“…This is the case of chalcones, some of which are flavonoids with antiinflammatory, antibacterial, antiviral, antitumor and antiparasitic activity. 55 Licochalcone A (LCA) is a member of this family, whose interaction with HSA and BSA has been investigated. 56,57 In homogeneous media, LCA displays three absorption maxima corresponding to the neutral (382 nm), monoanionic (401 nm) and dianionic (457 nm) forms.…”
“…This is the case of chalcones, some of which are flavonoids with antiinflammatory, antibacterial, antiviral, antitumor and antiparasitic activity. 55 Licochalcone A (LCA) is a member of this family, whose interaction with HSA and BSA has been investigated. 56,57 In homogeneous media, LCA displays three absorption maxima corresponding to the neutral (382 nm), monoanionic (401 nm) and dianionic (457 nm) forms.…”
“…Chalcones and their derivatives are interesting materials for their biological activities such as anti-viral, anti-malarial, anti-cancer, antioxidant, anti-inflammatory, antifungal, antileishmanial, anti-tubercular, anti-hyperglycemic properties [6][7][8][9][10][11]. They are also used in different applications such as agriculture [12], cosmetics and manufacture of pesticides [13].…”
“…8 They are of special interest due to their pronounced antimicrobial activities. 9,10 However, thiazole ring is found to be a common structural component in a large number of biological agents.…”
A series of novel hybrids possessing chalcone and thiazole moieties were synthesized and evaluated for their antibacterial activities. In general this class of hybrids exhibited potency against Staphylococcus aureus, and in particular, compound 27 exhibited potent inhibitory activity with respect to other synthesized hybrids. Furthermore, the hemolytic and toxicity data demonstrated that the compound 27 was nonhemolytic and nontoxic to mammalian cells. The in vivo studies utilizing a S. aureus septicemia model demonstrated that compound 27 was as potent as vancomycin. The results of antibacterial activities underscore the potential of this scaffold that can be utilized for developing a new class of novel antibiotics.
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