A Review of Current and Future Treatment Strategies for Malignant Astrocytomas in Adults

Abstract

Several rational new approaches are now entering clinical trials (Table 2). In the light of limited survival after standard treatment it is recommended that patients should be offered participation in such trials.

Prognostic Factors in Glioblastoma Multiforme 10 Years Experience of a Single Institution

“…The present study revealed age, neurological performance scale, addition of radiotherapy and extend of resection as prognostic factors at multivariate analysis, which is in agreement with other publications on prognostic factors [2,4,16,17,27]. In this study a total or nearly total resection according to the statement of the neurosurgeon was of prognostic value.…”

“…Considering the limited survival with standard treatments it is recommended to enter glioblastoma patients in trials investigating new alternative strategies, based on recent advances in our knowledge about the biology of malignant gliomas [16]. At fundamental level we are currently investigating the cellular kinetics of malignant gliomas in relation to their genetic aberrations in glioma cell cultures and human glioblastoma multicellular spheroids, in order to individualize treatment in the future.…”

“…These innovations can have an influence on treatment results and prognostic factors. Generally accepted favorable prognostic factors for glioblastoma multiforme are low age, good performance, normal mental status, totally resected tumors and dexamethason independence [2,4,16]. The purpose of this retrospective analysis of all glioblastoma multiforme patients presented at an academic radiotherapy department, is to provide an update of prognostic factors over the last 10 years including the results of modern radiation schemes.…”

Patterns of Failure Following CT-Based 3-D Irradiation for Malignant Glioma

“…The late side effects of therapeutic irradiation are significantly higher in patients who received a whole brain irradiation [1,4,5,7,19]. The improvements in tumor localization via CT, MRI and SPECT and better treatment planning made precise limited volume irradiation feasible in the last decade [16,22].…”

Autorenschaft wissenschaftlicher Veröffentlichungen Analyse der Zeitschrift “Strahlentherapie und Onkologie”

“…In den untersuchten Jahrgängen gab es 14 Publikationen mit nur einem einzigen Autor [21,36,38,66,69,80,86,88,100,111,117,135,141,158]. Insgesamt 20 Publikationen hatten zwei Autoren [8,9,28,37,50,65,78,103,109,114,116,123,124,148,149,150,151,157,163,164], 21 Publikationen drei Autoren [6,20,35,40,41,42,43,52,70,73,74,75,112,122,126,127,132,…”