“…Case studies provided a comprehensive clinical picture of pink disease long before its etiology was established. The most commonly reported symptoms included: irritability, neurosis, photophobia (light sensitivity), hyperhidrosis (excessive sweating), hypotonia (low muscle tone), ataxia (lack of coordination), digestive problems (including loss of weight, loss of appetite, vomiting, and constipation), anemia, excessive salivation, respiratory problems, lethargy, extreme misery, slurring/lossof speech, loosening/loss of teeth, swollen extremities, and perhaps most famously (and from which the name “pink disease” was derived), marked reddening of the extremities, particularly the hands and feet ( Rocaz 1933 ; Wood and Wood 1935 ; Leys 1950 ). Fatality was reasonably high, with death resulting in 10–33% of cases ( Rocaz 1933 ).…”