A review and primer of molecular genetic studies of anorexia nervosa

Klump, Kelly L.; Gobrogge, Kyle L.

doi:10.1002/eat.20116

Cited by 51 publications

(34 citation statements)

References 56 publications

(61 reference statements)

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“…There is growing evidence that genetic and family factors contribute to the aetiology of AN Bulik & Tozzi, 2004;Klump & Gobrogge, 2005). Family studies suggest that AN runs in families (Strober, Freeman, Lampert, Diamond, & Kaye, 2000).…”

Section: Aetiology Of Anorexia Nervosamentioning

confidence: 99%

The Concept of Body Image Disturbance in Anorexia Nervosa: An Empirical Inquiry Utilizing Patients' Subjective Experiences

et al. 2011

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Section: Aetiology Of Anorexia Nervosamentioning

confidence: 99%

The Concept of Body Image Disturbance in Anorexia Nervosa: An Empirical Inquiry Utilizing Patients' Subjective Experiences

et al. 2011

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“…Genetic animal models Despite a wealth of studies, no consistent associations between susceptibility genes and AN or BN have been reported (Klump and Gobrogge 2005). A review of genetic linkage and association studies in eating disorders is beyond the scope of the article.…”

Section: Animal Models Of Anmentioning

confidence: 99%

Relevance of animal models to human eating disorders and obesity

2008

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Background and rationale This review addresses the role animal models play in contributing to our knowledge about the eating disorders anorexia nervosa (AN) and bulimia nervosa (BN) and obesity. Objectives Explore the usefulness of animal models in complex biobehavioral familial conditions, such as AN, BN, and obesity, that involve interactions among genetic, physiologic, psychological, and cultural factors. Results and conclusionsThe most promising animal model to mimic AN is the activity-based anorexia rodent model leading to pathological weight loss. The paradigm incorporates reward elements of the drive for activity in the presence of an appetite and allows the use of genetically modified animals. For BN, the sham-feeding preparation in rodents equipped with a gastric fistula appears to be best suited to reproduce the postprandial emesis and the defects in satiety. Animal models that incorporate genes linked to behavior and mood may clarify biobehavioral processes underlying AN and BN. By contrast, a relative abundance of animal models has contributed to our understanding of human obesity. Both environmental and genetic determinants of obesity have been modeled in rodents. Here, we consider single gene mutant obesity models, along with models of obesigenic environmental conditions. The contributions of animal models to obesity research are illustrated by their utility for identifying genes linked to human obesity, for elucidating the pathways that regulate body weight and for the identification of potential therapeutic targets. The utility of these models may be further improved by exploring the impact of experimental manipulations on the behavioral determinants of energy balance.

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“…Family and twin studies have consistently demonstrated that AN is strongly familial and that the observed familiality is due primarily to genetic factors (Gorwood et al, 2003). These findings led to a great increase in molecular genetic studies (Klump and Gobrogge, 2005). Most studies focused on the serotonin system, but other candidate genes have been studied, including genes involved in the regulation of feeding and energy (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…neuropeptide Y, leptin, agouti-related protein (AgRP) and Brain Derived Neurotrophic Factor (BDNF), (cf. Klump and Gobrogge (2005)). The role of these genes in the etiology of AN is still hypothetic as these studies have rarely been replicated.…”

Section: Introductionmentioning

confidence: 99%