A Review of CAR-T Therapy in Pediatric and Young Adult B-Lineage Acute Leukemia: Clinical Perspectives in Singapore

ObjectivesThis manuscript presents a bibliometric and visualization analysis of Total Body Irradiation (TBI) research, aiming to elucidate trends, gaps, and future directions in the field. This study aims to provide a comprehensive overview of the global research landscape of TBI, highlighting its key contributions, evolving trends, and potential areas for future exploration.MethodsThe data for this study were extracted from the Web of Science Core Collection (WoSCC), encompassing articles published up to May 2023. The analysis included original studies, abstracts, and review articles focusing on TBI-related research. Bibliometric indicators such as total publications (TP), total citations (TC), and citations per publication (C/P) were utilized to assess the research output and impact. Visualization tools such as VOS Viewer were employed for thematic mapping and to illustrate international collaboration networks.ResultsThe analysis revealed a substantial body of literature, with 7,315 articles published by 2,650 institutions involving, 13,979 authors. Full-length articles were predominant, highlighting their central role in the dissemination of TBI research. The authorship pattern indicated a diverse range of scholarly influences, with both established and emerging researchers contributing significantly. The USA led in global contributions, with significant international collaborations observed. Recent research trends have focused on refining TBI treatment techniques, investigating long-term patient effects, and advancing dosimetry and biomarker studies for radiation exposure assessments.ConclusionsTBI research exhibits a dynamic and multifaceted landscape, driven by global collaboration and innovation. It highlights the clinical challenges of TBI, such as its adverse effects and the need for tailored treatments in pediatric cases. Crucially, the study also acknowledges the fundamental science underpinning TBI, including its effects on inflammatory and apoptotic pathways, DNA damage, and the varied sensitivity of cells and tissues. This dual focus enhances our understanding of TBI, guiding future research toward innovative solutions and comprehensive care.

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Innovations in Pathophysiology, Diagnosis, Genomic Medicine and State-of-the-Art Treatment Approaches in Pediatric Acute Lymphoblastic Leukemia in the Twenty-First Century

AlAnazi,

AlMukhaylid,

Iqbal

2024

Common Childhood Diseases - Diagnosis, Prevention and Management [Working Title]

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Innovative advancements in the twenty-first-century technologies have revealed new genetic, immunological, and cellular biological mechanisms that contribute to understanding the biology and pathogenesis of pediatric as well as adulthood diseases. These advancements have sparked a significant revolution in the diagnosis, prognosis, and treatment of different cancers including hematological malignancies, particularly leukemia. Numerous molecular genetic assays have been developed to select optimal drugs and clinical protocols for leukemia patients. This personalized approach to treatment aims to achieve better clinical outcomes with reduced drug side effects. Genomic medicine has made basic genetic testing necessary for every clinic and hospital. This book provides an account of classical and novel developments in pediatric acute lymphoblastic leukemia (ALL) as most common childhood malignancy, that have resulted from state-of-the-art genetic, cell biological, and immunological research during the last three decades. Moreover, it also provides deep insights into the innovation in differential diagnosis, risk stratification, patient-tailored treatment, and accurate therapeutic follow-up for timely therapeutic interventions in the recent era of modern science and technology innovations of the twenty-first century that has fascinatingly improved clinical outcome of this deadly disease of the childhood.

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A Review of CAR-T Therapy in Pediatric and Young Adult B-Lineage Acute Leukemia: Clinical Perspectives in Singapore

Cited by 3 publications

References 70 publications

Paediatric Acute Lymphoblastic Leukaemia: A Narrative Review of Current Knowledge and Advancements

Paediatric Acute Lymphoblastic Leukaemia: A Narrative Review of Current Knowledge and Advancements

Global research trends in Total Body Irradiation: a bibliometric analysis

Innovations in Pathophysiology, Diagnosis, Genomic Medicine and State-of-the-Art Treatment Approaches in Pediatric Acute Lymphoblastic Leukemia in the Twenty-First Century

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