A Review of Chronic Kidney Disease and the Immune System: A Special Form of Immunosenescence

Hsu, Hsin-Wen; Lang, Cheng-Lin; Wang, Min-Hui; Chiang, Chih-Kang; Lu, Kuo‐Cheng

doi:10.4172/2167-7182.1000144

Cited by 3 publications

(3 citation statements)

References 81 publications

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“…In our main analysis, we found no association between dialysis duration and cardiovascular events but we did find a statistically significant association between dialysis duration and hospitalization for infection with recipients on dialysis for more than 1.43 years (i.e., dialysis duration quintiles 2–5) having a significantly increased rate of post‐transplant hospitalization compared to individuals on dialysis less than 1.44 years (i.e., quintile 1). One potential reason for the increased risk of hospitalization for infection is the impact of long‐term dialysis on immune function 36,37 …”

Section: Discussionmentioning

confidence: 99%

Pre‐transplant maintenance dialysis duration and outcomes after kidney transplantation: A multicenter population‐based cohort study

Naylor

Kim

Kuwornu³

et al. 2022

Clinical Transplantation

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The association between pre‐transplant dialysis duration and post‐transplant outcomes may vary by the population and endpoints studied. We conducted a population‐based cohort study using linked healthcare databases from Ontario, Canada including kidney transplant recipients (n = 4461) from 2004 to 2014. Our primary outcome was total graft failure (i.e., death, return to dialysis, or pre‐emptive re‐transplant). Secondary outcomes included death‐censored graft failure, death with graft function, mortality, hospitalization for cardiovascular events, hospitalization for infection, and hospital readmission. We presented results by pre‐transplant dialysis duration (pre‐emptive transplant, and .01–1.43, 1.44–2.64, 2.65–4.25, 4.26–6.45, and 6.46–36.5 years, for quintiles 1–5). After adjusting for clinical characteristics, pre‐emptive transplantation was associated with a lower rate of total graft failure (adjusted hazard ratio [aHR] .68, 95% CI: .46, .99), while quintile 4 was associated with a higher rate (aHR 1.31, 95% CI: 1.01, 1.71), when compared to quintile 1. There was no significant relationship between dialysis duration and death‐censored graft failure, cardiovascular events, or hospital readmission. For death with graft function and mortality, quintiles 3–5 had a significantly higher aHR compared to quintile 1, while for infection, quintiles 2–5 had a higher aHR. Longer time on dialysis was associated with an increased rate of several adverse post‐transplant outcomes.

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Section: Discussionmentioning

confidence: 99%

Pre‐transplant maintenance dialysis duration and outcomes after kidney transplantation: A multicenter population‐based cohort study

Naylor

Kim

Kuwornu³

et al. 2022

Clinical Transplantation

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“…The disease seems to be more common in the elderly population considering chronological aging. CKD is characterized by senescence, and CKD and ESRD patients appear to be biologically older ( 93 ) due to their global malfunction status, when compared to a healthy population.…”

Section: Chronic Kidney Disease and Immunosenescencementioning

confidence: 99%

Microbiome, Immunosenescence, and Chronic Kidney Disease

et al. 2021

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The gut microbiome is known as an important predictive tool for perceiving characteristic shifts in disease states. Multiple renal diseases and pathologies seem to be associated with gut dysbiosis which directly affects host homeostasis. The gastrointestinal-kidney dialogue confers interesting information about the pathogenesis of multiple kidney diseases. Moreover, aging is followed by specific shifts in the human microbiome, and gradual elimination of physiological functions predisposes the microbiome to inflammaging, sarcopenia, and disease. Aging is characterized by a microbiota with an abundance of disease-associated pathobionts. Multiple factors such as the immune system, environment, medication, diet, and genetic endowment are involved in determining the age of the microbiome in health and disease. Our present review promotes recently acquired knowledge and is expected to inspire researchers to advance studies and investigations on the involved pathways of the gut microbiota and kidney axis.

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“…Infection has become the second most common cause of death in patients with ESRD after CVD. 10 In addition to bacterial infections, ESRD patients on MHD are also susceptible to viral infections like hepatitis B and C virus, HIV or influenza virus infection. On the other hand, there are additional difficulties in the management of ESRD patients on maintenance hemodialysis who have COVID-19.…”

Section: Covid-19 and Hemodialysismentioning

confidence: 99%

Clinical Characteristics and degree of severity of COVID-19 in Hemodialysis Patients in Armed Forces Institute of Urology.

Umar¹,

Sabir²,

Raja³

et al. 2021

Pak J Kidney Dis

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Introduction This study was conducted to evaluate the clinical characteristics and severity of COVID -19 in hemodialysis patients at from 1st March 2020 to 15th August 2020. Methodology It was a prospective and Cross Sectional Observational Study. We collected data prospectively that includes all patients on maintenance hemodialysis and reviewed clinical characteristics of those with laboratory-confirmed COVID-19 between March 1and August 15, 2020. Results 39 out of 268 dialysis dependent patients had COVID-19. Mean age of patients was 55.9yrs. Only 35.8% patients were symptomatic. 15 out of 39 were having mild disease,12 had moderate and 12 had severe disease. Females (54.5%) were found to be more affected than males(45.5%). Dry cough was the commonest symptom (53.8%) followed by fever (46.1%) and abdominal pain(18.1%). Patients with multiple comorbidities were found to have severe disease. Conclusion We concluded that patients receiving maintenance hemodialysis are susceptible to COVID-19 and that hemodialysis centers are high risk for spread of infection. Isolating patients with COVID-19 can help in preventing the spread of COVID-19.

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A Review of Chronic Kidney Disease and the Immune System: A Special Form of Immunosenescence

Cited by 3 publications

References 81 publications

Pre‐transplant maintenance dialysis duration and outcomes after kidney transplantation: A multicenter population‐based cohort study

Pre‐transplant maintenance dialysis duration and outcomes after kidney transplantation: A multicenter population‐based cohort study

Microbiome, Immunosenescence, and Chronic Kidney Disease

Clinical Characteristics and degree of severity of COVID-19 in Hemodialysis Patients in Armed Forces Institute of Urology.

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