2006
DOI: 10.1016/j.aca.2006.01.021
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A reusable capacitive immunosensor for carcinoembryonic antigen (CEA) detection using thiourea modified gold electrode

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2006
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Cited by 89 publications
(45 citation statements)
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“…A number of immunosensors in connection with various transducers have been reported for the detection of CEA [18][19][20][21][22]. Although most of the reported CEA immunosensors have simplified the operations, shortened the assay time, and provided a good sensitivity, applications of the developed CEA immunosensors stay in the laboratorydevelopment level and have not been widely used for clinical diagnosis.…”
Section: Introductionmentioning
confidence: 99%
“…A number of immunosensors in connection with various transducers have been reported for the detection of CEA [18][19][20][21][22]. Although most of the reported CEA immunosensors have simplified the operations, shortened the assay time, and provided a good sensitivity, applications of the developed CEA immunosensors stay in the laboratorydevelopment level and have not been widely used for clinical diagnosis.…”
Section: Introductionmentioning
confidence: 99%
“…The most important step for the construction of a capacitive immunosensor is the immobilization of biomolecules on an insulating layer of the electrode surface. A self-assembled monolayer (SAM) of alkylthiol is generally employed to make such a layer on gold rod electrodes [3,6,7,16,17]. However, this technique needs several hours [3,6,7] and the use of gold rod is suffering from the difficulties of polishing steps.…”
Section: Introductionmentioning
confidence: 99%
“…In this approach, biomolecules (e.g., antibodies) are immobilized on the electrode surface. The change in the dielectric properties is measured when an analyte (e.g., antigen) binds to the biomolecule on the electrode, causing capacitance to decrease [3,6,7,17]. The most important step for the construction of a capacitive immunosensor is the immobilization of biomolecules on an insulating layer of the electrode surface.…”
Section: Introductionmentioning
confidence: 99%
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