A review focusing on the benefits of plant-derived polysaccharides for osteoarthritis

Kuang, Shi-da; Liu, Lumei; Hu, Zongren; Luo, Ming; Fu, Xiouhua; Lin, Chengxiong; He, Qinchuan

doi:10.1016/j.ijbiomac.2022.12.153

Cited by 11 publications

(5 citation statements)

References 86 publications

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“…However, despite the numerous advantages revealed by several clinical trials, PP utilization in real-world medical settings remains limited. While their safety, effectiveness, and minimal side effects have been verified ( Yang et al, 2022 ; Kuang et al, 2023 ), unresolved issues persist. For example, the health benefits and medicinal value of Ganoderma lucidum polysaccharide (GLP) have been widely recognized in the academic community.…”

Section: Discussionmentioning

confidence: 99%

The roles and potential mechanisms of plant polysaccharides in liver diseases: a review

Wei,

Luo,

et al. 2024

Front. Pharmacol.

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Plant polysaccharides (PP) demonstrate a diverse array of biological and pharmacological properties. This comprehensive review aims to compile and present the multifaceted roles and underlying mechanisms of plant polysaccharides in various liver diseases. These diseases include non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), fibrosis, drug-induced liver injury (DILI), and hepatocellular carcinoma (HCC). This study aims to elucidate the intricate mechanisms and therapeutic potential of plant polysaccharides, shedding light on their significance and potential applications in the management and potential prevention of these liver conditions. An exhaustive literature search was conducted for this study, utilizing prominent databases such as PubMed, Web of Science, and CNKI. The search criteria focused on the formula “(plant polysaccharides liver disease) NOT (review)” was employed to ensure the inclusion of original research articles up to the year 2023. Relevant literature was extracted and analyzed from these databases. Plant polysaccharides exhibit promising pharmacological properties, particularly in the regulation of glucose and lipid metabolism and their anti-inflammatory and immunomodulatory effects. The ongoing progress of studies on the molecular mechanisms associated with polysaccharides will offer novel therapeutic strategies for the treatment of chronic liver diseases (CLDs).

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Section: Discussionmentioning

confidence: 99%

The roles and potential mechanisms of plant polysaccharides in liver diseases: a review

Wei,

Luo,

et al. 2024

Front. Pharmacol.

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“…Prior research indicates that plant polysaccharides exhibit multi-target and multi-pathway characteristics [ 45 ]. Given the close association of polysaccharides with the energy metabolism of organisms [ 46 , 47 ], we developed a chronic inflammatory injury cell model using C28 chondrocytes TNFα induction, subsequently intervening with SP for a duration of 10 days.…”

Section: Discussionmentioning

confidence: 99%

Sargassum polysaccharide attenuates osteoarthritis in rats and is associated with the up-regulation of the ITGβ1-PI3K-AKT signaling pathway

Liu,

Lin,

Fang

et al. 2024

Journal of Orthopaedic Translation

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“…[38][39][40] Plant-derived polysaccharides and their derivatives are among the most widely examined natural bioactive materials, due to their good safety, broad availability, and multiple bioactivities (including anti-inflammatory, antioxidant, and anti-apoptotic effects). [41][42][43][44][45] Nevertheless, these natural antiinflammatory agents generally show relatively low intrinsic efficacy, mainly due to their limited absorption and low bioavailability. Consequently, polysaccharide derivatives of diverse structures have been synthesized to afford bioactive materials with potent anti-inflammatory effects, such as glycopolymers, glycoproteins, glycosaminoglycan, and polyethyleneimineconjugated polysaccharides, [46][47][48][49] which can inhibit proinflammatory cytokine production as well as inhibit activation of macrophages and neutrophils.…”

Section: Different Anti-inflammatory Nanotherapies Based On Bioactive...mentioning

confidence: 99%

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

Li,

Chen,

et al. 2023

Advanced NanoBiomed Research

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Despite remarkable advances in understanding the mechanisms underlying inflammation, the currently available anti‐inflammatory therapies have many limitations, such as poor efficacies, low selectivity, and severe adverse effects. Bioactive materials with intrinsically anti‐inflammatory activities have emerged as promising drug candidates for the treatment of inflammatory disorders. Among them, nanotherapies based on bioactive cyclodextrin (CD) materials have attracted much attention, owing to their multiple advantages, including broad availability, well‐controlled structures, easy functionalization, good processibility, high cost‐effectiveness, and excellent biocompatibility. This review provides a comprehensive overview of the recent advancements in the development and applications of anti‐inflammatory nanoparticles (NPs) based on bioactive CD materials, with special focus on reactive oxygen species‐scavenging NPs and NPs capable of regulating inflammatory cell recruitment and activation. In addition, the applications of these anti‐inflammatory nanotherapies in the treatment of different acute/chronic inflammatory diseases are highlighted. Furthermore, major challenges in the clinical translation of these new generation anti‐inflammatory therapies derived from bioactive CD materials are discussed.

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A review focusing on the benefits of plant-derived polysaccharides for osteoarthritis

Cited by 11 publications

References 86 publications

The roles and potential mechanisms of plant polysaccharides in liver diseases: a review

The roles and potential mechanisms of plant polysaccharides in liver diseases: a review

Sargassum polysaccharide attenuates osteoarthritis in rats and is associated with the up-regulation of the ITGβ1-PI3K-AKT signaling pathway

Anti‐Inflammatory Nanotherapies Based on Bioactive Cyclodextrin Materials

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