A review of associations between Crohn’s disease and consumption of sugars

Riordan, A. M.; Ruxton, C. H. S.; Hunter, John

doi:10.1038/sj.ejcn.1600556

Cited by 87 publications

(46 citation statements)

References 23 publications

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“…It is suggested, however, that the greater consumption of sugars in CD patients may be a result rather than a cause of the disease. Furthermore, it was recently suggested by Riordon et al, that the reported increased current sugar intake of CD patients may be a consequence of active disease (Riordan et al, 1998). In the present study, four CD patients scored a CDAI above 150, indicating active disease.…”

Section: Discussionsupporting

confidence: 59%

Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls

et al. 2000

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Objective: Malnutrition is observed frequently in patients with in¯ammatory bowel disease (IBD). Knowledge of the nutritional status in patients with recently diagnosed IBD is limited. The aim of this study was to establish a comprehensive picture of the nutritional status in recently diagnosed IBD patients. Subjects: Sixty-nine IBD patients (23 Crohn's disease (CD) and 46 with ulcerative colitis (UC)) within 6 months of diagnosis and 69 age-and sex-matched population controls were included in the study. Methods: The nutritional status was assessed by: (1) body composition (anthropometry and dual-energy X-ray absorptiometry); (2) dietary intake (dietary history); (3) biochemical indexes of nutrition; and (4) muscle strength (isokinetic dynamometer). Results: Body weight and body mass index were signi®cantly lower in UC patients compared with controls. The mean daily intake of carbohydrates was signi®cantly higher in CD patients and the intakes of protein, calcium, phosphorus, and ribo¯avin were signi®cantly lower in UC patients compared with controls, respectively. Serum concentrations of several nutrients (b-carotene, magnesium, selenium and zinc) were signi®cantly lower in UC patients compared with controls. Serum vitamin B 12 concentration was signi®cantly lower in CD patients. Muscle strength did not signi®cantly differ between IBD patients and controls.

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Section: Discussionsupporting

confidence: 59%

Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls

et al. 2000

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“…The literature data emphasize the problem of increased sugar consumption, especially saccharose, in patients with Crohn's disease (9,19,20). The question is whether it is a factor promoting manifestation of IBD, particularly Crohn's disease.…”

Section: Original Article Wiecek Et Al Disaccharidases In Ibdmentioning

confidence: 99%

“…Elemental diet also shows immunological effects by increasing the supply of food and macromolecular antigens, changing intestinal bacterial flora, inhibiting intestinal loss of lymphocytes, and decreasing synthesis of inflammatory mediators. An adequate dietary regimen leads to improved protein and energetic balance, correction of micronutrient deficiency (vitamins, trace elements), and decreased intestinal loss of nutrients (6)(7)(8)(9).…”

Section: Malabsorption Of Carbohydrates Can Bementioning

confidence: 99%

Disaccharidase activity in children with inflammatory bowel disease

Więcek

Woś²,

Radziewicz-Winnicki³

et al. 2014

Turk J Gastroenterol

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Background/Aims: The etiopathogenesis of inflammatory bowel disease (IBD) is multifactorial and not well explained. Environmental, genetic, and dietary factors play an important role. The aim of the study was the evaluation of lactase, saccharase, and maltase activity in patients with IBD. Materials and Methods: The study comprised 65 children, aged 3-18 years. During a routine endoscopy, we took biopsies from the descending part of the duodenum. In these biopsies, we determined disaccharidase activity using Dahlquist's method. Results: Decreased lactase activity in the biopsies taken from the small intestine mucosa was most frequently observed in patients with Crohn's disease (5/15-33%) and least frequently seen in children with lymphocytic colitis (in 1/10-10%). The lowest mean values of lactase activity were found in the children with Crohn's disease and ulcerative colitis (1.7-2.5 U/1 g). Decreased saccharase activity in the biopsies obtained from the small intestine mucosa was most frequently observed in patients with lymphocytic colitis (in 5/10-50%) and ulcerative colitis (9/20-45%) and least frequently seen in children with non-specific undetermined colitis (in 7/20-35%). Decreased maltase activity in the small bowel mucosa was the most frequently observed in patients with Crohn's disease (in 5/15-33%) and least frequently seen in children with ulcerative colitis (in 3/20-15%). The lowest mean values of maltase activity were found in the children with Crohn's disease (5.4 U/1 g). Conclusion: Therefore, it seems reasonable to perform diagnostic examinations aimed at lactose, saccharose, and maltose intolerance and to initiate a dietary regimen in children with IBD.

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“…The immunopathogenesis and therapy in IBD diet and disease pathophysiology has been considered, and immunologic mechanisms have been postulated to link food antigens and the development of intestinal inflammation. Some reports have suggested that consumption of refined sugar might be a risk factor for CD, but not UC [72] . Fat intake has been reported to be positively associated with UC, whereas fruit, vegetables, and fiber consumption seem to decrease the risk of IBD [73] .…”

Section: Dietary Nutrientsmentioning

confidence: 99%

Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy

Torres¹,

Rı́os

2008

WJG

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A l t h o u g h t h e a e t i o l o g y o f i n f l a m m a t o r y b o w e l disease (IBD) remains unknown, the pathogenesis is gradually being unravelled, seeming to be the result of a combination of environmental, genetic, and immunological factors in which an uncontrolled immune response within the intestinal lumen leads to inflammation in genetically predisposed individuals. Multifactorial evidence suggests that a defect of innate immune response to microbial agents is involved in IBD. This editorial outlines the immunopathogenesis of IBD and their current and future therapy. We present IBD as a result of dysregulated mucosal response in the intestinal wall facilitated by defects in epithelial barrier function and the mucosal immune system with excessive production of cytokines growth factors, adhesion molecules, and reactive oxygen metabolites, resulting in tissue injury. Established and evolving therapies are discussed in the second part of this editorial and at the end of this section we review new therapies to modulate the immune system in patients with IBD.

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A review of associations between Crohn’s disease and consumption of sugars

Cited by 87 publications

References 23 publications

Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls

Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls

Disaccharidase activity in children with inflammatory bowel disease

Current view of the immunopathogenesis in inflammatory bowel disease and its implications for therapy

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