A reversed action of the vagus on the mammalian heart

supporting

confidence: 69%

Excitation and section of the auriculo‐ventricular bundle

Cullis¹,

Dixon²

1911

“…Directly contradictory results concerning their central connexions have been obtained by a number ofworkers (for instance, compare the results obtained on cats by Dale, Laidlaw & Symons (1910), Brown & Maycock (1942) and Pannier (1946)). But it is interesting to note that, at least in guinea-pig atria, the vagal cardio-acceleration is not prevented by guanethidine (Greeff et at.…”

Section: Discussionmentioning

confidence: 99%

The inhibitory nerve fibres in the vagal supply to the guinea‐pig stomach

Campbell¹

1966

104

6. It is argued that the vagal inhibitory fibres are not susceptible to 'adrenergic neurone blockade', the observed reduction of the responses being due to some other action of bretylium.7. These differences between the vagal and perivascular inhibitory innervations of the stomach suggest that the post-ganglionic fibres in the vagal pathway and the intramural inhibitory nerves described in the guinea-pig caecum are similar.

“…The suggestion of Fran,ois-Franck [1884] of a dual origin of the cardio-accelerator fibres in the vagus, one from the upper three cervical segments of the spinal cord which ran directly to the vago-sympathetic trunk, the other from the vagal nucleus itself is thus excluded, while the conclusion of Dale et al [1910] that they must arise from the brain centres and were probably preganglionic in nature is supported.…”

Section: Cardiac Acceleration By Atropinementioning

confidence: 89%

“…Their action on the heart was shown after atropinization. Dale, Laidlaw & Symons [1910] showed in the cat that faradic stimulation of the cervical vagus after nicotine resulted in a definite cardiac acceleration which they ascribed to accelerator fibres in the vagus. Since this action persisted after chronic removal of the superior, inferior and stellate ganglia, they concluded that these fibres had a central origin.…”

Section: Methodsmentioning

confidence: 99%

The role of the vagus in the cardio‐accelerator action of atropine in sympathectomized dogs

Brouha¹,

Nowak²

1939

Freeman & Page [1937] found, in one sympathectomized dog, an accelerator effect of atropine similar to ours. We have reinvestigated this problem, and will discuss in this paper the effect of atropine on recently and chronically sympathectomized dogs. The effect of muscular exercise on the same animals will be presented in a succeeding report. METHODSSympathectomy. Dogs were sympathectomized under ether or intravenous nembutal anaesthesia in two, three, or four stages according to the technique described for the dog by Bacq, Brouha & Heymans [1934] based on the technique of Cannon, Newton, Bright, Menkin & Moore [1929] for 1 Visiting scientist of the Belgian-American Educational Foundation.