A review for the neuroprotective effects of andrographolide in the central nervous system

Lu, Jiashu; Ma, Yao‐Ying; Wu, Jingjing; Huang, Haoyue; Wang, Xiaohua; Chen, Zhuo; Chen, Jinliang; He, Haiyan; Huang, Chao

doi:10.1016/j.biopha.2019.109078

Cited by 95 publications

(65 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…including Parkinson's disease and Alzheimer's disease [14,15]. In our study, administration of GDL or penicillamine increased proliferation and suppressed apoptosis in the hippocampal region.…”

Section: Discussionsupporting

confidence: 53%

GanDouLing promotes proliferation and differentiation of neural stem cells in the mouse model of Wilson’s disease

Tang

Jiang

et al. 2021

Bioscience Reports

View full text Add to dashboard Cite

Wilson's disease (WD) is an autosomal recessive disease caused by mutation of the ATPase copper transporting beta (ATP7B) gene, resulting in abnormal copper metabolism. We aimed to investigate the protective effect of GanDouLing (GDL) on neural stem cell (NSC) function in a mouse model of WD. NSCs were treated with different concentrations of GDL alone or in combination with penicillamine, following which we evaluated cellular growth, apoptosis, and differentiation. Nuclear factor E2-related factor 2 (Nrf2) pathway and NOD-like receptor family pyrin domain-containing 3 (NLRP3) inﬂammasome activation were analyzed via Western blotting. Treatment with GDL alone or in combination with penicillamine significantly increased proliferation and inhibited apoptosis of NSCs in a dose-dependent manner. In addition, GDL treatment remarkably promoted differentiation of NSCs. Consistently, levels of class III β-tubulin (Tuj1) and microtubule-associated protein 2 (MAP2) were signiﬁcantly elevated, whereas glial fibrillary acidic protein (GFAP) levels were obviously suppressed in the presence of GDL or penicillamine. In vivo assays confirmed that GDL increased the ratio of Ki67+, Tuj1+, and MAP2+ cells and suppressed apoptosis in the hippocampal region in WD mice. Behavioral assays revealed that both GDL and penicillamine improved memory ability in WD models. Mechanistically, GDL treatment led to activation of Nrf2 signaling and suppression of the NLRP3 inﬂammasome in WD mice. Notably, inhibition of Nrf2 signaling reversed the protective effects of GDL on hippocampal NSCs. Collectively, these findings demonstrate that GDL exerts a protective effect on NSCs and promotes neurogenesis by targeting Nrf2 signaling and the NLRP3 inﬂammasome in WD.

show abstract

Section: Discussionsupporting

confidence: 53%

GanDouLing promotes proliferation and differentiation of neural stem cells in the mouse model of Wilson’s disease

Tang

Jiang

et al. 2021

Bioscience Reports

View full text Add to dashboard Cite

show abstract

“…In this context, we decided to study whether an activator of the Wnt canonical signaling could reestablish the protein levels and activity of Wnt components in adult animals, where the first alterations begin. In this regard, ANDRO, a bioactive molecule extracted from a medicinal plant used as pain-killer in China called Andrographis paniculata , is able to cross the blood brain barrier and therefore has been highly studied previously in our laboratory ( Lu et al, 2019 ). Our results indicate that ANDRO activates Wnt signaling pathway through direct inactivation of the enzyme GSK3β ( Tapia-Rojas et al, 2015 ).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the treatment of aged O. degus with ANDRO has shown protection from several aspects of AD-pathogenesis: i.e., decreased Aβ accumulation and lower tau phosphorylation, recovery of synaptic protein loss and cognitive impairment ( Serrano et al, 2014 ; Rivera et al, 2016 ). Moreover, several studies using ANDRO treatments had reported other effects such as adult neurogenesis ( Varela-Nallar et al, 2016 ), neurite out-growth ( Xu et al, 2019 ), and neuroprotection ( Lindsay et al, 2020 ), along with decreased neuroinflammation, oxidative stress, and synaptic dysfunction in aged animals ( Serrano et al, 2014 ; Lu et al, 2019 ; Zolezzi and Inestrosa, 2019 ; Lindsay et al, 2020 ). Specifically, ANDRO activates Wnt signaling pathway by inhibiting directly GSK-3β ( Tapia-Rojas et al, 2015 ), but also it has been described as a modulator of other cellular signaling including the BACE1-dependent amyloid processing, the Nrf2-mediated p62, the Keap1/Nrf2/ARE/HO-1, the PI3K-Akt, and the NF-kB pathways ( Seo et al, 2017 ; Gu et al, 2018 , 2019 ; Panche et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Wnt Signaling Pathway Dysregulation in the Aging Brain: Lessons From the Octodon degus

