A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers

Mathias, Patricia I.; Connor, Thomas H.; B’Hymer, Clayton

doi:10.1016/j.jchromb.2017.06.028

Cited by 34 publications

(16 citation statements)

References 55 publications

(95 reference statements)

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“…While the research on surface and biological monitoring for ADs has continued with enthusiasm, demonstrated by the number of recent publications reporting improved technology for wipe [23][24][25] and urine [26][27][28] sampling, only a limited number of the studies published consider both matrices [11,13,29].…”

Section: Introductionmentioning

confidence: 99%

Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces

Dugheri¹,

Bonari²,

Pompilio³

et al. 2018

Med Pr

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Background: Cytotoxic antineoplastic drugs (ADs), widely used in treating cancer, are considered hazardous in the workplace and thus require safe handling practices. An analytical protocol for environmental and biological AD monitoring in the healthcare environment has been developed, since Europe lacks clear guidelines and regulations for cytostatic preparation and handling. Material and Methods: Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used for measuring contemporaneously 20 multi-class cytostatic compounds and urinary α-fluoro-β-alanine, whereas platinum was detected by inductively coupled plasma mass spectrometry (ICP-MS). Sampling procedures and analytical conditions were optimized and the assays were validated. Environmental AD monitoring data, collected in 2009-2017, for a total of 3749 wipe tests and 57 720 determinations, was evaluated. Results: The proportion of positive samples gradually decreased from 11.7% in 2010 to 1% in 2017, however, 2266 determinations were positive. No urine sample had detectable concentrations of any of the 4 drugs considered (0/398 samples). Conclusions: These improvements are so large that the key role played by the new, more stringent rules for preparing and administering ADs is evident. Hence, the analytical method involving multi-element determinations allows for a more thorough and complete investigation into the AD contamination of work environments.

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Section: Introductionmentioning

confidence: 99%

Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces

Dugheri¹,

Bonari²,

Pompilio³

et al. 2018

Med Pr

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“…The literature includes many reports on the analysis of individual anticancer drugs, either in a pharmaceutical formulation, environmental samples or biological sample. [7][8][9] However, this is the first report on different analytical aspects and methodologies for the quantification of anticancer drugs covering almost all biological matrices. In this review, we have discussed the techniques of analysis of anticancer drugs published in the last 10 years and organized them based on different biological matrices.…”

Section: Introduction 719 2 Modern Analytical Techniques For Bioanalymentioning

confidence: 99%

An Exploration of Advancement in Analytical Methodology for Quantification of Anticancer Drugs in Biomatrices

et al. 2019

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Significant numbers of newer anticancer drugs are regularly entering into the market worldwide to fight against different types of cancers. Analytical methodologies are being developed to quantitate those molecules in a variety of matrices during their drug development stages. Selection of biological matrices for developing bioanalytical methods is based on the mechanism of action, site of action, site of metabolism and route of excretion of the drugs or their metabolites. In this review, we have described the current scenario and advancements in bioanalytical techniques for quantification of different anticancer drugs in a variety of biomatrices with a special emphasis on sample preparation techniques. We have discussed and summarized different bioanalytical aspects for anticancer drugs, which can give direction to the researcher for choosing appropriate techniques for their quantification needs.

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“…The limit of detection (LOD) value in urine, for six of them, is from 0.0132–34 to 0.02 ng/L 35. For the others, the LOD value in urine is from 0.05 to 1 ng/L 36…”

Section: Introductionmentioning

confidence: 99%

Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross-sectional multicentre descriptive study

et al. 2019

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IntroductionAntineoplastic drugs (AD) are potentially carcinogenic and/or reprotoxic molecules. Healthcare professionals are increasingly exposed to these drugs and can be potentially contaminated by them. Internal contamination of professionals is a key concern for occupational physicians in the assessment and management of occupational risks in healthcare settings. Objectives of this study are to report AD internal contamination rate in nursing staff and to identify factors associated with internal contamination.Methods and analysisThis trial will be conducted in two French hospital centres: University Hospital of Bordeaux and IUCT-Oncopole of Toulouse. The target population is nurses practicing in one of the fifteen selected care departments where at least one of the five studied AD is handled (5-fluorouracil, cyclophosphamide, doxorubicin, ifosfamide, methotrexate). The trial will be conducted with the following steps: (1) development of analytical methods to quantify AD urine biomarkers, (2) study of the workplace and organization around AD in each care department (transport and handling, professional practices, personal and collective protection equipments available) (3) development of a self-questionnaire detailing professional activities during the day of inclusion, (4) nurses inclusion (urine samples and self-questionnaire collection), (5) urine assays, (6) data analysis.Ethics and disseminationThe study protocol has been approved by the French Advisory Committee on the Treatment of Information in Health Research (CCTIRS) and by the French Data Protection Authority (CNIL). Following the opinion of the Regional Committee for the Protection of Persons, this study is outside the scope of the provisions governing biomedical research and routine care (n°2014/87). The results will be submitted to peer-reviewed journals and reported at suitable national and international meetings.Trial registration numberNCT03137641.

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A review of high performance liquid chromatographic-mass spectrometric urinary methods for anticancer drug exposure of health care workers

Cited by 34 publications

References 55 publications

Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces

Analytical strategies for assessing occupational exposure to antineoplastic drugs in healthcare workplaces

An Exploration of Advancement in Analytical Methodology for Quantification of Anticancer Drugs in Biomatrices

Study protocol for the assessment of nurses internal contamination by antineoplastic drugs in hospital centres: a cross-sectional multicentre descriptive study

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