2014
DOI: 10.1016/j.parkreldis.2014.05.006
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A retrospective study of the clinical and electrophysiological characteristics of 32 patients with orthostatic myoclonus

Abstract: Objectives To review the electrophysiological and clinical characteristics of 32 patients with orthostatic myoclonus (OM), a relatively newly identified movement disorder, and compare these characteristics to those of primary orthostatic tremor (OT) patients and patients with similar gait and balance complaints without either hyperkinesia diagnosed during the same 30-month period. Methods The database of the Mayo Clinic Florida Movement Disorders Electrophysiology Laboratory (MDEL) was searched for all patie… Show more

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Cited by 36 publications
(76 citation statements)
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“…Although falling attacks had formerly been considered a possible manifestation of epilepsy, the notion was discarded because of the poor response of drop attacks to standard anticonvulsants. Because of recent reports of myoclonus responding to piracetam7 and levetiracetam,8 this approach now warrants review.…”
Section: Personal Experiencementioning
confidence: 99%
See 1 more Smart Citation
“…Although falling attacks had formerly been considered a possible manifestation of epilepsy, the notion was discarded because of the poor response of drop attacks to standard anticonvulsants. Because of recent reports of myoclonus responding to piracetam7 and levetiracetam,8 this approach now warrants review.…”
Section: Personal Experiencementioning
confidence: 99%
“…Although there are, as yet, no prospective trials evaluating the efficacy of any treatment for this condition, the related agent, levetiracetam, has similarly been used, with anecdotal success, in patients with orthostatic myoclonus 8. Given the favourable side-effect profile of both piracetam and levetiracetam, and the clinical similarities between our patients’ reports and the manifestations and patients’ experiences of other forms of myoclonus, elderly patients suffering frequent drop attacks might respond favourably to a trial of these medications.…”
Section: A Possible Treatmentmentioning
confidence: 99%
“…We read with interest the response of Dr. van Gerpen, who subsequently published a report of patients presenting with "shaking legs" [1]. The main expressed concern is diagnostic accuracy.…”
Section: Responsementioning
confidence: 99%
“…However, OT appears to evolve independently, whether isolated or associated with additional neurological disorders 14. There is controversy whether OM occurs in isolation 8,15. Unlike other forms of tremor and myoclonus, which may be present in a person’s lower limbs while a patient is standing, the orthostatic hyperkinesias are isometric phenomena; i.e., they abate or significantly attenuate when a standing individual takes weight off their legs, such as by leaning onto an object 16,17…”
Section: Introductionmentioning
confidence: 99%