A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders

Xin, Qiqi; Yuan, Rong; Shi, Weili; Zhu, Zhengchuan; Wang, Yan; Cong, Weihong

doi:10.1016/j.lfs.2019.116925

Cited by 74 publications

(31 citation statements)

References 84 publications

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“…Excessive inflammation can lead to chronic or systemic inflammatory diseases. In the past few decades, the prevalence of inflammatory diseases has been on the rise, especially in developed countries (Xin et al, 2019). Rosmarinic acid is a class of aqueous phenolic compounds.…”

Section: Resultsmentioning

confidence: 99%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the antiinflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a water-soluble phenolic compound that is an ester of caffeic acid and 3, 4dihydroxyphenyl lactic acid. It is discovered in many plants, like those of the Boraginaceae and Lamiaceae families. RosA has a wide range of pharmacological effects, including antioxidative, anti-apoptotic, anti-tumorigenic, and anti-inflammatory effects. The antiinflammatory effects of RosA have been revealed through in vitro and in vivo studies of various inflammatory diseases like arthritis, colitis, and atopic dermatitis. This article mainly describes the preclinical research of RosA on inflammatory diseases and depicts a small amount of clinical research data. The purpose of this review is to discuss the antiinflammatory effects of RosA in inflammatory diseases and its underlying mechanism.

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Section: Resultsmentioning

confidence: 99%

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

et al. 2020

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“…Interestingly, in addition to excellent antitumour activity directly, paeoniflorin also plays important roles in the management of some immune diseases, including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), psoriasis and asthma. [86] At the same time, modern pharmacological studies have proved that paeoniflorin has anti-inflammatory and immunosuppressive effects, which are realized by a variety of ways. Jia et al [87] found that paeoniflorin could reduce the levels of inflammatory factors such as tumour necrosis factor-a (TNF-a), interleukin (IL)-1b and IL-6 in the serum of arthritis rats and improve the symptoms of arthritis.…”

Section: Human Cervical Carcinoma Cell Line Lelamentioning

confidence: 99%

“…Increasing works have demonstrated that anti‐inflammation and immunosuppression are beneficial for cancer treatment. Interestingly, in addition to excellent antitumour activity directly, paeoniflorin also plays important roles in the management of some immune diseases, including rheumatoid arthritis (RA), inflammatory bowel disease (IBD), psoriasis and asthma . At the same time, modern pharmacological studies have proved that paeoniflorin has anti‐inflammatory and immunosuppressive effects, which are realized by a variety of ways.…”

Section: Other Related Bioactivities Of Paeoniflorinmentioning

confidence: 99%

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

Xiang

Zhang

Wei

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Paeoniflorin, a representative pinane monoterpene glycoside in plants of Paeoniaceae family, possesses promising anticancer activities on diverse tumours. This paper summarized the advance of Paeoniflorin on cancers in vivo and in vitro, discussed the related molecular mechanisms, as well as suggested some perspectives of the future investigations. Key findings Anticancer activities of paeoniflorin have been comprehensively investigated, including liver cancer, gastric cancer, breast cancer, lung cancer, pancreatic cancer, colorectal cancer, glioma, bladder cancer and leukaemia. Furthermore, the potential molecular mechanisms corresponding to the antitumour effects of Paeoniflorin might be related to the following aspects: inhibition of tumour cell proliferation and neovascularization, induction apoptosis, and inhibition of tumour invasion and metastasis. Summary Paeoniflorin has wide spectrum antitumour activities; however, in vivo and clinical investigations on antitumour effect of Paeoniflorin are lacking which should be focused on further studies. Our present review on antitumour effects of Paeoniflorin would be beneficial for the further molecular mechanisms study, candidate antitumour drug development and clinical research of Paeoniflorin in the future.

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“…The results suggest that OA can improve the inflammation present in colitis, inhibiting Th17 cell differentiation and increasing Treg cell differentiation [92]. Figure 10) is a monoterpene glycoside purified from the Chinese herb Paeonia lactiflora, with various biological activities described as anti-cancer activity [94], reduced blood viscosity [95] and anti-inflammatory activity [96]. The induction of paeoniflorin (50 mg/kg, p.o.)…”

Section: Oleanolic Acidmentioning

confidence: 99%

Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review

et al. 2020

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Inflammatory bowel diseases (IBDs) refer to a group of disorders characterized by inflammation in the mucosa of the gastrointestinal tract, which mainly comprises Crohn’s disease (CD) and ulcerative colitis (UC). IBDs are characterized by inflammation of the intestinal mucosa, are highly debilitating, and are without a definitive cure. Their pathogenesis has not yet been fully elucidated; however, it is assumed that genetic, immunological, and environmental factors are involved. People affected by IBDs have relapses, and therapeutic regimens are not always able to keep symptoms in remission over the long term. Natural products emerge as an alternative for the development of new drugs; bioactive compounds are promising in the treatment of several disorders, among them those that affect the gastrointestinal tract, due to their wide structural diversity and biological activities. This review compiles 12 terpenes with intestinal anti-inflammatory activity evaluated in animal models and in vitro studies. The therapeutic approach to IBDs using terpenes acts basically to prevent oxidative stress, combat dysbiosis, restore intestinal permeability, and improve the inflammation process in different signaling pathways.

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A review for the anti-inflammatory effects of paeoniflorin in inflammatory disorders

Cited by 74 publications

References 84 publications

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

A Review of the Anti-Inflammatory Effects of Rosmarinic Acid on Inflammatory Diseases

Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities

Intestinal Anti-Inflammatory Activity of Terpenes in Experimental Models (2010–2020): A Review

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