A Review of Effects of Spinal Cord Stimulation on Spectral Features in Resting-State Electroencephalography

Witjes, Bart; Ottenheym, Lucas A.; Huygen, Frank; Vos, Cecile C de

doi:10.1016/j.neurom.2022.04.036

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…In the eyes-closed condition, this was an increase in alpha power accompanied by a decrease in theta power. This result is consistent with the previously assessed resting-state spectral characteristics during the application of SCS (Witjes et al, 2023), where several studies reported increase of alpha power. In addition to the possible effect of the medication, differences in the alpha-power patterns in patients P01 and P03, could have been related to stimulation type (PNS versus SCS) and the specifics of stimulation patterns.…”

Section: ) Participant P03 B)supporting

confidence: 92%

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper limb amputees

Kleeva,

Soghoyan,

Biktimirov

et al. 2024

Cerebral Cortex

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Phantom limb pain (PLP) is a distressing and persistent sensation that occurs after the amputation of a limb. While medication-based treatments have limitations and adverse effects, neurostimulation is a promising alternative approach whose mechanism of action needs research, including electroencephalographic (EEG) recordings for the assessment of cortical manifestation of PLP relieving effects. Here we collected and analyzed high-density EEG data in 3 patients (P01, P02, and P03). Peripheral nerve stimulation suppressed PLP in P01 but was ineffective in P02. In contrast, transcutaneous electrical nerve stimulation was effective in P02. In P03, spinal cord stimulation was used to suppress PLP. Changes in EEG oscillatory components were analyzed using spectral analysis and Petrosian fractal dimension. With these methods, changes in EEG spatio-spectral components were found in the theta, alpha, and beta bands in all patients, with these effects being specific to each individual. The changes in the EEG patterns were found for both the periods when PLP level was stationary and the periods when PLP was gradually changing after neurostimulation was turned on or off. Overall, our findings align with the proposed roles of brain rhythms in thalamocortical dysrhythmia or disruption of cortical excitation and inhibition which has been linked to neuropathic pain. The individual differences in the observed effects could be related to the specifics of each patient’s treatment and the unique spectral characteristics in each of them. These findings pave the way to the closed-loop systems for PLP management where neurostimulation parameters are adjusted based on EEG-derived markers.

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Section: ) Participant P03 B)supporting

confidence: 92%

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper limb amputees

Kleeva,

Soghoyan,

Biktimirov

et al. 2024

Cerebral Cortex

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“…Based on neurophysiological measures, SCS largely inhibits non-nociceptive somatosensory processing (decrease in somatosensory evoked potential amplitudes) [56]. Functional neuroimaging revealed a modulation of the thalamocortical pathways [57] and modulation of the descending nociceptive inhibitory pathways [58]. Quantitative sensory testing procedures denoted a decrease in sensory hypersensitivity due to SCS [56].…”

Section: Potential Points Of Improvements For a Holistic Approachmentioning

confidence: 99%

From pain intensity to a holistic composite measure for spinal cord stimulation outcomes

Goudman

Pilitsis

Russo

et al. 2023

British Journal of Anaesthesia

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“…Specifically, alpha rhythmic oscillatory activity was enhanced under activation of electoral nerve stimulation in patient with herpetic‐related pain 20 . Likewise, emerging data have indicated a potential role of electroencephalography (EEG) in comparison of different neuromodulation status during SCS treatment, such as tonic and burst stimulation strategy 25–27 . In addition, cortical oscillation is altered in association with pain perception 28,29 .…”

Section: Introductionmentioning

confidence: 99%

“… 20 Likewise, emerging data have indicated a potential role of electroencephalography (EEG) in comparison of different neuromodulation status during SCS treatment, such as tonic and burst stimulation strategy. 25 , 26 , 27 In addition, cortical oscillation is altered in association with pain perception. 28 , 29 However, the cortical signature of SCS therapeutic responder remains less unknown.…”

Section: Introductionmentioning

confidence: 99%

Correlation between spinal cord stimulation analgesia and cortical dynamics in pain management

Chen,

Zhang,

Han

et al. 2023

Ann Clin Transl Neurol

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AimSpinal cord stimulation (SCS) is an effective method to treat neuropathic pain. It is necessary to identify the responders of SCS analgesia before implantation. The aim of this study is to investigate the relationship between the cortical dynamics and SCS analgesia responders in pain management.MethodsResting‐state EEG recording was performed in patients who underwent short‐term implantation of spinal cord stimulation for pain therapy. We then did spectral analysis to capture the pattern of cortical oscillation between neuromodulation therapy analgesia responders and nonresponders.ResultsAbout 58.3% (14 out of 24) of participants were considered as analgesia responders, with average visual analogue scores reduction of 4.8 ± 1.0 after surgery, and 2.1 ± 0.7 for the nonresponder subgroup, respectively. The alpha oscillation was significantly enhanced in responder cohort compared with nonresponders. We also observed an increasing spectral power of gamma band in responders. Furthermore, the attenuation of pain severity was significantly correlated with the global alpha oscillation activity (r = 0.60, P = 0.002). Likely, positive and significant correlation was found between the pain relief and gamma activity (r = 0.58, P = 0.003).ConclusionsDistinct pattern of neural oscillation is associated with the analgesic effect of spinal cord stimulation in pain management, enhancement of cortical alpha and gamma oscillation may be a predictor of analgesia responders.

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A Review of Effects of Spinal Cord Stimulation on Spectral Features in Resting-State Electroencephalography

Cited by 8 publications

References 22 publications

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper limb amputees

Modulations in high-density EEG during the suppression of phantom-limb pain with neurostimulation in upper limb amputees

From pain intensity to a holistic composite measure for spinal cord stimulation outcomes

Correlation between spinal cord stimulation analgesia and cortical dynamics in pain management

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