A review of emerging PFAS contaminants: sources, fate, health risks, and a comprehensive assortment of recent sorbents for PFAS treatment by evaluating their mechanism

Teymourian, Targol; Teymoorian, Termeh; Kowsari, Elaheh; Ramakrishna, Seeram

doi:10.1007/s11164-021-04603-7

Cited by 47 publications

(26 citation statements)

References 208 publications

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“…Due to their global presence in various environmental matrices, biotas, and human populations, persistence, bioaccumulation potential, and possible adverse effects on living organisms, PFASs have drawn increasing attention as emerging pollutants in recent years (Giesy and Kannan, 2001;Silva et al, 2020;Zhao et al, 2022). According to numerous worldwide studies, in both rural and urban sites, a significant concentration of PFASs has been identified, even at great distances from the main possible sources (Teymourian et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Wang

et al. 2023

Front. Environ. Sci.

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Rapid industrial development and extensive use of chemicals have resulted in elevated concentrations of emerging contaminants worldwide, posing a substantial threat to the ecological environment and human health. Per- and polyfluoroalkyl substances (PFASs) have been recognized as emerging pollutants that are widely distributed and accumulated in the environment and they have drawn the attention of scholars for several decades. The variety, long-term use, and long-distance transmission of PFASs have resulted in the ubiquitous contamination of global ecosystems, especially in aquatic environments. Ever since perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were added to the Stockholm Convention on Persistent Organic Pollutants (POPs), they have become the most typical, eye-catching, and frequently investigated PFASs. Owing to the high stability and bioaccumulation of PFASs, as well as the adverse impact on the endocrine, immune, and nervous systems, investigating their contamination levels, risk of transfer along the food chain, and ecotoxicity should be prioritized. In addition to the important evolutionary significance as primitive vertebrates and the main consumers of aquatic environment, fishes generally exist in various aquatic food chains from the bottom to the top and occupy a critical position in terms of aquatic ecology protection; while amphibians, as the key link from aquatic to terrestrial organisms, are highly sensitive to different environmental pollutants. This review is a comprehensive summary of the toxic effects and toxicity-related factors of PFASs on aquatic vertebrates, mainly Pisces and Amphilla organisms, the characteristics of different aquatic vertebrates in toxicity investigations, and the evaluation of the feasibility of PFASs substitute applications.

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Section: Introductionmentioning

confidence: 99%

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Wang

et al. 2023

Front. Environ. Sci.

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“…Per- and polyfluoroalkyl substances (PFAS) [previously called perfluorochemicals (PFCs)] are a group of thousands of man-made chemicals that are now ubiquitously found in the environment and in living organisms. − PFAS have been manufactured for over 70 years due to their useful characteristics that include the ability to repel dirt and water, act as a surfactant, and resist high temperatures . Products containing PFAS include carpets, furniture, corrosion resistant pipes, nonstick cookware, food packaging, firefighting foam, and microwaveable food containers. , PFAS have been identified as persistent organic pollutants (POPs) or “forever chemicals” and continue to be found in the environment and animals across the globe, even in the Arctic and Antarctic regions, due to the decades of large-scale manufacturing and uncontrolled pollution in the environment. − …”

Section: Introductionmentioning

confidence: 99%

“…3 Products containing PFAS include carpets, furniture, corrosion resistant pipes, nonstick cookware, food packaging, firefighting foam, and microwaveable food containers. 2,4 PFAS have been identified as persistent organic pollutants (POPs) or "forever chemicals" and continue to be found in the environment and animals across the globe, even in the Arctic and Antarctic regions, due to the decades of largescale manufacturing and uncontrolled pollution in the environment. 5−13 1.2.…”

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confidence: 99%

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes

Brown-Leung

Cannon

2022

Chem. Res. Toxicol.

