A Review of Herbal Medicines for Psychiatric Disorders

Beaubrun, Gabrielle; Gray, Gregory E.

doi:10.1176/appi.ps.51.9.1130

Cited by 123 publications

(73 citation statements)

References 37 publications

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“…5 Mixture of SJW with MAOI or SSRI antidepressants, for example, can result in a serious health condition known as serotonin syndrome. 6,7 Serotonin syndrome occurs when the body is flooded with excess serotonin and can lead to muscle twitching, restlessness, breakdown of skeletal musculature, kidney failure and ultimately death. 8 Additionally, in as little as four to ten days SJW can cause some medications to metabolize too quickly thus lowering plasma concentrations and rendering treatment less effective or ineffectual.…”

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confidence: 99%

“…For example, valerian root and lemon balm may enhance the effects of other central nervous system depressants. 6,14 Lemon balm may interact with thyroid medication and/or thyroid disease.…”

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confidence: 99%

“…6 Passion flower and skullcap have so little research regarding possible drug interactions that none can be identified with certainty. However given their sedative effects, they may enhance the effects of other central nervous system depressants.…”

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confidence: 99%

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Concurrent herb-prescription medication use and health care provider disclosure among university students

McCrea¹,

Pritchard²

2011

Complementary Therapies in Medicine

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confidence: 99%

“…For example, valerian root and lemon balm may enhance the effects of other central nervous system depressants. 6,14 Lemon balm may interact with thyroid medication and/or thyroid disease.…”

mentioning

confidence: 99%

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Concurrent herb-prescription medication use and health care provider disclosure among university students

McCrea¹,

Pritchard²

2011

Complementary Therapies in Medicine

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“…Also, a single herb is used for multiple disease conditions. Herbs with potential anxiolytic activity include: 6 • Ashwagandha (withania somnifera)…”

Section: Introductionmentioning

confidence: 99%

A comparative analysis of anxiolytic activity of Arnica montana and alprazolam in rats using open field test

Jha

Bhalerao

Dhole

2018

Int J Basic Clin Pharmacol

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Background: Anxiety affects around 7.3% of the total population worldwide. Benzodiazepines are preferred anxiolytic agents and are still frequently used in spite of the side effect profile including muscle relaxation, memory disturbances, sedation, physical dependence. Arnica montana, a traditional herb is known to possess significant anxiolytic effect at the dose of 100mg/kg. In this study, Arnica montana has been compared for the first time with alprazolam, a most commonly used anxiolytic drug.Methods: Forced swim test was used to induce anxiety. Anxiolytic action of study drugs which were given orally, was evaluated using Open field test (OFT) in healthy wistar rats of either sex. Behavior of rats, locomotion and number of squares crossed was recorded. Rats were divided into four groups with eight rats in each group. Study groups were Group I Control; Group II Alprazolam 0.08mg/kg; Group III Arnica montana extract (AME) 100mg/kg; Group IV AME + Alprazolam group 100mg/kg+0.08mg/kg. Statistical analysis was done using ANOVA followed by Tukey’s test (p<0.05).Results: Increase in frequency of rearing was significant (p<0.05) in AME group and highly significant (p<0.001) in Alprazolam and combination group in comparison to control. Decrease in frequency of grooming was highly significant (p<0.001) in Alprazolam and combination group. AME also showed significant (p<0.05) decrease in grooming activity.Conclusions: Arnica montana extract showed anxiolytic activity and can be used as an add on drug after further studies and validation in the treatment of anxiety disorders.

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“…Natural anxiolytic agents feature in such research because herbs have been used to treat psychiatric disorders and generally have fewer harmful effects (Carlini, 2003). The potential clinical benefits of some herbal remedies commonly used in psychiatric practice have been addressed in earlier reviews (Fugh-Berman and Cott, 1999;Walter and Rey, 1999;Beaubrun and Gray, 2000;Lake, 2000;Linde et al, 2001a,b;Desai and Grossberg, 2003).…”

Section: Introductionmentioning

confidence: 99%

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

Lee¹,

Yoon²,

Ryu³

et al. 2009

Oriental Pharmacy and Experimental Medicine

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SUMMARYThe purpose of this study was to characterize the putative anxiolytic-like effects of the 70% ethanol extract of Portulaca oleracea (EPO) using an elevated plus maze (EPM) in mice. The EPO was orally administered at 50, 100, 200 or 400 mg/kg to ICR mice, 1 h before the behavioral evaluation in the EPM, respectively. Control mice were treated with an equal volume of 10% tween 80, and positive control mice with diazepam (1 mg/kg). Single treatments of the EPO significantly increased the percentage of time spent and arm entries into the open arms of the EPM versus controls (P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with the saline controls. In addition, the anxiolyticlike effects of the EPO were blocked by flumazenil (10 mg/kg, i.p), a GABA receptor antagonist. These results indicate that P. oleracea is an effective anxiolytic agent, and suggest that the anxiolytic-like effects of P. oleracea is mediated via the GABAergic nervous system.

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A Review of Herbal Medicines for Psychiatric Disorders

Cited by 123 publications

References 37 publications

Concurrent herb-prescription medication use and health care provider disclosure among university students

Concurrent herb-prescription medication use and health care provider disclosure among university students

A comparative analysis of anxiolytic activity of Arnica montana and alprazolam in rats using open field test

Anxiolytic-like effects of Portulaca oleraceae L. using the elevated plus-maze in mice

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