A Review of Associations between Externalizing Behaviors and Prenatal Cannabis Exposure: Limitations &amp; Future Directions

Ikeda, Ami S.; Knopik, Valerie S.; Bidwell, L. Cinnamon; Parade, Stephanie H.; Goodman, Sherryl H.; Palmer, Rohan

doi:10.3390/toxics10010017

Cited by 3 publications

(2 citation statements)

References 90 publications

(98 reference statements)

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“…These findings are supported by associative research from humans, and empirical research in animal models, that show that PCE impacts memory and behaviour in children and adolescents, and that this impact persists into adulthood 26 . Further, PCE is has consequences for behavioural and neurodevelopment 25 , via disruption of the developing central nervous system 36,86 , impacting neuron development and growth 87 . Moreover, PCE is associated with an increase in psychosis and psychopathology in middle childhood 24,88 , which may predispose to a greater risk of psychiatric disorders 89 , including affective symptoms and ADHD 90 .…”

Section: Functional Enrichment In Biological Pathwaysmentioning

confidence: 99%

“…Recent epidemiological studies indicate an impact of PCE on neonatal health and neurodevelopment 18 . Specifically, PCE is associated with physical neonatal health metrics such as birth weight, birth timing and infant growth restriction 2, [19][20][21] but also traits related to childhood and adolescent neurodevelopment and brain function, for example, higher order executive function 22,23 , and psycosocial and neurobehavioural traits such as psycopathy 24 and behavioural development 25 .…”

Section: Introductionmentioning

confidence: 99%

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Prenatal cannabis exposure alters offspring DNA methylation at genes involved in neurodevelopment, across the life course

Osborne

Noble

Adams

et al. 2023

Preprint

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Prenatal cannabis exposure (PCE) is of increasing concern globally, due to the potential impact on offspring neurodevelopment, and its association with childhood and adolescent brain development and cognitive function. However, a lack of research addressing the molecular impact of PCE means that it is not known whether PCE can be considered causative for adverse child neurodevelopment, or whether it is simply correlational. To address this knowledge gap, here we present epigenome-wide association study data across multiple timepoints, examining the effect of PCE and co-exposure with tobacco using two longitudinal studies, the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Christchurch Health and Development Study (CHDS) at birth (0 y), 7 y and 15-17 y (ALSPAC), and ~27 y (CHDS). Our findings reveal genome-wide significant DNA methylation differences in offspring at 0 y, 7 y, 15-17 y and 27 y associated with PCE alone, and co-exposure with tobacco. Importantly, we identified significantly differentially methylated CpG sites within the genes LZTS2, NPSR1, NT5E, CRP2, DOCK8, COQ5 and LPAR5 that are shared between different time points throughout development in offspring. Notably, functional pathway analysis showed enrichment for differential DNA methylation in neurodevelopmental and schizophrenia pathways, and this was consistent across all timepoints in both cohorts. Given the increasing volume of epidemiological evidence that suggests a link between PCE and adverse neurodevelopmental outcomes in exposed offspring, this work highlights the need for further investigation into PCE, particularly in larger cohorts.

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Section: Functional Enrichment In Biological Pathwaysmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prenatal cannabis exposure alters offspring DNA methylation at genes involved in neurodevelopment, across the life course

Osborne

Noble

Adams

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Systematic review: the impact of maternal pre-and postnatal cannabis use on the behavioral and emotional regulation in early childhood

Reyentanz,

Gerlach,

Kuitunen-Paul

et al. 2024

Eur Child Adolesc Psychiatry

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Prenatal exposure to alcohol and tobacco has been associated with child regulatory abilities and problems, but less is known about the associations with cannabis exposure. This review seeks to address this gap primarily focusing on the effects of maternal cannabis use on the child. Thus, we investigate the association between pre- and postnatal cannabis exposure of the child and regulatory abilities and problems, as well as the underlying neurobiological mechanisms potentially mediating the associations. According to the PRISMA guidelines, a systematic literature review was performed based on a systematic literature search through Medline (PubMed), Web of Science and PsycInfo, including studies assessing children aged 0–6 years with cannabis exposure in the preconception, pre-or postnatal period (preconception, pre- and postnatal cannabis exposure [PCE]) and investigating child regulatory abilities, regulatory problems or neurobiological mechanisms. Of n = 1061 screened articles, n = 33 were finally included. Diminished regulatory abilities are more likely to be found in infants after PCE, while specific regulatory problems tend to be more frequently found after two years of age. Possible mechanisms are related to changes in methylation and expression of key genes involved in endocannabinoid, dopaminergic and opioid systems, increased cortisol reactivity and altered Secretory Immunoglobulin A levels. Furthermore, PCE has been associated with changes in brain structure and connectivity. Current findings indicate that PCE is associated with both age-dependent alterations in self-regulation and neurobiological changes in young children. However, evidence is limited due to the number of studies, small sample sizes and lack of control for maternal psychopathology. Longitudinal studies including psychometric data from mothers are needed in order to further understand the implications of PCE.Trial registration: The review is registered with PROSPERO (ID: CRD42023425115).

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Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course

Noble,

Adams,

Satsangi

et al. 2024

Mol Psychiatry

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Prenatal cannabis exposure (PCE) is of increasing concern globally, due to the potential impact on offspring neurodevelopment, and its association with childhood and adolescent brain development and cognitive function. However, there is currently a lack of research addressing the molecular impact of PCE, that may help to clarify the association between PCE and neurodevelopment. To address this knowledge gap, here we present epigenome-wide association study data across multiple time points, examining the effect of PCE and co-exposure with tobacco using two longitudinal studies, the Avon Longitudinal Study of Parents and Children (ALSPAC) and the Christchurch Health and Development Study (CHDS) at birth (0 y), 7 y and 15–17 y (ALSPAC), and ~27 y (CHDS). Our findings reveal genome-wide significant DNA methylation differences in offspring at 0 y, 7 y, 15–17 y, and 27 y associated with PCE alone, and co-exposure with tobacco. Importantly, we identified significantly differentially methylated CpG sites within the genes LZTS2, NPSR1, NT5E, CRIP2, DOCK8, COQ5, and LRP5 that are shared between different time points throughout development in offspring. Notably, functional pathway analysis showed enrichment for differential DNA methylation in neurodevelopment, neurotransmission, and neuronal structure pathways, and this was consistent across all timepoints in both cohorts. Given the increasing volume of epidemiological evidence that suggests a link between PCE and adverse neurodevelopmental outcomes in exposed offspring, this work highlights the need for further investigation into PCE, particularly in larger cohorts.

show abstract

A Review of Associations between Externalizing Behaviors and Prenatal Cannabis Exposure: Limitations & Future Directions

Cited by 3 publications

References 90 publications

Prenatal cannabis exposure alters offspring DNA methylation at genes involved in neurodevelopment, across the life course

Prenatal cannabis exposure alters offspring DNA methylation at genes involved in neurodevelopment, across the life course

Systematic review: the impact of maternal pre-and postnatal cannabis use on the behavioral and emotional regulation in early childhood

Prenatal cannabis exposure is associated with alterations in offspring DNA methylation at genes involved in neurodevelopment, across the life course

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