A REVIEW: ANIMAL MODELS FOR SCREENING ANTIEPILEPTIC DRUGS & IMPORTANT UNANI ANTICONVULSANT DRUGS

Abstract

Pentylenetetrazole (PTZ) test, kindling animal model, strychnine model etc. These models can be either in vivo or in vitro, mechanism specific, mechanism independent, or seizure specific. The present article explains the types of experimental models used for screening of anticonvulsant activity of traditional drugs and some important scientifically proved Unani anticonvulsant drugs.

GABA content and an antioxidant profile positively correlated with the anticonvulsive activity of Microcos paniculata in acute seizure mice

“…Then each mouse was placed in an isolated plexiglas chamber and observed for the following 30 min for the onset and duration of convulsions and the mortality rate. Seizures were defined according to the Racine scale with minor modifications [ [24] , [25] , [26] ]. Seizure severity was measured up to the point where the maximal effect was reached using the following stages: stage 1: fictive scratching; stage 2: tremors, head nodding; stage 3: forelimb clonus; stage 4: continuous rearing, falling; stage 5: tonic-clonic seizures with hind limb extension, stupor, or jumping.…”