A review of fertility preservation in patients with breast cancer

Ulrich, Nicole; Raja, Nicholas; Moravek, Molly B.

doi:10.1016/j.bpobgyn.2022.01.004

Cited by 15 publications

(8 citation statements)

References 40 publications

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“…In this study, data analysis implicates physicians' lack of knowledge about cancer-related fertility preservation. Health providers should be updated and prepared to discuss fertility preservation options with their female patients facing a new cancer diagnosis and/or to refer them properly as soon as possible [22,25,34]. 'The level of knowledge of fertility preservation by oncology care providers has a signi cant impact on patient education and the subsequent choices they make' [25].…”

Section: Discussionmentioning

confidence: 99%

“…Financial issues must be involved in shared decision making in the context of onco-fertility [22]. Patients with cancer should be made aware of the available nancial assistance programs to become more exible in addressing 'this complex and heterogeneous landscape' [22] 'during an uncertain and challenging time in their lives' [34]. Notwithstanding, there are countries where these services are totally or partly subsidized.…”

Section: Discussionmentioning

confidence: 99%

“…The 'cost and access to care remain critical barriers to fertility preservation services' [34]. Tomilová and Frühaufová argue that 'lack of information for both patients and, unfortunately, professionals' and 'the high cost of treatment' are critical barriers to fertility preservation services [9].…”

Section: Discussionmentioning

confidence: 99%

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Perceptions and experiences of fertility preservation in Greek female cancer patients

Taniskidou

Voultsos

Tarlatzis

et al. 2023

Preprint

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Background As advances in oncology have led to remarkable and steady improvements in the survival rates of cancer patients and anticancer treatment can cause premature ovarian failure in women, fertility preservation has become a global public health concern and an integral part of the care for women diagnosed with cancer during reproductive age. However, for various reasons, fertility preservation remains underutilized for cancer patients. There are substantial gaps in our knowledge about women’s experience and perceptions on the issue. This study aims to contribute to bridging that gap. Methods This prospective qualitative study was conducted from March 2018 to February 2023. A combination of purposive and snowball sampling was used. Data were collected by semi-structured interviews with nineteen reproductive-age women with a recent cancer diagnosis. Data were classified and analyzed by a thematic analysis approach. Results A variety of distinct themes and subthemes emerged from the analysis of the interview data. The cancer diagnosis emerged as a factor that considerably affects the women’s attitudes towards biological parenthood: It can further increase their (strong) previous desire or decrease their previous (weak) desire. Women with a recent cancer diagnosis did not receive adequate and multidisciplinary counselling, including clear and sufficient information. However, participants felt satisfied from the information they received because they either received the information they requested or remained in denial to get informed (i.e. because they felt overwhelmed after the cancer diagnosis). Embryo cryopreservation emerged as a less desirable fertility preservation option for women with cancer. Participants showed respect for human embryos, not always for religious reasons. Surrogacy emerged as the last resort for most participants. Religious, social or financial factors did play a secondary (if any) role in women’s decision making about fertility preservation. Finally, male partners’ opinions played a secondary role in most participants’ decision-making about fertility preservation. If embryo cryopreservation was the selected option, partners would have a say because they were involved with their genetic material. Conclusions The findings that emerged from data analysis were partly consistent with prior literature. However, we identified some interesting nuances that are of clinical importance. The results of this study may serve as a starting point for future research.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Perceptions and experiences of fertility preservation in Greek female cancer patients

Taniskidou

Voultsos

Tarlatzis

et al. 2023

Preprint

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“…Thereafter, the negative feedback at the pituitary gland causes the downregulation of GnRH receptors suppressing the downstream effects of follicle-stimulating hormone and luteinizing hormone, ultimately leading to a decreased estrogen production in premenopausal ovaries [ 104 ]. GnRH agonists cause ovarian suppression that can aid fertility preservation useful for the successive fertility treatments and pregnancies in women with a previous diagnosis of BC [ 105 ]. The most common GnRH agonists are goserelin, triptorelin, buserelin, and leuprolide [ 106 , 107 ], used only in premenopausal women with BC.…”

Section: Breast Cancer Therapiesmentioning

confidence: 99%

Targeting Breast Cancer: An Overlook on Current Strategies

Iacopetta

Ceramella

Baldino

et al. 2023

IJMS

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Breast cancer (BC) is one of the most widely diagnosed cancers and a leading cause of cancer death among women worldwide. Globally, BC is the second most frequent cancer and first most frequent gynecological one, affecting women with a relatively low case-mortality rate. Surgery, radiotherapy, and chemotherapy are the main treatments for BC, even though the latter are often not aways successful because of the common side effects and the damage caused to healthy tissues and organs. Aggressive and metastatic BCs are difficult to treat, thus new studies are needed in order to find new therapies and strategies for managing these diseases. In this review, we intend to give an overview of studies in this field, presenting the data from the literature concerning the classification of BCs and the drugs used in therapy for the treatment of BCs, along with drugs in clinical studies.

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“…Additionally, >80% of young patients with cancer express a desire for spontaneous conception ( 9 ). Fertility concerns may impact patients more than the cancer itself, because they last longer and significantly reduce the quality of life of young women with BC ( 10 ). In accordance with all guidelines, patients diagnosed with any malignancy and stage at a reproductive age must receive adequate counseling on the dangers of gonadotoxicity caused by anticancer treatment at the time of diagnosis ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Incidence and influencing factors of fertility concerns in breast cancer in young women: a systematic review and meta-analysis

Chen,

Shen,

Jiang

et al. 2023

Front. Oncol.

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ObjectiveThis systematic review and meta-analysis aimed to evaluate the prevalence and influencing factors of fertility concerns in breast cancer in young women.MethodsA literature search on PubMed, Embase, Web of Science, and Cochrane Library databases was conducted up to February 2023 and was analyzed (Revman 5.4 software) in this study. The papers were chosen based on inclusion standards, and two researchers independently extracted the data. The included studies’ quality was evaluated using criteria set out by the Agency for Healthcare Research and Quality. To identify significant variations among the risk factors, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were utilized.ResultsA total of 7 studies that included 1579 breast cancer in young women were enrolled in the study. The results showed that for breast cancer in young women, the incidence of fertility concerns 53%(95%CI [0.45,0.58]). The results showed that education (2.65, 95% CI 1.65–5.63), full-time work (0.12, 95% CI 1.03–1.93), fertility intentions (7.84, 95% CI 1.50–37.4), depression level (1.25, 95% CI 1.03–1.5), and endocrine therapy (1.32, 95% CI 1.08–1.62) were risk factors for fertility concerns in young women with BC. Having a partner (0.41, 95% CI 0.33–0.5), ≥1 child (0.3, 95% CI 0.22–0.4) were identified as protective factors against fertility concerns in young women with BC.ConclusionsThe incidence of fertility concerns in breast cancer in young women is at a moderately high level. We should pay more attention to the risk factors of fertility concerns to help breast cancer in young women cope with their fertility concerns and promote their psychological well-being.

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A review of fertility preservation in patients with breast cancer

Cited by 15 publications

References 40 publications

Perceptions and experiences of fertility preservation in Greek female cancer patients

Perceptions and experiences of fertility preservation in Greek female cancer patients

Targeting Breast Cancer: An Overlook on Current Strategies

Incidence and influencing factors of fertility concerns in breast cancer in young women: a systematic review and meta-analysis

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