A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Alasmari, Abdulrahman; Al-Elaiwi, Abdulrahman M.; Athar, Tanwir; Tariq, Mohammad; Eid, Ahmed Al; Al-Asmary, Saeed M.

doi:10.1155/2014/890842

Cited by 79 publications

(57 citation statements)

References 167 publications

(175 reference statements)

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“…polyphenols, tannins composed of some gallic and mostly ellagic acid, flavonoids such as orientin, quercetin, quercitrin, isoquercetin, vitexin, rutin, hyperoside, with others, including luteolin and pro-anthocyanidins to which the main pharmacological activities of the plant [31] Also, [32] reported that A. vulgaris contain flavonoids which important for the treatment of inflammation and wound healing. Our results are agree with [33] which reported that medicinal plant A. vulgaris serve as a vital source of potentially useful new compounds for the development of effective therapy to combat liver problems.…”

Section: Data Insupporting

confidence: 93%

Effect of Lion’s Foot (Alchemilla vulgaris) on Liver and Renal Functions in Rats Induced by CCl4

El-Hadidy¹,

Refat²,

Halaby³

et al. 2018

FNS

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The present work aims to study the influence of antioxidants activity of lion's foot (Alchemilla vulgaris) leaves at different concentrations to give more protection against chronic liver disease. Results indicated that dried lion's foot leaves had rich in total polyphenolic and flavonoids content (395.65 and 183.10 mg/100g, respectively). These results were reflected to the antioxidant activity (DPPH); it's noticed that the antioxidant activity of dried lion's foot leaves was high (131.74%). The major polyphenolic components were benzoic acid (1084.63 ppm) followed by ellagic acid, catechol, and catechin (614.16, 580.54, and 566.53 ppm, respectively) then salicylic acid and protocatechuic acid (479.71 and 444.43 ppm, respectively). On the same trend, flavonoids fractions indicated the highest content in luteo-6-arabinase 8-glucose, apig. 6-rhamnase 8-glucose, acatein, narengin and luteolin (40.01; 15.04; 8.07; 6.64 and 6.42 ppm, respectively). Fifty-six male albino rats were used in biological experiments. Rats fed on basal diet for two weeks before the performance of the experiment. At the beginning, rats divided into eight main group were fed on diets for 45 days as follows: Negative control group (first group) was fed on basal diet. Forty nine rats were fed on basal diet and induced by CCl 4 , in paraffin oil (50% v/v, 2 ml/Kg) twice weeks subcutaneous injection to induce chronic damage in the liver, then divided into 7 groups numbered from group 2 to group 8. Positive control group rats fed on basal diet till final experiment (second group). Group 3 and 4 rats treated with 50 and 100 ppm ethanolic leaves extracts, respectively. Also, group 5 and 6 treated with 50 and 100 ppm aqueous leaves extracts, respectively. All extracts were fed on orally every day. While, rats in group 7 treated with 1% and 2% dried lion's foot leaves. At the end of the experimental period, serums were collected to determine liver and

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Section: Data Insupporting

confidence: 93%

Effect of Lion’s Foot (Alchemilla vulgaris) on Liver and Renal Functions in Rats Induced by CCl4

El-Hadidy¹,

Refat²,

Halaby³

et al. 2018

FNS

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“…The mechanism of hepatic injury invariably involves peroxidation of hepatocyte membrane fatty acids causing destruction of the cells and their intracellular organelles. Oxidative stress plays a pivotal role in the initiation and progression of hepatic damage following insult to a variety of hepatotoxins [60]. These toxicants damage the hepatocyte primarily by producing reactive oxygen species which form covalent bond with the lipid moiety of the hepatic cell membranes.…”

Section: Hepatoprotective Activities Of Extracts Of Plants From Africamentioning

confidence: 99%

African natural products with potential antioxidants and hepatoprotectives properties: a review

