A Review of Dietary <i>Ziziphus jujuba</i> Fruit (Jujube): Developing Health Food Supplements for Brain Protection

Chen, Jianping; Xiao-yan, Liu; Li, Zhonggui; Qi, Airong; Yao, Ping; Zhou, Zhong‐Yu; Dong, Tina Ting Xia; Tsim, Karl Wah Keung

doi:10.1155/2017/3019568

Cited by 103 publications

(79 citation statements)

References 58 publications

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“…Ennab flowers are small and yellow-green in color, bearing sweet brown fruits when ripe that are often consumed as snacks by the locals [ 39 , 40 ]. It has been reported that traditional medicines of the Chinese and Korean uses the Ennab fruit and its seeds to alleviate stress [ 41 , 42 ]. Furthermore, Ennab fruits have been reported to have antifungal, antibacterial, antiulcer, and anti-inflammatory activities [ 43 , 44 , 45 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

et al. 2018

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(1) Background: There is a growing need for the development of new methods for the synthesis of nanoparticles. The interest in such particles has raised concerns about the environmental safety of their production methods; (2) Objectives: The current methods of nanoparticle production are often expensive and employ chemicals that are potentially harmful to the environment, which calls for the development of “greener” protocols. Herein we describe the synthesis of gold nanoparticles (AuNPs) using plant extracts, which offers an alternative, efficient, inexpensive, and environmentally friendly method to produce well-defined geometries of nanoparticles; (3) Methods: The phytochemicals present in the aqueous leaf extract acted as an effective reducing agent. The generated AuNPs were characterized by Transmission electron microscopy (TEM), Scanning electron microscope (SEM), and Atomic Force microscopy (AFM), X-ray diffraction (XRD), UV-visible spectroscopy, energy dispersive X-ray (EDX), and thermogravimetric analyses (TGA); (4) Results and Conclusions: The prepared nanoparticles were found to be biocompatible and exhibited no antimicrobial or antifungal effect, deeming the particles safe for various applications in nanomedicine. TGA analysis revealed that biomolecules, which were present in the plant extract, capped the nanoparticles and acted as stabilizing agents.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

et al. 2018

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“…In Chinese traditional medicine, multiple functions were described for dates, such as appetizing and invigorating the spleen, removing exhaustion and supplementing stamina, quieting heart and nourishing blood, improving appearance, and delaying senility, etc. Mounting evidences from modern pharmaceutical studies also indicates health bene ts of dates, including the increase of intracellular cAMP, prevention of allergic reactions, inhibition of abnormal nerve conduction, protection of liver function, decrease of the sclerosis of vascular walls, modi cation of blood pressure, improvement of muscle power, induction of sedative-hypnotic effects, blockade of genetic mutation, alleviation of lipid per oxidation, and delay of tumor genesis [9,10].…”

Section: Discussionmentioning

confidence: 99%

Blind Dates - Potential Killers: Jujube Kernel Caused Enterobrosis Need to be Differentiated with Acute Appendicitis – A Chinese Single Center Case Series Study

Bao

Zhang

Liu³

et al. 2020

Preprint

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Background: Accidentally swallowed date kernels are high risk factors for enterobrosis. Most patients showed no obvious symptoms at the beginning but later developed lower abdominal pain, which should be differentiated with acute appendicitis, especially in elder patients without a clear medical history. This study investigated the clinical features, diagnosis and treatment of enterobrosis caused by accidentally swallowed kernel of Chinese date in adults. Methods: A retrospective analysis was performed on 14 cases of adult patients suffered from date kernel - induced enterobrosis during June 2016 to June 2019. All these patients received treatment in the first hospital of China medical university. Results: Eleven female and three male patients were diagnosed, and they were mainly in the middle to elderly age, with 12/14 patients (86%) above 50 years old. The main clinical manifestations were abdominal pain, with onset times from seven hours to four days, and all patients visited the emergency department. Physical signs of local or diffuse peritonitis were presented as guarding tenderness, rebounding, and increased rigidity. Through full-abdominal enhanced CT examination, high density linear objects were identified at the terminal or distal ileum segments in 11/14 (78%) patients. During emergent laparotomy, enterobrosis were found in all patients. Secondary perforations were also detected in 6/14 (42%) patients on the opposing side of the first puncturing sites. The fusiform kernels with two sharp tips were extracted by minimal enterotomies in 13 patients. In one patient with colonic perforation, sigmoid colostomy was performed. All patients were cured and 93% of them were discharged within two weeks. Conclusions: Full-abdominal enhanced CT examination is of great diagnostic value for the intestinal perforation caused by date kernels, and patients can benefit from early surgical treatment after definite diagnosis. Thorough exploration should be performed to detect whether a second perforation was formed on the contrary site of first piercing site. Caution should be taken to void “blind dates” ingestion, and special tools such as seeders and slicers are recommended to removal kernels in advance, thus prevent the potential killing threats of enterobrosis.

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“…As herbal medicine, one of the main functions of jujube is to relax the brain by calming down the mind and improving sleep quality. Jujube is known to possess neuroprotective activities, including protecting neuronal cells against neurotoxin stress, stimulating neuronal differentiation, increasing expression of neurotrophic factors, and promoting memory and learning [ 66 ]. A study showed that the Zizyphus jujube fruit exerts neurobiological effects, especially antioxidant and anticholinesterase activities [ 67 ].…”

Section: Neuropeptides From Plant Sourcesmentioning

confidence: 99%

Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

Prasasty

Radifar²,

Istyastono

2018

Molecules

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Acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (AChE) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of Alzheimer’s disease (AD). Natural peptides have received considerable attention as biologically important substances as a source of AChE inhibitors. These natural peptides have high potential pharmaceutical and medicinal values due to their bioactivities as neuroprotective and neurodegenerative treatment activities. These peptides have attracted great interest in the pharmaceutical industries, in order to design potential peptides for use in the prophylactic and therapy purposes. Some natural peptides and their derivatives have high commercial values and have succeeded in reaching the pharmaceutical market. A large number of peptides are already in preclinical and clinical pipelines for treatment of various diseases. This review highlights the recent researches on the various natural peptides and future prospects for AD management.

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A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection

Cited by 103 publications

References 58 publications

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

Synthesis of Gold Nanoparticles Using Leaf Extract of Ziziphus zizyphus and their Antimicrobial Activity

Blind Dates - Potential Killers: Jujube Kernel Caused Enterobrosis Need to be Differentiated with Acute Appendicitis – A Chinese Single Center Case Series Study

Natural Peptides in Drug Discovery Targeting Acetylcholinesterase

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