A Review of Clinical Research Trends in the Treatment of Primary Headache Disorders with Pharmacopuncture

신, 희연; 이, 상화; 김, 하리; 김, 정화; 양, 승보; 조, 승연; 박, 정미; 고, 창남; 박, 성욱

doi:10.22246/jikm.2018.39.6.1191

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…The ground parts have been used as a medicinal, conspicuous aroma, and as condiment materials in beverages, baking, cosmetics, and the pharmaceutical industry [1]. The dried rhizomes (Cnidii Rhizoma) have been especially utilized in East-Asia countries for the treatment of female menstrual disorders and headaches through a decrease in inflammation and an improvement in blood circulation [2,3]. Many studies have also reported the rhizomes as having anti-cancer [4], analgesic [5], antibacterial [6], anticonvulsive [7], anti-inflammatory [4,5], febrifuge, hypotensive [8], sedative [9], and vasodilator [10] effects.…”

Section: Introductionmentioning

confidence: 99%

New phenylalkanoids from the rhizome of Cnidium officinalis Makino

et al. 2021

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Cnidium officinalis rhizomes were immersed in 80% MeOH. The extract was fractionated to water, n-butanol, and ethyl acetate fractions (Fr). Open column chromatography was repeatedly carried out on n-butanol and ethyl acetate Fr using silica gel, octadecyl silica gel, and Sephadex LH-20 as the stationary phase affording five phenyl alkanoids 1–5 including two new ones. The molecular structures including stereochemistry were decided based on spectroscopic interpretation of nuclear magnetic resonance, mass spectrometry, and infrared spectroscopy as well as chemical reaction. Three known compounds, coniferyl alcohol methyl ether (1), vanillin (2), and coniferyl aldehyde (3), were reported in the beginning for this plant by authors. Two new phenyl alkanoids were named, 7-methoxyeugenol and cnidiumoside.

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Section: Introductionmentioning

confidence: 99%

New phenylalkanoids from the rhizome of Cnidium officinalis Makino

et al. 2021

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“…Cnidium officinale Makino (Apiaceae) is a perennial flowering plant extensively cultivated in East Asian countries [1]. The rhizomes of C. officinale have been used traditionally in Korea, China, and Japan to treat female sexual disorders such as oligomenorrhea, hypomenorrhea, and amenorrhea by improving blood circulation, but also to relieve pain and inflammation [2,3]. Extracts of Cnidium officinale rhizome are reported to have antioxidant [4], anti-inflammatory [5,6], anticancer [5], blood circulation improvement [7], analgesic [6], anticonvulsive [8], and sedative [9] effects.…”

Section: Introductionmentioning

confidence: 99%

Three New Phthalide Glycosides from the Rhizomes of Cnidium officinale and Their Recovery Effect on Damaged Otic Hair Cells in Zebrafish

Kim

et al. 2021

Molecules

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The extract from Cnidium officinale rhizomes was shown in a prior experiment to markedly recover otic hair cells in zebrafish damaged by neomycin. The current study was brought about to identify the principal metabolite. Column chromatography using octadecyl SiO2 and SiO2 was performed to isolate the major metabolites from the active fraction. The chemical structures were resolved on the basis of spectroscopic data, including NMR, IR, MS, and circular dichroism (CD) data. The isolated phthalide glycosides were assessed for their recovery effect on damaged otic hair cells in neomycin-treated zebrafish. Three new phthalide glycosides were isolated, and their chemical structures, including stereochemical characteristics, were determined. Two glycosides (0.1 μM) showed a recovery effect (p < 0.01) on otic hair cells in zebrafish affected by neomycin ototoxicity. Repeated column chromatography led to the isolation of three new phthalide glycosides, named ligusticosides C (1), D (2), and E (3). Ligusticoside C and ligusticoside E recovered damaged otic hair cells in zebrafish.

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A Review of Domestic and International Clinical Research Trends on Pharmacopuncture Treatment for Fractures

Chun

2023

kjopp

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A Review of Clinical Research Trends in the Treatment of Primary Headache Disorders with Pharmacopuncture

Cited by 4 publications

References 30 publications

New phenylalkanoids from the rhizome of Cnidium officinalis Makino

New phenylalkanoids from the rhizome of Cnidium officinalis Makino

Three New Phthalide Glycosides from the Rhizomes of Cnidium officinale and Their Recovery Effect on Damaged Otic Hair Cells in Zebrafish

A Review of Domestic and International Clinical Research Trends on Pharmacopuncture Treatment for Fractures

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