A retrospective survey of fibrinolysis as an indicator of poor outcome after cardiopulmonary bypass and a possible early sign of systemic inflammation syndrome

Cvachovec, Karel; Horáček, Michal; Vislocký, I.

doi:10.1097/00003643-200003000-00007

Cited by 16 publications

(5 citation statements)

References 5 publications

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“…In contrast to the results of another thromboelastographic study that reported poor clinical outcome in fibrinolytic patients (eg. more colloid and vasopressor support, increased mortality), 22) no complications in the postoperative period (including bleeding tendency) of our probands with fibrinolysis were noticed. However, the frequency of detected hyperfibrinolysis in that retrospective on-pump study (14%) was quite similar to our results (20%).…”

Section: Discussionmentioning

confidence: 55%

Off-Pump Versus On-Pump Coronary Artery Surgery Identification of Fibrinolysis Using Rotation Thromboelastography; A Preliminary, Prospective, Randomized Study

et al. 2007

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SUMMARYThe aim of this preliminary, prospective, randomized study was to compare rotation thromboelastography (roTEG) results and D-dimer levels in off-pump versus on-pump coronary surgery in order to identify the activation of fibrinolysis.Twenty patients scheduled for coronary bypass grafting were assessed (off-pump group A, n = 10; on-pump group B, n = 10). Blood samples for roTEG examination were taken preoperatively (t 0 ), 15 minutes after sternotomy (t 1 ), on the completion of peripheral bypass anastomoses (t 2 ), and at the end of procedures (t 3 ). The time points for D-dimer levels analyses were before operation, at the end of procedures, and 24 hours later.A certain degree of roTEG signs of fibrinolysis was noticed at time t 2 in both groups and in group B these marks were quite widely, but not significantly expressed (P for intergroup differences for Lysis on Set Time at 60 and 150 minutes were P = 0.190 and P = 0.122, respectively), borderline differences were found for Maximum Clot Firmness (P = 0.082) with a lower mean value for group B (arithmetic means [95% confidence intervals] -57.7 [54.2; 61.2] mm). Completely expressed roTEG signs of hyperfibrinolysis were observed in 2 patients from group B. In group B also the highest geometric means of Ddimers (1326.0 [943.5; 1863.6] ng mL -1 ) and thus a dramatic intergroup difference (P < 0.001) were observed at the end of surgery; 24 hours later the significantly elevated Ddimer levels in both groups (A: 1070.0 [723.5; 1582.6] versus B: 1093.3 [732.0; 1632.9] ng mL -1 ) were equalized (P = 0.932). Our roTEG results display a slightly greater, but fairly subtle activation of fibrinolysis during the course of cardiopulmonary bypass, compared to off-pump cardiac surgery. (Int Heart J 2007; 48: 57-67)

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Section: Discussionmentioning

confidence: 55%

Off-Pump Versus On-Pump Coronary Artery Surgery Identification of Fibrinolysis Using Rotation Thromboelastography; A Preliminary, Prospective, Randomized Study

et al. 2007

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“…A link between coagulation–fibrinolytic cascades and inflammatory response has been reported, with fibrinolysis being identified as an indicator of the onset of systemic inflammation [ 40 ]. In addition to the well-known roles of fibrinogen in promoting platelet aggregation, increasing plasma viscosity, and causing erythrocyte aggregation [ 41 ], previous studies have shown that it is a reactive protein that indicates the acute phase of systemic inflammation, including that arising from injury and infection [ 14 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

et al. 2022

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Although the fibrinogen-to-albumin ratio (F/R ratio) has been used as an inflammation marker to predict clinical outcomes in patients with cardiovascular diseases, its association with the prognosis of patients with coronavirus disease 2019 (COVID-19) remains unclear. Electronic databases including EMBASE, MEDLINE, Google Scholar, and Cochrane Library were searched from inception to 20 June 2022. The associations of F/R ratio with poor prognosis (defined as the occurrence of mortality or severe disease) were investigated in patients with COVID-19. A total of 10 studies (seven from Turkey, two from China, one from Croatia) involving 3675 patients published between 2020 and 2022 were eligible for quantitative syntheses. Merged results revealed a higher F/R ratio in the poor prognosis group (standardized mean difference: 0.529, p < 0.001, I2 = 84.8%, eight studies) than that in the good prognosis group. In addition, a high F/R ratio was associated with an increased risk of poor prognosis (odds ratio: 2.684, I2 = 59.5%, five studies). Pooled analysis showed a sensitivity of 0.75, specificity of 0.66, and area under curve of 0.77 for poor prognosis prediction. In conclusion, this meta-analysis revealed a positive correlation between F/A ratio and poor prognostic outcomes of COVID-19. Because of the limited number of studies included, further investigations are warranted to support our findings.

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“…Additionally, there is evidence that fibrinolysis is a marker for the onset of systemic inflammation. [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial

et al. 2007

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A retrospective survey of fibrinolysis as an indicator of poor outcome after cardiopulmonary bypass and a possible early sign of systemic inflammation syndrome

Cited by 16 publications

References 5 publications

Off-Pump Versus On-Pump Coronary Artery Surgery Identification of Fibrinolysis Using Rotation Thromboelastography; A Preliminary, Prospective, Randomized Study

Off-Pump Versus On-Pump Coronary Artery Surgery Identification of Fibrinolysis Using Rotation Thromboelastography; A Preliminary, Prospective, Randomized Study

Association between Fibrinogen-to-Albumin Ratio and Prognosis of Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis

Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial

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