A review of Acanthopanax senticosus (Rupr and Maxim.) harms: From ethnopharmacological use to modern application

Jia, Ailing; Zhang, Yuhang; Han, Gao Rong; Zhang, Zhen; Zhang, Yanfei; Wang, Zhe; Zhang, Jinming; Deng, Bin; Qiu, Zhidong; Fu, Chaomei

doi:10.1016/j.jep.2020.113586

Cited by 60 publications

(45 citation statements)

References 63 publications

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“…The phytochemical composition consists of phenylpropanoid-syringin; lignanssesamin; saponins-daucosterol; coumarins, terpenoids, flavonoids, organic acids, and vitamins [44,45]. Extracts of Eleutherococcus senticosus root are obtained, stimulating the immune system, influencing adaptation against external factors, improving mental and physical conditions and memory functions, and have a hypoglycaemic effect and are antiinflammatory [13,45,46]. Eleutherococcus senticosus is thought to exert its adaptogenic effects by influencing the hypothalamic-pituitary-adrenal axis [44].…”

Section: Eleutherococcus Senticosusmentioning

confidence: 99%

Plant Adaptogens—History and Future Perspectives

et al. 2021

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Adaptogens are synthetic compounds (bromantane, levamisole, aphobazole, bemethyl, etc.) or plant extracts that have the ability to enhance the body’s stability against physical loads without increasing oxygen consumption. Extracts from Panax ginseng, Eleutherococcus senticosus, Rhaponticum carthamoides, Rhodiola rosea, and Schisandra chinensis are considered to be naturally occurring adaptogens and, in particular, plant adaptogens. The aim of this study is to evaluate the use of plant adaptogens in the past and now, as well as to outline the prospects of their future applications. The use of natural adaptogens by humans has a rich history—they are used in recovery from illness, physical weakness, memory impairment, and other conditions. About 50 years ago, plant adaptogens were first used in professional sports due to their high potential to increase the body’s resistance to stress and to improve physical endurance. Although now many people take plant adaptogens, the clinical trials on human are limited. The data from the meta-analysis showed that plant adaptogens could provide a number of benefits in the treatment of chronic fatigue, cognitive impairment, and immune protection. In the future, there is great potential to register medicinal products that contain plant adaptogens for therapeutic purposes.

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Section: Eleutherococcus Senticosusmentioning

confidence: 99%

Plant Adaptogens—History and Future Perspectives

et al. 2021

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“…Importantly, eleuthero root extract is safe and exerts no significant adverse effects at normal doses. [67,68] E. senticosus has long been used as a potent immunomodulator, an anti-inflammatory agent and an anti-rheumatic agent in oriental medicine. Jung et al [69] assessed the protective efficacy of E. senticosus root extract on the expression of iNOS and COX-2 in LPS-activated macrophages, as well as investigated its involvement in MAPKs and Akt signaling pathways.…”

Section: Water Extract Of Rosa Canina (Family Rosaceae) (A Novel Natural Source Of Citrus Bioflavonoids From Rose Hips)mentioning

confidence: 99%

Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

Downs¹,

Banik²,

Bagchi

et al. 2021

AJBPS

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An increase in anaerobic (oxygen-deprived) pathogenesis significantly increases the generation of reactive oxygen species (ROS) inflicting damage on cell membranes and intracellular constituents. Generation of ROS and concomitant inflammatory response is the two hallmarks of cellular damage caused by cellular injury or invasion by pathogens. Oxygen deprivation, as opposed to oxygen deficiency, is a major contributor to oxidative stress and damage, cytokine production, and inflammation. When our cells are unable to efficiently and effectively utilize the oxygen to facilitate aerobic glycolysis and other cellular metabolic events, the oxygen instead oxidizes cell membranes, lipids, neurons, cross-links proteins, damages DNA, and initiates inflammation among other consequences. These anaerobic events are hallmarks of chronic degenerative diseases (CDD). Excessive demands to curtail oxidative damage can overburden endogenous antioxidative capabilities. A key treatment strategy to tackle the adverse effects of inflammation involves the augmentation of the structural integrity and functional competence of cellular materials, reducing the impact and consequences of tissue insult; the generation of ROS; and the cascade of subsequent pathological disorders. Moreover, restoration of cellular aerobic metabolic events, such as aerobic glycolysis and oxidative respiration, is an equally important collateral goal. A healthy diet and supplementation, providing an abundance of exogenous sources of antioxidants and a host of phytochemical dietary components, becomes even more important to restore aerobic metabolism; augment and assist in improving cellular structural integrity, and thereby reducing oxidative stress, damage, and inflammatory sequela. VMP35 MNC, a research-affirmed Prodosomed nutraceutical technology-based phytonutrient formulation, enriched in structurally diverse bioflavonoids, polyphenols, and phenolic saccharides, etc., have been shown to boost cellular structural integrity and physiological functions, and restore aerobic metabolic competence including for athletic performance as well as for general well-being. This review provides a strategic approach for the design of a novel Prodosomed VMP35 Multinutrient/phytoceutical complex and to evaluate its ability to reverse anaerobic pathologies, including inflammation, and restore healthy cellular aerobic glycolysis.

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“…Acanthopanax senticosus (AS) belongs to the family Araliacea, which is mainly distributed throughout China, Japan, and South Korea [ 1 ]. The main regions where it is produced are Liaoning, Jilin, Heilongjiang, Hebei, and Shanxi in China.…”

Section: Introductionmentioning

confidence: 99%

Adsorption and Desorption Characteristics of Total Flavonoids from Acanthopanax senticosus on Macroporous Adsorption Resins

Wang

Chu

et al. 2021

Molecules

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We examined the application of six different resins with the aim of selecting a macroporous resin suitable for purifying Acanthopanax senticosus total flavonoids (ASTFs) from Acanthopanax senticosus crude extract (EAS) by comparing their adsorption/desorption capacities, which led to the selection of HPD-600. Research on the adsorption mechanism showed that the adsorption process had pseudo-second-order kinetics and fit the Freundlich adsorption model. Moreover, the analysis of thermodynamic parameters indicated that the adsorption process is spontaneous and endothermic. The optimal conditions for purification of ASTFs were determined as sample pH of 3, 60% ethanol concentration, and 3 BV·h−1 flow rate, for both adsorption and desorption, using volumes of 2.5 and 4 BV, respectively. The application of macroporous resin HPD-600 to enrich ASTFs resulted in an increase in the purity of total flavonoids, from 28.79% to 50.57%. Additionally, the antioxidant capacity of ASTFs was higher than that of EAS, but both were lower than that of L-ascorbic acid. The changes in ASTFs compositions were determined using ultra-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS), with the results illustrating that the levels of seven major flavonoids of ASTFs were increased compared to that in the crude extract.

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A review of Acanthopanax senticosus (Rupr and Maxim.) harms: From ethnopharmacological use to modern application

Cited by 60 publications

References 63 publications

Plant Adaptogens—History and Future Perspectives

Plant Adaptogens—History and Future Perspectives

Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

Adsorption and Desorption Characteristics of Total Flavonoids from Acanthopanax senticosus on Macroporous Adsorption Resins

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