Inestrosa

Tapia-Rojas

Lindsay

et al. 2020

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Wnt signaling constitutes a fundamental cellular and molecular pathway, necessary from proper embryogenesis to function-maintenance of fully developed complex organisms. In this regard, Wnt pathway plays a crucial role in both the development of the central nervous system and in maintaining the structure and function of the neuronal circuits, and it has been suggested that its dysregulation is critical in the onset of several pathologies including cancer and neurodegenerative disorders, such as Alzheimer’s disease (AD). Due to its relevance in the maintenance of the neuronal activity and its involvement in the outbreak of devastating diseases, we explored the age-related changes in the expression of Wnt key components in the cortex and hippocampus of 7 to 72-months-old Octodon degus ( O. degus ), a Chilean long-living endemic rodent that has been proposed and used as a natural model for AD. We found a down-regulation in the expression of different Wnt ligands (Wnt3a, Wnt7a, and Wnt5a), as well as in the Wnt co-receptor LRP6. We also observed an increase in the activity of GSK-3β related to the down-regulation of Wnt activity, a fact that was confirmed by a decreased expression of Wnt target genes. Relevantly, an important increase was found in secreted endogenous Wnt inhibitors, including the secreted-frizzled-related protein 1 and 2 (SFRP-1 and SFRP-2) and Dickkopf-1 (Dkk-1), all them antagonists at the cell surface. Furthermore, treatment with Andrographolide, a labdane diterpene obtained from Andrographis paniculata , prevents Wnt signaling loss in aging degus . Taken together, these results suggest that during the aging process Wnt signaling activity decreases in the brain of O. degus .

show abstract

“…is widely used as medicinal herb in traditional medicine [1][2][3]. Diterpenoid lactones isolated from these extracts have been the subject of intensive investigations and are reported to exhibit a wide spectrum of biological activities, including antibacterial [4], anti-inflammatory [5][6][7][8], hepatoprotective [9][10][11], neuroprotective [12], cardioprotective [13,14] and anticancer properties [15,16]. Andrographolide 1 (Figure 1) has been reported to be the main active compound in the plant [17,18].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Determination of Andrographolide and Related Compounds in Andrographis paniculata Extracts and Biological Evaluation of Their Anti-Inflammatory Activity

Villedieu-Percheron

Ferreira

Campos

et al. 2019

Foods

View full text Add to dashboard Cite

Extraction, isolation and characterization of Andrographis paniculata (A.p.) products were developed. Three natural diterpenes compounds were obtained and one was used for chemical modifications. Evaluation of their inhibition of TNFα induced NFκB transcriptional activity. A rapid analytical method for the determination and quantitation of three diterpenoid lactones (andrographolide 1, didehydroandrographolide 2, neoandrographiside 3) found in A. paniculata extracts was investigated. After some optimizations on column type and injection solvent, the separation was achieved in 9 min on a monolithic Chromolith Performance RP18e column (100 mm × 4.6 mm ID, 2 µm), with a gradient solvent system of water and methanol, UV detection at 220 nm and ELSD detection. The method was proved to be suitable for the quantitation of these three diterpenes in four different commercial Andrographis dietary supplements. The anti-inflammatory activities of a mixture of known composition have been evaluated showing differences in activity depending on the relative ratio of various diterpenes and also a possible synergic activity for some of them.

show abstract

A review for the neuroprotective effects of andrographolide in the central nervous system

Cited by 95 publications

References 104 publications

GanDouLing promotes proliferation and differentiation of neural stem cells in the mouse model of Wilson’s disease

GanDouLing promotes proliferation and differentiation of neural stem cells in the mouse model of Wilson’s disease

Wnt Signaling Pathway Dysregulation in the Aging Brain: Lessons From the Octodon degus

Quantitative Determination of Andrographolide and Related Compounds in Andrographis paniculata Extracts and Biological Evaluation of Their Anti-Inflammatory Activity

Contact Info

Product

Resources

About