A Review of Advances in Hematopoietic Stem Cell Mobilization and the Potential Role of Notch2 Blockade

Albakri, Marwah; Tashkandi, Hammad; Zhou, Lan

doi:10.1177/0963689720947146

Cited by 10 publications

(13 citation statements)

References 173 publications

(208 reference statements)

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“…Compared with G-CSF, plerixafor-triggered HSC mobilization has clear mechanism. The interaction between Notch2 and its ligand also maintains HSC niche retention; Notch2-blocking antibodies sensitize HSCs to the mobilizing stimuli of G-CSF and plerixafor, resulting in a 3–4-fold increase in mobilization [ 30 31 32 ].…”

Section: P Roteases Released By Neutrophils Change Hematopo...mentioning

confidence: 99%

Hematopoietic stem cell mobilization

Sun

Chang

Liou

2022

Tzu Chi Medical Journal

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A BSTRACT Hematopoietic stem cell (HSC) transplantation has been used to treat hematopoietic diseases for over 50 years. HSCs can be isolated from bone marrow (BM), umbilical cord blood, or peripheral blood. Because of lower costs, shorter hospitalization, and faster engraftment, peripheral blood has become the predominant source of HSCs for transplantation. The major factors determining the rate of successful HSC transplantation include the degree of human leukocyte antigen matching between the donor and recipient and the number of HSCs for transplantation. Administration of granulocyte colony-stimulating factor (G-CSF) alone or combined with plerixafor (AMD3100) are clinical used methods to promote HSC mobilization from BM to the peripheral blood for HSC transplantations. However, a significant portion of healthy donors or patients may be poor mobilizers of G-CSF, resulting in an insufficient number of HSCs for the transplantation and necessitating alternative strategies to increase the apheresis yield. The detailed mechanisms underlying G-CSF-mediated HSC mobilization remain to be elucidated. This review summarizes the current research on deciphering the mechanism of HSC mobilization.

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Section: P Roteases Released By Neutrophils Change Hematopo...mentioning

confidence: 99%

Hematopoietic stem cell mobilization

Sun

Chang

Liou

2022

Tzu Chi Medical Journal

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“…Finally, enhanced or reduced Notch signaling can result in a variety of diseases, including liver diseases and cancers [ 6 , 125 ]. In addition, inhibition or activation of specific Notch receptors and ligand axes have been proposed as therapeutics in other diseases such as nephrosis and graft-versus-host disease [ 126 , 127 , 128 , 129 , 130 , 131 , 132 , 133 ]. A recent study by Haltiwanger and Wu labs proposed an innovative way to specifically inhibit Delta ligand-induced Notch activities using fucose-analogs [ 76 ].…”

Section: Perspectivementioning

confidence: 99%

Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions

Saiki

Okajima

et al. 2021

Biomolecules

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The 100th anniversary of Notch discovery in Drosophila has recently passed. The Notch is evolutionarily conserved from Drosophila to humans. The discovery of human-specific Notch genes has led to a better understanding of Notch signaling in development and diseases and will continue to stimulate further research in the future. Notch receptors are responsible for cell-to-cell signaling. They are activated by cell-surface ligands located on adjacent cells. Notch activation plays an important role in determining the fate of cells, and dysregulation of Notch signaling results in numerous human diseases. Notch receptors are primarily activated by ligand binding. Many studies in various fields including genetics, developmental biology, biochemistry, and structural biology conducted over the past two decades have revealed that the activation of the Notch receptor is regulated by unique glycan modifications. Such modifications include O-fucose, O-glucose, and O-N-acetylglucosamine (GlcNAc) on epidermal growth factor-like (EGF) repeats located consecutively in the extracellular domain of Notch receptors. Being fine-tuned by glycans is an important property of Notch receptors. In this review article, we summarize the latest findings on the regulation of Notch activation by glycosylation and discuss future challenges.

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“…There is an increasing demand for peripheral HPSC as it is a less invasive collection method compared to bone marrow harvesting 2 . However, the success of peripheral HPSC is reliant on obtaining an adequate number of hematopoietic stem cells to ensure satisfactory hematological reconstitution 3,4 . CD34+ is a marker of HPSC, and all colony‐forming activity of human bone marrow 5 and it is agreed that a minimum of ≥2 × 10 6 /kg CD34+ of recipient body weight is necessary for successful engraftment 6 in the autologous setting, however more cells are required in the allogenic setting.…”

Section: Introductionmentioning

confidence: 99%

“…2 However, the success of peripheral HPSC is reliant on obtaining an adequate number of hematopoietic stem cells to ensure satisfactory hematological reconstitution. 3,4 CD34+ is a marker of HPSC, and all colony-forming activity of human bone marrow 5 and it is agreed that a minimum of ≥2 Â 10 6 /kg CD34+ of recipient body weight is necessary for successful engraftment 6 in the autologous setting, however more cells are required in the allogenic setting. Although there is an agreed minimum value, the target for CD34+ can vary between institutions, type of disease and the type of transplant being performed.…”

Section: Introductionmentioning

confidence: 99%

The efficiency of a continuous versus an intermittent apheresis method for collection of hematopoietic progenitor stem cells: A systematic review

Hobbs

Green

Fernandez

2023

J of Clinical Apheresis

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Peripheral blood hematopoietic progenitor stem cells (HPSCs) are the most common source of stem cells for autologous and allogenic transplantation. Currently, systematic reviews comparing the collection efficiency of a continuous to an intermittent method are lacking despite the existence of primary studies. Therefore, the objective of this review was to synthesize the best available evidence to compare the efficiency of the continuous vs the intermittent method for the collection of hematopoietic progenitor stem cells required for HPC transplantation. A search using MEDLINE, CINAHL, EMBASE, Google scholar, and MedNar for both published and unpublished studies was conducted in December 2021. The systematic review was conducted in accordance with JBI methodology. A critical appraisal of the studies was undertaken by two independent reviewers using the JBI quasi-experimental critical appraisal checklist. A total of six studies were included in the review. The findings of this review demonstrated that there was no statistically significant difference in the collection efficiency, length of procedure time, and total blood volume processed between the continuous and intermittent programs. The evidence suggests that the continuous method is as safe and effective as the intermittent method to collect HPSCs. Until further evidence becomes available clinicians should be guided by the policies of their individual hospitals.

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A Review of Advances in Hematopoietic Stem Cell Mobilization and the Potential Role of Notch2 Blockade

Cited by 10 publications

References 173 publications

Hematopoietic stem cell mobilization

Hematopoietic stem cell mobilization

Current Views on the Roles of O-Glycosylation in Controlling Notch-Ligand Interactions

The efficiency of a continuous versus an intermittent apheresis method for collection of hematopoietic progenitor stem cells: A systematic review

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