A Retrospective Study of the Incidence and the Classification of Bone Marrow Disorders in the Dog at a Veterinary Teaching Hospital (1996–2004)

Weiss, Douglas J.

doi:10.1111/j.1939-1676.2006.tb01811.x

Cited by 54 publications

(39 citation statements)

References 26 publications

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“…The genesis of hematological alterations in both red and white blood cell series is often related to bone marrow disorders such as dysplasia and aplasia [13]–[14]. A detailed examination of bone marrow provides the hematopoietic status of an individual [15], thus indicating that bone marrow disorders are related to peripheral blood alterations.…”

Section: Introductionmentioning

confidence: 99%

Clinical Forms of Canine Visceral Leishmaniasis in Naturally Leishmania infantum–Infected Dogs and Related Myelogram and Hemogram Changes

et al. 2013

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Hematological analysis has limited applications for disease diagnosis in Leishmania infantum–infected dogs, but it can be very important in evaluating the clinical forms of the disease and in understanding the evolution of canine visceral leishmaniasis (CVL) pathogenesis. Recently, we demonstrated that alterations in leucopoiesis and erythropoiesis are related to clinical status and bone marrow parasite density in dogs naturally infected by L. infantum. To further characterize these alterations, we evaluated the association between the hematological parameters in bone marrow and peripheral blood alterations in groups of L. infantum–infected dogs: asymptomatic I (AD-I: serum negative/PCR+), asymptomatic II (AD-II: serum positive), oligosymptomatic (OD), and symptomatic (SD). Results were compared with those from noninfected dogs (NID). The SD group was found to present a decrease in erythropoietic lineage with concomitant reductions in erythrocytes, hemoglobin, and hematocrit parameters, resulting in anemia. The SD group also had increased neutrophils and precursors and decreased band eosinophils and eosinophils, leading to peripheral blood leucopenia. In the AD-II group, lymphocytosis occurred in both the peripheral blood and the bone marrow compartments. The SD group exhibited lymphocytosis in the bone marrow, with lymphopenia in the peripheral blood. In contrast, the AD-I group, showed no significant changes suggestive of CVL, presenting normal counts in bone marrow and peripheral blood. Our results showed for the first time that important changes in hematopoiesis and hematological parameters occur during ongoing CVL in naturally infected dogs, mainly in symptomatic disease. Taken together, our results based on myelogram and hemogram parameters enable better understanding of the pathogenesis of the anemia, lymphocytosis, and lymphopenia, as well as the leucopenia (eosinopenia and monocytopenia), that contribute to CVL prognosis.

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Section: Introductionmentioning

confidence: 99%

Clinical Forms of Canine Visceral Leishmaniasis in Naturally Leishmania infantum–Infected Dogs and Related Myelogram and Hemogram Changes

et al. 2013

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“…Dysmyelopoiesis is defined as a hematologic disorder characterized by the presence of morphologic abnormalities (i.e., dysplasia) in one or more hematologic cell lines in the blood or bone marrow (Weiss, 2006;Weiss and Wardrop, 2011). Dysmyelopoieses are divided into myelodysplastic syndromes, secondary dysmyelopoiesis and congenital dysmyelopoiesis.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Findings in Haemograms of Dachshund Puppies: Presumptive (Immunodeficiency) Familial Disease

Turinelli¹,

Gavazza

Rushig³

et al. 2012

American Journal of Animal and Veterinary Sciences

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In a litter of seven Dachshund puppies, one subject was stillborn and six presented with diffuse skin infections characterized by dermatitis, abscessation, pustules, crusts and ulcers. Two of the puppies were referred for further evaluation. One male puppy was referred at four months of age and a sister litter mate was referred two months later. A complete blood count, biochemical and histological examination were performed on these puppies to identify the pathologic process. Clinical, biochemical, haematological and histological evaluation of subjects. This report characterizes quantitative and qualitative haematological abnormalities in two puppies that resulted in a diagnosis of dysmyelopoiesis. The existence of a familial immunodeficiency syndrome was speculated. This is the first report of such a syndrome in Dachshund puppies.

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“…6,93 Myelofibrosis in dogs is most often secondary to chronic systemic inflammation, drug therapy, or nonhematopoietic neoplasia. 115 Primary myelofibrosis has only been reported in 1 dog and may therefore be a rare condition. 115 In cats, PMF has not been reported, but myelofibrosis is a well-recognized sequel of FeLV infection.…”

Section: Myeloproliferative Neoplasms-animalsmentioning

confidence: 99%

“…115 Primary myelofibrosis has only been reported in 1 dog and may therefore be a rare condition. 115 In cats, PMF has not been reported, but myelofibrosis is a well-recognized sequel of FeLV infection. 10 Mast cell neoplasms are more common in dogs than in people and can be classified within the WHO mastocytosis group.…”

Section: Myeloproliferative Neoplasms-animalsmentioning

confidence: 99%

Prognostic Markers for Myeloid Neoplasms

et al. 2010

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Myeloid neoplasms include cancers associated with both rapid (acute myeloid leukemias) and gradual (myelodysplastic syndromes and myeloproliferative neoplasms) disease progression. Percentage of blast cells in marrow is used to separate acute (rapid) from chronic (gradual) and is the most consistently applied prognostic marker in veterinary medicine. However, since there is marked variation in tumor progression within groups, there is a need for more complex schemes to stratify animals into specific risk groups. In people with acute myeloid leukemia (AML), pretreatment karyotyping and molecular genetic analysis have greater utility as prognostic markers than morphologic and immunologic phenotypes. Karyotyping is not available as a prognostic marker for AML in dogs and cats, but progress in molecular genetics has created optimism about the eventual ability of veterinarians to discern conditions potentially responsive to medical intervention. In people with myelodysplastic syndromes (MDS), detailed prognostic scoring systems have been devised that use various combinations of blast cell percentage, hematocrit, platelet counts, unilineal versus multilineal cytopenias and dysplasia, karyotype, gender, age, immunophenotype, transfusion dependence, and colony-forming assays. Predictors of outcome for animals with MDS have been limited to blast cell percentage, anemia versus multilineal cytopenias, and morphologic phenotype. Prognostic markers for myeloproliferative neoplasms (eg, polycythemia vera, essential thrombocythemia) include clinical and hematological factors and in people also include cytogenetics and molecular genetics. Validation of prognostic markers for myeloid neoplasms in animals has been thwarted by the lack of a large case series that requires cooperation across institutions and veterinary specialties. Future progress requires overcoming these barriers.

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A Retrospective Study of the Incidence and the Classification of Bone Marrow Disorders in the Dog at a Veterinary Teaching Hospital (1996–2004)

Cited by 54 publications

References 26 publications

Clinical Forms of Canine Visceral Leishmaniasis in Naturally Leishmania infantum–Infected Dogs and Related Myelogram and Hemogram Changes

Clinical Forms of Canine Visceral Leishmaniasis in Naturally Leishmania infantum–Infected Dogs and Related Myelogram and Hemogram Changes

Abnormal Findings in Haemograms of Dachshund Puppies: Presumptive (Immunodeficiency) Familial Disease

Prognostic Markers for Myeloid Neoplasms

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