A Review of Analytical Methods for the Estimation of Ivabradine and Metoprolol in Pharmaceutical Formulations and Biological Matrices

Abstract

The combination of Ivabradine (IVA) and Metoprolol (MET) was approved by US-FDA for symptomatic treatment of chronic stable angina pectoris. This Review focuses on recent development in analytical methods for IVA and MET. This review article represents the collection and discussion of various analytical methods available in the literature for the determination of IVA and MET individually and combination available in pharmaceutical and biological samples consisting of HPLC, HPTLC, GC, Thermal methods like TGA, DTA, DSC, and hyphenated techniques such as LC-MS, LC-MS/MS, and UPLC-MS/MS. All reported methods found to be simple, accurate, economic, precise and reproducible in nature. The present review article can be effectively explored to conduct future analytical investigation for the estimation of Ivabradine and Metoprolol.

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“…A literature review notes that a number of techniques, including LC-MS [22,24], UPLC [17,24], HPLC [7-16, 18-21, 23], and bioanalytical, have been developed for the simultaneous detection of Rilpivirine and Cabotegravir in pharmaceutical formulations and biological fluids.…”