1 and 2 at least twice over a 12‐year period

“New” techniques for more sensitive patch testing?

Topical immunotherapy with contact sensitizers: a model to study the natural history of delayed hypersensitivity

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