A Reversible Thermosensitive Adhesive for Retinal Implants

Tunç, Murat; Humayun, Mark S.; Cheng, Xuanhong; Ratner, Buddy D.

doi:10.1097/iae.0b013e31817b6b42

Cited by 26 publications

(16 citation statements)

References 20 publications

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“…Because the tack fixation of the epiretinal stimulator represents the key problem of biocompatibility, some research groups started to develop special coatings of the stimulator surface to gain close contact to the inner retina without any additional fixation procedures [22,23]. In rabbits, Tunc et al used plasma polymerized N-isopropyl acrylamide as a thermosensitive adhesive, whereas the approach of Roessler et al provides a biochemical fixation gained by immobilized peptide chains at the stimulator surface towards the retina.…”

Section: Discussionmentioning

confidence: 99%

Angiographic findings following tack fixation of a wireless epiretinal retina implant device in blind RP patients

Roessler

Laube

Brockmann

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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The FA findings confirm our previous results on the safety of the EPIRET3 system, which was tolerated in all patients but revealed a certain risk profile in regard to the stimulator fixation. While there was no evidence for newly occurred CME or CNV during the follow-up visits, nevertheless gliosis or even PVR reaction at the tack's fixation site suggests the need to develop alternative fixation procedures of epiretinal stimulators.

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Section: Discussionmentioning

confidence: 99%

Angiographic findings following tack fixation of a wireless epiretinal retina implant device in blind RP patients

Roessler

Laube

Brockmann

et al. 2011

Graefes Arch Clin Exp Ophthalmol

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“…Moreover, stimulating tests will be performed to determine and to evaluate stimulation thresholds of different electrodes in regard to the retinal contact of each part of the stimulator. Alternative approaches to avoid mechanical fixation tools have been described in animal experiments but were not used clinically: Thermosensitive glues and biochemical adhesion provided by immobilized peptide chains have been used in experimental settings [32,33]. In the future these approaches may help to reduce the amount of retinal tacks for fixation of large epiretinal stimulators.…”

Section: Discussionmentioning

confidence: 99%

Development of very large electrode arrays for epiretinal stimulation (VLARS)

et al. 2014

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BackgroundRetinal implants have been developed to treat blindness causing retinal degenerations such as Retinitis pigmentosa (RP). The retinal stimulators are covering only a small portion of the retina usually in its center. To restore not only central vision but also a useful visual field retinal stimulators need to cover a larger area of the retina. However, large area retinal stimulators are much more difficult to implant into an eye. Some basic questions concerning this challenge should be answered in a series of experiments.MethodsLarge area retinal stimulators were fabricated as flexible multielectrode arrays (MEAs) using silicon technology with polyimide as the basic material for the substrate. Electrodes were made of gold covered with reactively sputtered iridium oxide. Several prototype designs were considered and implanted into enucleated porcine eyes. The prototype MEAs were also used as recording devices.ResultsLarge area retinal stimulator MEAs were fabricated with a diameter of 12 mm covering a visual angle of 37.6° in a normal sighted human eye. The structures were flexible enough to be implanted in a folded state through an insertion nozzle. The implants could be positioned onto the retinal surface and fixated here using a retinal tack. Recording of spontaneous activity of retinal neurons was possible in vitro using these devices.ConclusionsLarge flexible MEAs covering a wider area of the retina as current devices could be fabricated using silicon technology with polyimide as a base material. Principal surgical techniques were established to insert such large devices into an eye and the devices could also be used for recording of retinal neural activity.

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“…Similarly to EB irradiation, plasma and ultraviolet (UV) irradiation are used as alternative approaches for producing a PIPAAm-grafted surface. With the plasma irradiation method, bovine aortic endothelial cell (BAEC) sheets were harvested from the surface by decreasing the temperature at 20 °C for 2 h [24,25,26]. The other way to graft PIPAAm is through UV irradiation, which reduces the detachment time from 1–2 h to 30 min [27,28].…”

Section: Cell Sheet Harvesting Methodsmentioning

confidence: 99%

Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering

Koo

Lee

Park

2019

IJMS

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Cell sheet engineering has evolved rapidly in recent years as a new approach for cell-based therapy. Cell sheet harvest technology is important for producing viable, transplantable cell sheets and applying them to tissue engineering. To date, most cell sheet studies use thermo-responsive systems to detach cell sheets. However, other approaches have been reported. This review provides the progress in cell sheet detachment techniques, particularly reactive oxygen species (ROS)-responsive strategies. Therefore, we present a comprehensive introduction to ROS, their application in regenerative medicine, and considerations on how to use ROS in cell detachment. The review also discusses current limitations and challenges for clarifying the mechanism of the ROS-responsive cell sheet detachment.

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A Reversible Thermosensitive Adhesive for Retinal Implants

Abstract: ppNIPAM coated implants may provide retinal adhesion in vivo without measurable ocular toxicity in the short term. Covering a retinal tear, the ppNIPAM coated implants may prevent retinal detachment.

Cited by 26 publications

References 20 publications

Angiographic findings following tack fixation of a wireless epiretinal retina implant device in blind RP patients

Angiographic findings following tack fixation of a wireless epiretinal retina implant device in blind RP patients

Development of very large electrode arrays for epiretinal stimulation (VLARS)

Recent Advances in ROS-Responsive Cell Sheet Techniques for Tissue Engineering

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