A Review of Additives for Plastics: Slips and Antiblocks

Patel, Prakash; Savargaonkar, Nilesh

doi:10.1002/j.1941-9635.2007.tb00033.x

Cited by 9 publications

(11 citation statements)

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“…Erucamide is a fatty acid amide used in plastics manufacture as an nonblocking slip agent. 6,7 We have since learned, as a result of extensive conversations with the vendor, that the 50-µL and 70-µL VPrep polypropylene tips are produced by different manufacturers. Significantly, we were also able to learn that the vendor had changed manufacturers of the 50-µL VPrep tips shortly before we began to experience problems in our compound solubility assay.…”

Section: Resultsmentioning

confidence: 99%

“…Careful testing of each component of the assay process identified one particular size of disposable pipette tip, used in the CM compound plating process for the assay, as the source of the problem. Using a combination of nuclear magnetic resonance (NMR) and gas chromatography/mass spectroscopy (GC/MS) analytical techniques, we were able to specifically extract erucamide, a fatty acid amide routinely used as a slip agent in the manufacture of certain plastic products, 6,7 from these pipette tips by DMSO. We further report that the extracts prepared from the problematic tips were also active in a cell-based functional bioassay for a G-protein-coupled receptor, as was a commercially obtained sample of erucamide.…”

Section: Introductionmentioning

confidence: 99%

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Extraction, Identification, and Functional Characterization of a Bioactive Substance From Automated Compound-Handling Plastic Tips

Watson¹,

Greenough²,

Leet³

et al. 2009

SLAS Discovery

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Disposable plastic labware is ubiquitous in contemporary pharmaceutical research laboratories. Plastic labware is routinely used for chemical compound storage and during automated liquid-handling processes that support assay development, high-throughput screening, structure-activity determinations, and liability profiling. However, there is little information available in the literature on the contaminants released from plastic labware upon DMSO exposure and their resultant effects on specific biological assays. The authors report here the extraction, by simple DMSO washing, of a biologically active substance from one particular size of disposable plastic tips used in automated compound handling. The active contaminant was identified as erucamide ((Z)-docos-13-enamide), a long-chain mono-unsaturated fatty acid amide commonly used in plastics manufacturing, by gas chromatography/mass spectroscopy analysis of the DMSO-extracted material. Tip extracts prepared in DMSO, as well as a commercially obtained sample of erucamide, were active in a functional bioassay of a known G-protein-coupled fatty acid receptor. A sample of a different disposable tip product from the same vendor did not release detectable erucamide following solvent extraction, and DMSO extracts prepared from this product were inactive in the receptor functional assay. These results demonstrate that solvent-extractable contaminants from some plastic labware used in the contemporary pharmaceutical research and development (R&D) environment can be introduced into physical and biological assays during routine compound management liquid-handling processes. These contaminants may further possess biological activity and are therefore a potential source of assay-specific confounding artifacts.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extraction, Identification, and Functional Characterization of a Bioactive Substance From Automated Compound-Handling Plastic Tips

Watson¹,

Greenough²,

Leet³

et al. 2009

SLAS Discovery

View full text Add to dashboard Cite

show abstract

“…The limitation of the barrier performance on the LDPE foils was due to the slip and anti-block agent added in the LDPE, which leads to more defects in the SiO x coating. 39 The barrier performance could be improved by cleaning the substrate, yet this was not practical for the industrial applications. 40 …”

Section: Discussionmentioning

confidence: 99%

Oxygen barrier coating deposited by novel plasma‐enhanced chemical vapor deposition

Jiang

Benter²,

Taboryski

et al. 2009

J of Applied Polymer Sci

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ABSTRACT:We report the use of a novel plasmaenhanced chemical vapor deposition chamber with coaxial electrode geometry for the SiO x deposition. This novel plasma setup exploits the diffusion of electrons through the inner most electrode to the interior samples space as the major energy source. This configuration enables a gentle treatment of sensitive materials like low-density polyethylene foils and biodegradable materials. SiO x coatings deposited in the novel setup were compared with other state of the art plasma coatings and were found to possess equally good or better barrier properties. The barrier effect of single-layer coatings deposited under different reaction conditions was studied. The coating thickness and the carbon content in the coatings were found to be the critical parameters for the barrier property. The novel barrier coating was applied on different polymeric materials, and it increased the barrier property of the modified low-density polyethylene, polyethylene terephthalate, and polylactide by 96.48%, 99.69%, and 99.25%, respectively.

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“…However, these organic anti-blocking agents are relatively expensive; hence they are used in high-value-added products. 25…”

Section: Introductionmentioning

confidence: 99%

Studying the impact of synthetic silica and cross-linked polymethyl methacrylate as anti-blocking agents on the physical properties of electric cables

Karunarathna

Premathilaka

Arachchige

et al. 2023

Journal of Elastomers & Plastics

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One of the major problems associated with the production process of cables is the tight adhesion between the insulation and jacket (blocking), which is resulted from electrostatic and Van der Waals interactions between the two polymer layers. It makes them difficult to separate without damaging the insulation. As a conventional approach, a talc layer is applied within the insulation and jacket interface to prevent the blocking between the jacket and insulation. However, maintaining a uniform talc layer is difficult, and the uneven distribution of talc particles produces a non-smooth surface. Therefore, the conventional talc layer method has limited efficiency in reducing the bocking. In this study, a surface modification was done for both the insulation and jacket using synthetic silica and crosslinked polymethyl methacrylate (PMMA). This study evaluated the effect of these two additives on other physical properties, including heat stability, insulation resistance, tensile strength, elongation at break, and pressure stability. This study reveals that the application of synthetic silica has successfully reduced the blocking between insulation and jacket and favorably contributed to increasing insulation resistance. The optimum levels of anti-blocking agents to be used in the insulation and jacket compound have also been estimated by this investigation.

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A Review of Additives for Plastics: Slips and Antiblocks

Cited by 9 publications

References 0 publications

Extraction, Identification, and Functional Characterization of a Bioactive Substance From Automated Compound-Handling Plastic Tips

Extraction, Identification, and Functional Characterization of a Bioactive Substance From Automated Compound-Handling Plastic Tips

Oxygen barrier coating deposited by novel plasma‐enhanced chemical vapor deposition

Studying the impact of synthetic silica and cross-linked polymethyl methacrylate as anti-blocking agents on the physical properties of electric cables

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