A Retrospective Study of the Efficacy of Albendazole and Diethylcarbamazine for the Treatment of Human Toxocariasis

Magnaval, Jean-François; Fillaux, Judith; Berry, Antoine

doi:10.3390/pathogens11070813

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…Visceral larva migrans (VLM) and ocular larva migrans (OLM) are the two major complications of this infection. However, most cases encounter toxocariasis asymptomatically as covert toxocariasis [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Toxocariasis and Its Associated Risk Factors among Adult Population in Kavar District, Fars Province, South of Iran: A Cross-Sectional Community-Based Seroepidemiological Survey

Pezeshkian

Pouryousef

Omidian

et al. 2023

Interdisciplinary Perspectives on Infectious Diseases

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Toxocariasis as a common neglected disease is the culprit of infecting all age groups. The current cross-sectional study was designed to assess the seroprevalence of toxocariasis and risk factors associated with seropositivity of Toxocara infection among the general population of adults in the Kavar district, south of Iran. A total of 1060 participants with an age range of 35 to 70 years from the Kavar region entered the study. Manual ELISA was utilized to detect anti-Toxocara-specific antibodies in their serum samples. In addition, demographic information as well as risk factors related to toxocariasis was collected from individuals who participated in the survey. The mean age of the participants was 48.9 (±7.9) years old. Out of 1060 subjects, 532 (50.2%) were men, and 528 (49.8%) were women. The overall Toxocara seroprevalence was 5.8% (61/1060). The prevalence of Toxocara seropositive cases was significantly different between males and females ( p = 0.023). The seropositive rate for Toxocara infection was also significantly higher in housewives ( p = 0.003) and subjects with learning disabilities ( p = 0.008). Multivariable logistic regression revealed that housewives (OR = 2.04, 95% CI: 1.18–3.51, p = 0.010) and subjects with learning disability (OR = 3.32, 95% CI: 1.29–8.52, p = 0.013) were at increased risk of Toxocara infection. The findings of the current study depicted a noticeable seroprevalence of Toxocara infection in the general population in the Kavar district, southern Iran. An increased risk of toxocariasis has been associated with learning disabilities and being a housewife. All of the toxocariasis-positive cases had contact with animals, at some point in their life. In perspective, it is necessary to raise awareness of this infection among the population while surveilling Toxocara infection in high-risk groups.

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Section: Introductionmentioning

confidence: 99%

Seroprevalence of Toxocariasis and Its Associated Risk Factors among Adult Population in Kavar District, Fars Province, South of Iran: A Cross-Sectional Community-Based Seroepidemiological Survey

Pezeshkian

Pouryousef

Omidian

et al. 2023

Interdisciplinary Perspectives on Infectious Diseases

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The Nematocidal Effect of Leiurus quinquestratus Scorpion Venom on Toxocara canis in Mice Model

Salama,

Elmahy

2024

J Exp Zool Pt A

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One neglected zoonotic illness is toxocariasis. There are not enough anthelmintic drugs in the market to treat low‐effectiveness toxocariasis against migrating larvae. Therefore, it is critical to find new, safe alternatives to toxocariasis treatment today. The venom of the Leiurus quinquestratus scorpion (LQV) has numerous medicinal uses. The purpose of this study was to conduct that LQV had an effect on T. canis larvae in the model of mice. Fifty male mice were divided into five groups (n = 10). Group 1 (Gp1) was the negative group, and from Gp2‐Gp5 had been infected with 800–1000 T. canis embryonated eggs. Gp2 was left as positive control, Gp3 was orally administrated with albendazole (Alb) (100 mg/kg/b.wt) for 7 consecutive days at first day post infection (pi), Gp4 was injected intra‐peritoneal (i.p) with LQV (0.03 mg/kg/b.wt) for 15 consecutive days at the first day pi, and Gp5 was given Alb/LQV in the same way and doses as Gp3 and Gp4. At the end of the experiment, at 30th pi, the blood samples were collected for evaluating the biochemical and hematological parameters. The larval count reduction in brain were evaluated, and the histopathological changes in brain and liver were detected. The results showed that, treatment with LQV or Alb/LQV combinations significantly reduced the larval burden in the brain of the infected mice with reduction percentage reached to 70, and 72%, respectively. Interestingly, LQV and Alb/LQV significantly reduced IL‐4, IL‐10, and TNF –α levels and increased IFN‐γ levels. Also, improved the liver transaminases activity, and ameliorated liver and brain architecture. Collectively, LQV may be a promising treatment for T. canis infection and albendazole alternative.

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Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments

Mengarda

Silva

et al. 2023

European Journal of Medicinal Chemistry

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A Retrospective Study of the Efficacy of Albendazole and Diethylcarbamazine for the Treatment of Human Toxocariasis

Cited by 4 publications

References 21 publications

Seroprevalence of Toxocariasis and Its Associated Risk Factors among Adult Population in Kavar District, Fars Province, South of Iran: A Cross-Sectional Community-Based Seroepidemiological Survey

Seroprevalence of Toxocariasis and Its Associated Risk Factors among Adult Population in Kavar District, Fars Province, South of Iran: A Cross-Sectional Community-Based Seroepidemiological Survey

The Nematocidal Effect of Leiurus quinquestratus Scorpion Venom on Toxocara canis in Mice Model

Toward anthelmintic drug candidates for toxocariasis: Challenges and recent developments

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