A Review: Detecting Alterations of Brain Connectivity in Schizophrenia based on Structural MRI

Abstract

Schizophrenia is a common psychiatric disease with brain connectivity changed. Nowadays brain network has become an effective tool to detect the abnormal brain connectivity in patients. Compared with studies focused on functional and white matter connectivity, the research of grey matter connectivity is relatively less and should be paid more attention. The primary approach of grey matter connectivity analysis is based on brain network constructed from structural MRI (sMRI). There are several morphometric features such as cortical thickness, volume, and curvature etc. Which could be used for sMRI brain network construction? This review briefly introduced sMRI brain network construction and analysis, presenting the most frequently used morphometric features with their effectiveness in schizophrenia, highlighting the application of sMRI brain network in schizophrenia, and finally estimated its potential value.