A Review an Isatin, Isatin Derivatives and their Pharmacological Activity

Abstract

Isatin or 1H-indole-2, 3-dione is an indole derivative. Isatin is an important class of heterocyclic compounds. Recently, heterocyclic compounds analogues and their derivatives have attracted strong interest in medicinal chemistry due to their biological and pharmacological properties. The structure have offered a high value of diversity that is proven useful for the development of new medicinal drugs and improved potency,less toxicity and good pharmacological activity. Isatin has a wide varity of pharmacological activities such as an antimicrobial, anticancer, antiviral, anticonvulsant, anti-inflammatory and analgesic etc. The aim of this review is to provide the recent efforts of scinentists in pharmacological screening of isatin, importants and synthesis of isatin derivatives,pharmacological action of isatin and their biological activity.

Vanillin derivatives as antiamnesic agents in scopolamine-induced memory impairment in mice

“…Research studies have demonstrated that vanillin is effective in prevention and treatment of cognitive impairment and is a good candidate to be used clinically [ 24 ]. Beula et al has reported Isatin (SWA) derivatives with anti-amnesic action [ 25 , 26 ]. In a number of studies vanillin Schiff bases have been found to have potent antioxidant and anticholinesterase activities (both in in-vitro and in-vivo studies).…”

A Comprehensive Review of the Diverse Spectrum Activity of 1,2,3‐Triazole‐linked Isatin Hybrids

“…[9] Isatin serves as a versatile platform for structural modifications, allowing alterations at various positions in its molecular structure, including N-, C2-, C3-, and aromatic rings, for exploring its pharmacological prospective against various diseases. [10,11] Due to its simplicity towards the synthesis and further diverse biological activities exhibited by its derivatives-ranging from antibacterial and anticancer to antiviral and analgesic properties [12][13][14][15][16][17][18][19] isatin holds a prominent place in medicinal chemistry. Its unique molecular structure enables easy modifications, as it can act both as an electrophile and a nucleophile, making it a valuable building block in organic synthesis.…”

“…Due to its simplicity towards the synthesis and further diverse biological activities exhibited by its derivatives–ranging from antibacterial and anticancer to antiviral and analgesic properties [12–19] isatin holds a prominent place in medicinal chemistry. Its unique molecular structure enables easy modifications, as it can act both as an electrophile and a nucleophile, making it a valuable building block in organic synthesis.…”