et al. 2016

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Free radicals are highly reactive molecules generated during oxidation reactions which in turn initiate chain reactions resulting to cellular damage. There is substantial evidence implicating free radicals especially reactive oxygen species (ROS) in the etiology of more than one hundred degenerative disorders in humans including, arthritis, atherosclerosis, ischemia and reperfusion injury of many tissues, gastritis, diabetics, central nervous system injury, acquired immunodeficiency syndrome (AIDS) and cancer. Scientific evidence postulates that bioactive compounds especially from natural products are capable of providing protection against free radicals. Consequently, few decades have witnessed a surfeit of research geared towards validating the antioxidant and hepatoprotective potential of the natural products. In this review, African natural products whose antioxidants activities were scientifically validated either in their crude extracts and/or derived products have been discussed. A total 1076 plants species representing 287 family, 132 isolated compounds and 7 insect/mollusk secreation were found. The plant species from the following families; Fababceae, Asteraceae, Lamiaceae, Moraceae, Euphorbiaceae, Combretaceae and Malvaceae have received more scientific attention than others. Analysis of the reports revealed that Combretum apiculatum, Telfaria occidentalis, Acalypha racemosa, Garcinia lucida were the most active plant extracts from African flora. The most active ROS-detoxifying phytochemicals were moracin T, U, S and R (84-87), oleanolic acid (54), 5,7,4′-trihydroxy-3,8,3′,5′-tetramethoxyflavone (89), 5,7,3′-trihydroxy-3,8,4′,5′-trimethoxyflavone (88), luteolin (3′,4′,5,7-tetrahydroxy flavone) (117) and genistein (4′,5,7-trihydroxyisoflavone) (116). The significant antioxidant potential demonstrated by some crude extracts and their constituent compounds render them good candidates for the development of new drugs. Although, the study of the mechanisms of actions as well as clinical validation of some of these isolated compounds is lacking. It is hoped that pertinent scientist and stakeholders will look further into some of these compounds for detailed authentification and subsequent commercialization.

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“…Medicinal herbs have been used in folk medicine for a long time and they have played a promising role in the treatment and prevention of various human diseases (AL-ASMARI et al, 2014). Despite the therapeutic advantages of medicinal plants, their potential toxicity is not recognized by the general public or by many professional groups of traditional medicine (SOETAN; AIYELAAGBE, 2009).…”

Section: Introductionmentioning

confidence: 99%

Toxicity of Jatropha curcas L. latex in Allium cepa test

Ciappina¹,

Ferreira²,

Pereira³

et al. 2017

Biosci. J.

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ABSTRACT:The latex obtained from Jatropha curcas (physic nut) is used in traditional medicine to treat a variety of disturbs, including burns, hemorrhoids, ringworm and ulcers. Phytochemical analyses have shown that J. curcas latex contains natural compounds with therapeutic potential. In this study, the toxicity, cytotoxicity and genotoxicity effects of J. curcas latex on the root cells of Allium cepa were examined. Onion seeds and bulbs were exposed to seven different concentrations of latex and then the roots were submitted to macro and microscopic analyses. Water and sodium azide were used as negative and positive controls, respectively. The analysis of root growth showed that J. curcas crude latex or 50% diluted is highly toxic. Cytogenetic results showed that the mitotic index of the onion roots submitted to latex treatment decreased significantly compared to the negative control, which suggests that the latex is cytotoxic. High incidence of chromosome aberrations in the cells treated with J. curcas latex was observed too, indicating that the latex also presents genotoxic effect. The analyses presented in this report suggest the toxic, cytotoxic and genotoxic effects of J. curcas latex. Then, the indiscriminate use of J. curcas latex in folk medicine could bring risk to human health.

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A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Cited by 79 publications

References 167 publications

Effect of Lion’s Foot (<i>Alchemilla vulgaris</i>) on Liver and Renal Functions in Rats Induced by CCl<sub>4</sub>

Effect of Lion’s Foot (<i>Alchemilla vulgaris</i>) on Liver and Renal Functions in Rats Induced by CCl<sub>4</sub>

African natural products with potential antioxidants and hepatoprotectives properties: a review

Toxicity of Jatropha curcas L. latex in Allium cepa test

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A Review of Hepatoprotective Plants Used in Saudi Traditional Medicine

Cited by 79 publications

References 167 publications

Effect of Lion’s Foot (&lt;i&gt;Alchemilla vulgaris&lt;/i&gt;) on Liver and Renal Functions in Rats Induced by CCl&lt;sub&gt;4&lt;/sub&gt;

Effect of Lion’s Foot (&lt;i&gt;Alchemilla vulgaris&lt;/i&gt;) on Liver and Renal Functions in Rats Induced by CCl&lt;sub&gt;4&lt;/sub&gt;

African natural products with potential antioxidants and hepatoprotectives properties: a review

Toxicity of Jatropha curcas L. latex in Allium cepa test

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Effect of Lion’s Foot (<i>Alchemilla vulgaris</i>) on Liver and Renal Functions in Rats Induced by CCl<sub>4</sub>

Effect of Lion’s Foot (<i>Alchemilla vulgaris</i>) on Liver and Renal Functions in Rats Induced by CCl<sub>4</sub>