A Review of Different Approaches for Improving Curcumin Bioavailability

Joshi, Saurabh D.; Chavan, Rohankumar Rajaram; Jadhav, Asha S.; Thorat, Vishal H.; Gaikwad, Kalyani V.

doi:10.22270/jddt.v13i12.6267

Cited by 2 publications

(1 citation statement)

References 41 publications

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“…Since Cu and R are known for their rapid metabolization when administered orally [90,91], in future research endeavors, it is crucial to explore the pharmacokinetics of Cu and R, with a particular emphasis on improving their solubility and bioavailability. Recent studies reported promising results when nanotechnology was used for developing new Cu and R delivery formulas [92][93][94].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats with Periodontal Disease

Scrobota,

Tig,

Marcu

et al. 2024

JPM

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Background: The association of periodontal disease and diabetes is a subject of intense research in terms of etiopathology and treatment options. This research aimed to evaluate the modulation of the local inflammatory status by two natural extracts, curcumin (Cu) and rutin (R), in an experimentally induced diabetes and periodontal disease in Wistar rats. Methods: Fifty Wistar albino rats were randomly assigned to five groups: Control (C), Diabetes-associated Periodontal Disease (DP), Diabetes-associated Periodontal Disease treated with Curcumin (DPCu), Diabetes-associated Periodontal Disease treated with Rutin (DPR), and Diabetes-associated Periodontal Disease treated with both Curcumin and Rutin (DPCuR). Gingival samples were collected from all rats, and immunohistochemical markers CD3, CD20, and CD34 were evaluated to assess the local inflammatory infiltrate. Descriptive statistics were applied (SPSS24 Software, Armonk, NY, USA). Results: Rutin, alone or combined with Curcumin, reduced CD3-positive cell levels. Curcumin demonstrated superior efficacy in reducing CD20-positive cells. The combination of Curcumin and Rutin had the most important impact on both markers. Curcumin notably increased immature CD34-positive cell levels. Conclusions: Curcumin and Rutin, either alone or together, hold potential for reducing local inflammation in diabetes-induced periodontal disease in Wistar rats.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats with Periodontal Disease

Scrobota,

Tig,

Marcu

et al. 2024

JPM

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Polyvinylpyrrolidone‐functionalized graphene oxide as a nanocarrier for dual‐drug delivery of quercetin and curcumin against HeLa cancer cells

Rana,

Matiyani,

Negi

et al. 2024

Vinyl Additive Technology

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This study is to develop a nanocarrier based on polyvinylpyrrolidone (PVP)‐functionalized graphene oxide (GO–PVP), loaded with both curcumin (CUR) and quercetin (QSR), and then its performance compared with nanocarriers carrying the drugs separately. The study also aimed to investigate the cytotoxic effects of these nanocarriers on HeLa cancer cells. To achieve this, GO was synthesized using a modified version of Hummer's method and subsequently functionalized with PVP. Drug loading onto the GO and GO–PVP nanocarriers was achieved through hydrophobic interactions. Furthermore, the ability of the nanocarriers to accommodate a single drug or a combination of drugs was examined. In our study, combined system shows higher drug loading, that is, 28.1% of QSR and 24.34% of CUR onto GO–PVP–QSR–CUR nanocarrier in comparison to single drug nanocarrier systems GO–PVP–QSR and GO–PVP–CUR which loaded 22.5% of QSR and 18.73% of CUR, respectively. Notably, the synthesized nanocarrier exhibited a pH‐sensitive drug release pattern. These results collectively suggest that GO–PVP–CUR–QSR displayed significantly higher cytotoxicity against HeLa cancer cells compared to both single‐drug nanocarrier systems at the specified concentrations. In addition, future pre‐clinical and clinical studies to evaluate the safety and efficacy of GO–PVP–CUR–QSR for cancer treatment are strongly recommended.Highlights Developed nanocarrier based on polyvinylpyrrolidone functionalized GO (GO–PVP). The GO–PVP nanocarrier was loaded with both curcumin (CUR) and quercetin (QSR). GO–PVP displays a higher loading capacity for both QSR and CUR compared to GO. QSR‐ and CUR‐loaded GO–PVP nanocarriers exhibited higher cytotoxic effects.

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A Review of Different Approaches for Improving Curcumin Bioavailability

Cited by 2 publications

References 41 publications

Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats with Periodontal Disease

Evaluation of Immunohistochemical Biomarkers in Diabetic Wistar Rats with Periodontal Disease

Polyvinylpyrrolidone‐functionalized graphene oxide as a nanocarrier for dual‐drug delivery of quercetin and curcumin against HeLa cancer cells

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