A Review of Interventional Radiology Treatments for Chronic Pain

McKnight, Kyle H.; Bagla, Sandeep; Dixon, Robert G.; Isaacson, Ari J.

doi:10.1016/j.jradnu.2020.06.010

Cited by 2 publications

(3 citation statements)

References 36 publications

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“…The scope of IR has evolved dramatically. In recent years, IR procedures have become relevant to alleviate chronic pain 27 associated with a life-limiting illness. Due to the rapid advancement of technology in medicine, there is a significant shift from conventional to minimally-invasive therapies.…”

Section: Role Of Interventional Radiology (Ir) In Palliative Carementioning

confidence: 99%

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Palliative care and interventional radiology for older adults during the COVID-19 pandemic

Angcahan

Guzman

2022

Journal of Medical Imaging and Radiation Sciences

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Section: Role Of Interventional Radiology (Ir) In Palliative Carementioning

confidence: 99%

“…The scope of IR has evolved dramatically. In recent years, IR procedures have become relevant to alleviate chronic pain (McKnight, et al, 2020) associated with a life-limiting illness.…”

Section: Role Of Interventional Radiology (Ir) In Palliative Carementioning

confidence: 99%

Palliative care and interventional radiology for older adults during the COVID-19 pandemic

Angcahan

Guzman

2022

Journal of Medical Imaging and Radiation Sciences

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“…Fine Tuning Periganglionic or Intraganglionic Routes of Administration Preclinical swine models are preferred in cases when the injection technique and/or anatomical precision is critical to the success of an experimental therapy. Recent advances have led to an increase in needle guidance and precision medicine technologies to deliver local analgesics and lesioning agents (Wood et al, 2007;McKnight et al, 2020). As the capability to deliver injections directly into the DRG grows, RTX stands out as an ideal candidate for injection in or around the ganglion.…”

Section: Swine Model For Interventional Analgesicsmentioning

confidence: 99%

Pain Treatment in the Companion Canine Model to Validate Rodent Results and Incentivize the Transition to Human Clinical Trials

Iadarola

Brown

Nahama³

et al. 2021

Front. Pharmacol.

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One of the biggest challenges for analgesic drug development is how to decide if a potential analgesic candidate will work in humans. What preclinical data are the most convincing, incentivizing and most predictive of success? Such a predicament is not unique to analgesics, and the pain field has certain advantages over drug development efforts in areas like neuropsychiatry where the etiological origins are either unknown or difficult to ascertain. For pain, the origin of the problem frequently is known, and the causative peripheral tissue insult might be observable. The main conundrum centers around evaluation of translational cell- and rodent-based results. While cell and rodent models are undeniably important first steps for screening, probing mechanism of action, and understanding factors of adsorption, distribution metabolism and excretion, two questions arise from such studies. First, are they reliable indicators of analgesic performance of a candidate drug in human acute and chronic pain? Second, what additional model systems might be capable of increasing translational confidence? We address this second question by assessing, primarily, the companion canine model, which can provide particularly strong predictive information for candidate analgesic agents in humans. This statement is mainly derived from our studies with resiniferatoxin (RTX) a potent TRPV1 agonist but also from protein therapeutics using a conjugate of Substance P and saporin. Our experience, to date, is that rodent models might be very well suited for acute pain translation, but companion canine models, and other large animal studies, can augment initial discovery research using rodent models for neuropathic or chronic pain. The larger animal models also provide strong translational predictive capacity for analgesic performance in humans, better predict dosing parameters for human trials and provide insight into behavior changes (bladder, bowel, mood, etc.) that are not readily assessed in laboratory animals. They are, however, not without problems that can be encountered with any experimental drug treatment or clinical trial. It also is important to recognize that pain treatment is a major veterinary concern and is an intrinsically worthwhile endeavor for animals as well as humans.

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A Review of Interventional Radiology Treatments for Chronic Pain

Cited by 2 publications

References 36 publications

Palliative care and interventional radiology for older adults during the COVID-19 pandemic

Palliative care and interventional radiology for older adults during the COVID-19 pandemic

Pain Treatment in the Companion Canine Model to Validate Rodent Results and Incentivize the Transition to Human Clinical Trials

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