The DNDC (DeNitrification-DeComposition) model (version 9.5) was applied to predict the differences in transpiration and photosynthesis rates of perennial grasses (red clover and timothy), and autotrophic respiration of a sandy Spodosol. The input parameters for two growing seasons (from 1st of May to 31st of August in 2010 and 2015) contrasting in meteorological conditions were used in the modeling experiment. In 2010, the mean air temperature of the period was 14.1 ±3.3 °C and the total precipitation – 0.1796 m, while in 2015 the mean air temperature was 16.8 ±5.5 °C and the total precipitation – 0.538 m. These meteorological parameters were unfavorable for plants in 2010 and favorable in 2015. The results have shown that the DNDC model adequately predicted the weather-induced differences in total and mean transpiration rates of perennial grasses: 0.12204 m. and 0.00099 ±0.00040 m.day−1, respectively, under favorable meteorological conditions of 2015 and 0.05969 m. and 0.00049 ±0.00035 m.day−1, respectively, under unfavorable meteorological conditions of 2010. Dynamics of daily transpiration rates of plants was significantly (r = 0.34 p <0.001) correlated with soil water content only under unfavorable meteorological conditions. Mean values of simulated photosynthesis rates were equal to 84.4 ±27.9 kg.C.ha−1.day−1 in 2015 and 52.3 ±23.4 kg.C.ha-1.day−1 in 2010. There were significant differences (p <0.001) in the mean values of photosynthesis rates between the two weather scenarios. The results of one-way analysis of variance (ANOVA) have shown that the rates of autotrophic respiration were significantly (p <0.001) higher under favorable (8.14 ±2.25 kg.C.ha−1.day−1) than under unfavorable (5.17 ±2.19 kg.C.ha−1.day−1) meteorological conditions.