2022
DOI: 10.3390/biom12030435
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A Review of In Vivo and Clinical Studies Applying Scaffolds and Cell Sheet Technology for Periodontal Ligament Regeneration

Abstract: Different approaches to develop engineered scaffolds for periodontal tissues regeneration have been proposed. In this review, innovations in stem cell technology and scaffolds engineering focused primarily on Periodontal Ligament (PDL) regeneration are discussed and analyzed based on results from pre-clinical in vivo studies and clinical trials. Most of those developments include the use of polymeric materials with different patterning and surface nanotopography and printing of complex and sophisticated multip… Show more

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Cited by 21 publications
(12 citation statements)
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“…The periodontal ligament connects the cementum to the alveolar bone in normal periodontal tissue. Since the periodontal ligament is an important structure involved in mastication, it should be regenerated at the same time as alveolar bone formation in periodontal tissue regeneration therapy [42]. When biomaterials that strongly regenerate bone are implanted, adhesion between the new bone and the root of the tooth (ankylosis) may be observed without formation of the periodontal ligament.…”
Section: Discussionmentioning
confidence: 99%
“…The periodontal ligament connects the cementum to the alveolar bone in normal periodontal tissue. Since the periodontal ligament is an important structure involved in mastication, it should be regenerated at the same time as alveolar bone formation in periodontal tissue regeneration therapy [42]. When biomaterials that strongly regenerate bone are implanted, adhesion between the new bone and the root of the tooth (ankylosis) may be observed without formation of the periodontal ligament.…”
Section: Discussionmentioning
confidence: 99%
“…Regroth was, for instance, clinically applied after being coupled with carbonated HAP granules (Kitamura et al, 2022). Studies have also been actively conducted on the utility of various cell sheets for periodontal tissue regeneration (Bousnaki, Beketova, & Kontonasaki, 2022; Onizuka & Iwata, 2019).…”
Section: Periodontal Tissue Regeneration In Dental Implant Therapymentioning
confidence: 99%
“…[5,6] The key to achieving functional periodontal regeneration lies in the sandwich structure of the alveolar bone-PDL-cementum complex, and the appropriate PDL-fiber orientation and functional bone-ligament interfaces become the principal barrier. [7,8] Currently, cell-based tissue engineering techniques have achieved great progress in the field of periodontal regeneration. Jiang et al fabricated an aligned nanofiber-embedded scaffold, which provided topographic cues and subsequently guided the oriented regeneration of the periodontium.…”
Section: Introductionmentioning
confidence: 99%
“…However, due to the heavy demand of tissue sources to produce dECM bioink, the PDL, with a thickness of only 300 µm, does not have adequate material to serve as a source. [ 8 ] As the precursor of periodontal tissue, dental follicles eventually develop into periodontal structures during tissue differentiation and maturation, providing a beneficial periodontal microenvironment. [ 25 , 26 ] Moreover, dental follicle tissue is more integrated and larger in size, and there is more tissue to serve as a source for bioink.…”
Section: Introductionmentioning
confidence: 99%