A Review From Historical to Current-Celastrus Paniculatus

Abstract

Celastrus paniculatus is commonly known as “Malkangani”, widely distributed in the Maldives, Australia, China, Cambodia, Malaysia, Taiwan, Nepal, Thailand as well as in the Pacific Islands and all over India mainly Maharashtra, Orissa and Andaman and Nicobar group of Islands on an altitude of 1800m. It climbs up to over 10m. The leaves are ovate or elliptic in shape with dentate margin. Seeds are ellipsoid or ovoid, yellowish-brown in color and grow inside the capsules. Celastrus paniculatus (Malkangni) is used in Ayurveda as a nervine tonic, tranquilizer and diuretic and in rheumatism, gout, leprosy and asthma. Different Parts of Celastrus paniculatus after extraction and fractionation give different active constituents such as sesquiterpene esters-malkanguinol, malkangunin, sesquiterpene alkaloids-celapanin, celapanigin, alkaloids-celastrine, paniculatine, fatty acids-oleic acid, palmittic acid, linoleic acid and stearic acid, crystalline substance tetracasanol and sterol. Different pharmacological activities are anti-rheumatic, anti-fungal, nootropic activity, antimalarial activity, anti spermatogenic effect, anti-anxiety and anti-atherosclerotic effect. In the present review, our target is to search, bring together and compile the data of Celastrus paniculatus, which have less side effects and very valuable for the treatment of rheumatism. Related information is procured from various scientific publications using online, seek out engines such as Google scholar, Pubmed and Science Direct. A total of 200 articles was reviewed out of which 55 articles are selected to review for the description of the plant, parts used, chemical constituents, traditional uses and for reported activities.

Nootropic Effect of Celastrus paniculatus on Restraint Stress Induced Behavioral and Biochemical Changes in Wistar Albino Rats

“…Free radicals, which are responsible for the formation of oxidative stress, are the key contenders for causing the neural alterations driving these behavioral abnormalities (28,29). In order to avoid oxidative damage and enhance memory, there is growing interest in the biochemical activity of natural antioxidants found in fruits, vegetables, and medicinal plants (30).…”

An overview of Indian herbs with the potential in the treatment of the Alzheimerrsquo;s disease

“…Traditional functional feature: Celastrus paniculatus, often known as Malkangani or Jyotishmati, belongs to the Celastraceae family. Celastrus paniculatus is used in Ayurvedic medicine as a nervine tonic, tranquilizer, and diuretic, as well as to treat rheumatism, gout, leprosy, and asthma [64] . It is an Indian medicinal plant that plays an important role in the Ayurvedic medical system.…”

“…radical scavenging activity, inhibits the activity of authentic peroxynitrite (ONOO-), and inhibits the formation of total reactive oxygen species (ROS). Pristemerin [64,65,66,67] 18.…”

Untitled

“…Its rough, pale brown exfoliating bark is covered heavily in small, elongated lenticles and its seeds are completely encased in red arillus, which are ovoid in shape and brown in colour. It contains chemical constituents, including Alkaloids, sterols, triterpenoids, fatty acids, tannins, saponins and phenolic compounds 5 . It possesses various pharmacological activities such as Anti-Alzheimer, nootropic, anti-arithmetic, wound healing, antioxidant, antibacterial and antiviral 6 .…”