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Per- and polyfluoroalkyl substances (PFAS) are a group of persistent environmental pollutants that are ubiquitously found in the environment and virtually in all living organisms, including humans. PFAS cross the blood–brain barrier and accumulate in the brain. Thus, PFAS are a likely risk for neurotoxicity. Studies that measured PFAS levels in the brains of humans, polar bears, and rats have demonstrated that some areas of the brain accumulate greater amounts of PFAS. Moreover, in humans, there is evidence that PFAS exposure is associated with attention-deficit/hyperactivity disorder (ADHD) in children and an increased cause of death from Parkinson’s disease and Alzheimer’s disease in elderly populations. Given possible links to neurological disease, critical analyses of possible mechanisms of neurotoxic action are necessary to advance the field. This paper critically reviews studies that investigated potential mechanistic causes for neurotoxicity including (1) a change in neurotransmitter levels, (2) dysfunction of synaptic calcium homeostasis, and (3) alteration of synaptic and neuronal protein expression and function. We found growing evidence that PFAS exposure causes neurotoxicity through the disruption of neurotransmission, particularly the dopamine and glutamate systems, which are implicated in age-related psychiatric illnesses and neurodegenerative diseases. Evaluated research has shown there are highly reproduced increased glutamate levels in the hippocampus and catecholamine levels in the hypothalamus and decreased dopamine in the whole brain after PFAS exposure. There are significant gaps in the literature relative to the assessment of the nigrostriatal system (striatum and ventral midbrain) among other regions associated with PFAS-associated neurologic dysfunction observed in humans. In conclusion, evidence suggests that PFAS may be neurotoxic and associated with chronic and age-related psychiatric illnesses and neurodegenerative diseases. Thus, it is imperative that future mechanistic studies assess the impact of PFAS and PFAS mixtures on the mechanism of neurotransmission and the consequential functional effects.

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“…Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are contaminants commonly studied not only due to their long-term persistence, long-distance transportability, and common occurrence in various environmental matrices, biotas, and human populations, but also for their possible disruptive effects on the immune, metabolic and endocrine systems of living organisms [ 7 , 8 , 9 , 10 ]. In 2009, PFOS and related compounds were listed in the Stockholm Convention on Persistent Organic Pollutants (POPs) (Annex B), an international environmental treaty, signed in 2001 and effective from May 2004, aimed at eliminating or restricting the production and use of POPs.…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Per- and Polyfluoroalkyl Substances to Aquatic Invertebrates, Planktons, and Microorganisms

Wang

et al. 2022

IJERPH

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Per- and polyfluoroalkyl substances (PFASs), recognized worldwide as emerging pollutants, may pose a substantial threat to human health and our environment due to their stability, high concentrations, wide distribution, and easy accumulation. Ever since perfluorooctane sulfonate and perfluorooctanoic acid were recognized by the Stockholm Convention on Persistent Organic Pollutants, the public has become increasingly concerned about potential contamination and the environmental risks associated with PFASs. Ubiquitous PFAS contamination of drinking water, groundwater, surface water, and sediment has been detected, especially in areas with rapid industrial and economic development. Its accumulation in living organisms and foods has accentuated the importance of investigations into aquatic organisms at the bottom of the food chain, as the stability and integrity of the food web as well as the population quantity and structure of the aquatic ecosystem may be affected. This review provides a comprehensive summary of the toxic and toxicity-related effects of PFASs on aquatic plankton, aquatic invertebrates and microorganisms, the characteristics of different target aquatic organisms in toxicity investigations, and a feasibility evaluation of PFAS substitutes to provide valuable suggestions for further utilization and regulation of PFASs and their substitutes.

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A review of emerging PFAS contaminants: sources, fate, health risks, and a comprehensive assortment of recent sorbents for PFAS treatment by evaluating their mechanism

Cited by 47 publications

References 208 publications

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Toxicity of per- and polyfluoroalkyl substances to aquatic vertebrates

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes

Toxicity of Per- and Polyfluoroalkyl Substances to Aquatic Invertebrates, Planktons, and Microorganisms

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