A Review of Glycyrrhiza glabra (Licorice) Effects on Metabolic Syndrome

Jafari, Fatemeh; Jafari, Mohsen A.; Moghadam, Ali Tafazoli; Emami, Seyed Ahmad; Jamialahmadi, Tannaz; Mohammadpour, Amir Hooshang; Sahebkar, Amirhossein

doi:10.1007/978-3-030-73234-9_25

Cited by 10 publications

(9 citation statements)

References 62 publications

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“…Ohwi (71), Cassia obtusifolia L. (48), Nelumbo nucifera Gaertn. (48), Ganoderma Lucidum Karst (25), and Morus alba L. (22), of which C. pinnatifida is the most common one.…”

Section: The Categories and Frequencies Of Food And Medicine Homology...mentioning

confidence: 99%

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Hao,

Peng,

Guan

et al. 2024

Food &Amp; Medicine Homology

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Hyperlipidemia is a kind of lipid metabolism disease, whose pathogenesis is complex and diverse, mainly related to abnormal glucose and lipid metabolism, as well as insulin resistance and other characteristics. Because of their low toxic and side effects along with clear medicinal effects, the food and medicinal homological resources are widely used in the regulation of blood lipids in recent years. The State Administration for Market Regulation website and various databases have been searched for the use of food and medicinal homological materials in functional food products, the categories and frequency in food and medicinal homological resources, the lipid-lowering active ingredients and their mechanisms. The results showed that 53 kinds of food and medicinal homological resources were used to regulate blood lipids, of which Crataegus pinnatifida Bge., Cassia obtusifolia L., Nelumbo nucifera Gaertn., Morus alba L. and Pueraria lobata (Willd.) Ohwi were used most frequently. The main active ingredients are triterpenes and their glycosides, flavonoids, alkaloids and polysaccharides, etc., they regulated blood lipid levels and cholesterol metabolism by activating AMPK and PPARγ.

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“…Ohwi (71), Cassia obtusifolia L. (48), Nelumbo nucifera Gaertn. (48), Ganoderma Lucidum Karst (25), and Morus alba L. (22), of which C. pinnatifida is the most common one.…”

Section: The Categories and Frequencies Of Food And Medicine Homology...mentioning

confidence: 99%

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Hao,

Peng,

Guan

et al. 2024

Food &Amp; Medicine Homology

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“… 117 Treatment with different concentrations of the extract of Glycyrrhiza glabra L., the rat serum levels of cholesterol, LDL, and TG are decreased and the levels of HDL are increased. 118 Glabridin has been shown to inhibit adipogenesis in 3T3-L1 cells, and glabridin-rich extract of Glycyrrhiza glabra L. also exhibits inhibitory activity against adipogenesis by decreasing the expression of C/EBPα and PPARγ, suppressing the activity of lipoprotein lipase, glucose uptake, and PGE2, and inhibiting energy metabolism, leading to amelioration of high-fat diet (HFD)-induced hepatic steatosis 24 ( Table 1 ).…”

Section: Anti-obesitymentioning

confidence: 99%

Review on the Diverse Biological Effects of Glabridin

Zhang¹,

Wu²,

Zhong³

et al. 2023

DDDT

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Glabridin is a prenylated isoflavan from the roots of Glycyrrhiza glabra Linne and has posed great impact on the areas of drug development and medicine, due to various biological properties such as anti-inflammation, anti-oxidation, anti-tumor, anti-microorganism, bone protection, cardiovascular protection, neuroprotection, hepatoprotection, anti-obesity, and anti-diabetes. Many signaling pathways, including NF-κB, MAPK, Wnt/β-catenin, ERα/SRC-1, PI3K/AKT, and AMPK, have been implicated in the regulatory activities of glabridin. Interestingly, glabridin has been considered as an inhibitor of tyrosinase, P-glycoprotein (P-gp), and CYP2E1 and an activator of peroxisome proliferator-activated receptor γ (PPARγ), although their molecular regulating mechanisms still need further investigation. However, poor water solubility and low bioavailability have greatly limited the clinical applications of glabridin. Hopefully, several effective strategies, such as nanoemulsions, microneedles, and smartPearls formulation, have been developed for improvement.

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“…These encouraging results, coupled with the traditional reported use of G. foetida to treat hepatic and metabolic disorders [6], prompted us to carry out a more comprehensive NMR-based phytochemical screening on this plant. Indeed, besides the somewhat rare amorfrutins, present only in another couple of species of the Glycyrrhiza genus (G. acanthocarpa and G. lepidota) [7,8], additional metabolites are likely to contribute, with different mechanisms, to the positive effects of this plant on metabolic syndrome progression [9].…”

Section: Introductionmentioning

confidence: 99%

Metabolites from Aerial Parts of Glycyrrhiza foetida as Modulators of Targets Related to Metabolic Syndrome

Al-Hmadi,

Serino,

Pastore

et al. 2024

Biomolecules

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A detailed phytochemical investigation has been carried out on the aerial parts of G. foetida leading to the isolation of 29 pure compounds, mainly belonging to the amorfrutin and polyphenol classes. Among them, the new amorfrutin N (5) and exiguaflavone L (21) were isolated and their structures elucidated by means of HR-ESIMS and NMR. All the isolated compounds were investigated for modulation of mitochondrial activity and stimulation of glucose uptake via GLUT transporters, two metabolic processes involved in intracellular glucose homeostasis, which, therefore, correlate with the incidence of metabolic syndrome. These experiments revealed that amorfrutins were active on both targets, with amorfrutin M (17) and decarboxyamorfrutin A (2) emerging as mitochondrial stimulators, and amorfrutin 2 (12) as a glucose uptake promoter. However, members of the rich chalcone/flavonoid fraction also proved to contribute to this activity.

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A Review of Glycyrrhiza glabra (Licorice) Effects on Metabolic Syndrome

Cited by 10 publications

References 62 publications

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

The food and medicinal homological resources benefiting patients with hyperlipidemia: categories, functional components, and mechanisms

Review on the Diverse Biological Effects of Glabridin

Metabolites from Aerial Parts of Glycyrrhiza foetida as Modulators of Targets Related to Metabolic Syndrome

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