A review of immunologic diseases of the dog

Pedersen, Niels C

doi:10.1016/s0165-2427(99)00059-8

Cited by 58 publications

(70 citation statements)

References 289 publications

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“…Considering both female sex categories together, the proportion of females diagnosed with these immune conditions was slightly greater than when compared to the aggregate male data. A 1999 review by Pedersen reported the greatest prevalence of immune conditions occurred in intact females and the lowest with intact males [32] an assertion supported by the human literature [46] although those previous reports focused solely on intact individuals. In the canine literature, diagnoses of atopic dermatitis [47], CMG [20], IBD [48], lupus erythematosus [49], and PEMC [50] do not exhibit sex differences whereas for ADD, AIHA, IMPA, and ITP females have approximately a twofold higher risk than males [24, 51, 52].…”

Section: Discussionmentioning

confidence: 99%

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Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

et al. 2016

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BackgroundGonadectomy is one of the most common procedures performed on dogs in the United States. Neutering has been shown to reduce the risk for some diseases although recent reports suggest increased prevalence for structural disorders and some neoplasias. The relation between neuter status and autoimmune diseases has not been explored. This study evaluated the prevalence and risk of atopic dermatitis (ATOP), autoimmune hemolytic anemia (AIHA), canine myasthenia gravis (CMG), colitis (COL), hypoadrenocorticism (ADD), hypothyroidism (HYPO), immune-mediated polyarthritis (IMPA), immune-mediated thrombocytopenia (ITP), inflammatory bowel disease (IBD), lupus erythematosus (LUP), and pemphigus complex (PEMC), for intact females, intact males, neutered females, and neutered males. Pyometra (PYO) was evaluated as a control condition.ResultsPatient records (90,090) from the William R. Pritchard Veterinary Medical Teaching Hospital at the University of California, Davis from 1995 to 2010 were analyzed in order to determine the risk of immune-mediated disease relative to neuter status in dogs. Neutered dogs had a significantly greater risk of ATOP, AIHA, ADD, HYPO, ITP, and IBD than intact dogs with neutered females being at greater risk than neutered males for all but AIHA and ADD. Neutered females, but not males, had a significantly greater risk of LUP than intact females. Pyometra was a greater risk for intact females.ConclusionsThe data underscore the importance of sex steroids on immune function emphasizing a role of these hormones on tissue self-recognition. Neutering is critically important for population control, reduction of reproductive disorders, and offers convenience for owners. Despite these advantages, the analyses of the present study suggest that neutering is associated with increased risk for certain autoimmune disorders and underscore the need for owners to consult with their veterinary practitioner prior to neutering to evaluate possible benefits and risks associated with such a procedure.

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Section: Discussionmentioning

confidence: 99%

“…Lupus erythematosus included diagnoses of both systemic lupus erythematosus (SLE) and discoid lupus erythematosus (DLE) based upon the view that DLE is a localized presentation of SLE [32]. Pyometra (PYO) was used as a positive control; pyometras recorded for neutered females were stump pyometras.…”

Section: Methodsmentioning

confidence: 99%

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

et al. 2016

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“…It seems to be a problem of civilization connected with rising environmental pollution. The fact that our pets spend much more time indoors exposed to dust mite antigens is also a possible reason for the increased prevalence of atopic dermatitis (Pedersen 1999). In the field of human medicine, the 'hygiene hypothesis' and 'western' life style contribute to the allergic immunological profile (Th2 lymphocytes domination) (Lasek 2005;Roosje 2005).…”

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confidence: 99%

Cells of the skin immune system in dogs with atopy

et al. 2011

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Twenty-five dogs with signs of atopic dermatitis were included in this study. Additionally, 10 healthy dogs were chosen as healthy skin controls. Skin biopsy specimens were taken from these dogs and evaluated for the following cells: basal cell layer including the number of mitotic figures in this layer, spinous cell layer, macrophages, melanocytes, mast cells and dendritic cells. Identification of mast cells and dendritic cells was performed by means of immunohistochemistry. Histological and statistical investigations showed that the number of mitotic figures in the basal cell layer as well as the number of mast cells, melanocytes, dendritic cells and macrophages was significantly higher in the skin of dogs with atopic dermatitis compared to the healthy dogs (p < 0.01). This finding indicates multilateral quantitative activation within the cellular elements of the skin immune system. Furthermore, marked morphological heterogeneity and distinct degranulation patterns observed among mast cells in atopic skin points to their significant functional activation and confirms that canine atopic dermatitis is still notably a mast cell-dependent disease.

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“…Επειδή η νό σος, σε αντίθεση με τον άνθρωπο, εμφανίζεται σπάνια στο σκΰλο, δεν υπάρχουν αξιόπιστα δεδομένα αναφορικά με την προδιάθεση ως προς τη φυλή και το φΰλο (Iwasaki et al 1995, Rivierre andOlivry 2004). Ορισμένοι, όμως, ερευ νητές αναφέρουν ότι τέτοια προδιάθεση έχει διαπιστωθεί στις φυλές Collie, Shetland sheepdog και Doberman pinscher (Pedersen 1999). Πρόκειται για δερματοπάθεια των νεαρών και νεαρών ενήλικων κυρίως ζώων, η κλινι κή εικόνα της οποίας χαρακτηρίζεται από φυσαλίδες, διαβρώσεις, έλκη και εφελκίδες, με κυρίες εντοπίσεις την εσωτερική επιφάνεια των πτερυγίων των αυτιών, την κοι λιακή χώρα, τις μασχάλες, τα βλεννογονοδερματικά όρια και το βλεννογόνο της στοματικής κοιλότητας (Pedersen 1999, Olivry and Chan 2001, Scott et al2001).…”

Section: πομφολυγωδες πεμφιγοειδεςunclassified

Contemporary aspects on the immunopathogenesis of autoimmune diseases of the epidermal basement membrane in the dog

Papadogiannakis

2017

J Hellenic Vet Med Soc

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Autoimmune diseases of the epidermal basement membrane are the result of the immune system self-activation against specific antigens of its essential structural elements. This group of skin diseases is characterized by the destruction of connecting bonds between the membrane zone and dermis, which eventually leads to the dermoepidermal separation and the formation of subepidermal vesicles and bullae. In this article, the immunopathogenesis and the clinical, histopathological and immunohistochemical features of each of these skin diseases are briefly reviewed. The autoimmune diseases of the canine epidermal basement membrane have been recently classified as bullous pemphigoid, mucous membrane pemphigoid, linear IgA dermatosis, epidermolysis bullosa acquisita and bullous systemic lupus erythematosus. Recent advances in immunopathological and molecular techniques have markedly facilitated the understanding of their pathogenesis, thus giving the opportunity for the development of new therapeutic strategies that may improve or eliminate the clinical signs.

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A review of immunologic diseases of the dog

Cited by 58 publications

References 289 publications

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

Gonadectomy effects on the risk of immune disorders in the dog: a retrospective study

Cells of the skin immune system in dogs with atopy

Contemporary aspects on the immunopathogenesis of autoimmune diseases of the epidermal basement membrane in the dog

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