The integration of wireless antenna sensors for cyber-physical systems has become increasingly prevalent in various biosimilar applications due to the escalating need for monitoring techniques that are efficient, accurate, and reliable. The primary objective of this comprehensive investigation is to offer a scholarly examination of the present advancements, challenges, and potentialities in the realm of wireless antenna sensor technology for monitoring biosimilars. Specifically, the focus will be on the current state of the art in wireless antenna sensor design, manufacturing, and implementation along with the discussion of cyber security trends. The advantages of wireless antenna sensors, including increased sensitivity, real-time data gathering, and remote monitoring, will next be discussed in relation to their use in a variety of biosimilar applications. Furthermore, we will explore the challenges of deploying wireless antenna sensors for biosimilar monitoring, such as power consumption, signal integrity, and biocompatibility concerns. To wrap things off, there will be a discussion about where this subject is headed and why collaborative work is essential to advancing wireless antenna sensor technology and its applications in biosimilar monitoring. Providing an in-depth overview of the present landscape and potential developments, this article aims to be an asset for academics and professionals in the fields of antenna sensors, biosimilar development, wireless communication technologies, and cyber physical systems.INDEX TERMS Cyber-physical systems, wireless antenna sensors, biosimilar monitoring, real-time data acquisition.