A Review of Interventions to Enhance HIV Medication Adherence

Whiteley, Laura; Olsen, Elizabeth; Haubrick, Kayla K; Odoom, Enyonam; Tarantino, Nicholas; Brown, Larry K.

doi:10.1007/s11904-021-00568-9

Cited by 47 publications

(30 citation statements)

References 109 publications

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“…Based on these findings we can conclude that although several studies have demonstrated that MAEIs may improve clinical outcomes (Salema et al, 2011;Nieuwlaat et al, 2014;van Driel et al, 2016;Blakey et al, 2018;Godinho et al, 2020;Zijp et al, 2020;Gohil et al, 2021;Whiteley et al, 2021), existing evidence on the economic aspects of MAEIs is of poor quality (Elliott et al, 2005). Heterogeneity in the results of economic evaluations within different intervention types is significant due to disparity in the nature of interventions, investigated outcomes, the measures of non-adherence used and time horizons of studies, which makes comparing findings challenging.…”

Section: Reimbursed Medication Adherence Enhancing Interventionsmentioning

confidence: 98%

“…Several medication adherence enhancing interventions (MAEIs) -including many innovative technologies (e.g., smart devices, mobile applications) -have been developed in the last decade which may greatly improve suboptimal adherence to therapies and hence, therapeutic outcomes (Salema et al, 2011;Nieuwlaat et al, 2014;Costa et al, 2015;van Driel et al, 2016;Blakey et al, 2018;Godinho et al, 2020;Zijp et al, 2020;Gohil et al, 2021;Whiteley et al, 2021). The need for these technologies became increasingly important during the COVID-19 pandemic (Agh et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

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Reimbursed Medication Adherence Enhancing Interventions in European Countries: Results of the EUREcA Study

et al. 2022

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Introduction: Current literature lacks detailed understanding of the reimbursement framework of medication adherence enhancing interventions (MAEIs). As part of the ENABLE COST Action, the EUREcA (“EUropen REimbursement strategies for interventions targeting medication Adherence”) study aimed to provide an in-depth overview of reimbursed MAEIs currently available in European countries at national and regional levels and to pave the way for further MAEIs to be implemented in the future.Methods: A web-based, cross-sectional survey was performed across 38 European countries and Israel. The survey questionnaire was developed as a result of an iterative process of discussion informed by a desk review. The survey was performed among invited ENABLE collaborators from June to July 2021. Besides descriptive analysis, association between country income and health care expenditure, and the availability of reimbursed MAEIs were also assessed.Results: The survey identified 13 reimbursed MAEIs in nine countries: multi-dose drug dispensing (n = 5), medication review (n = 4), smart device (n = 2), mobile application (n = 1), and patient education (n = 1). The median GDP per capita of countries having ≥1 reimbursed MAEI was significantly higher compared to countries having no reimbursed adherence intervention (33,888 EUR vs 16,620 EUR, respectively; p = 0.05).Conclusions: Our findings highlight that to date only a small number of MAEIs have been reimbursed in European countries. Comprehensive health technology assessment recommendations and multi-stakeholder collaboration could help removing barriers related to the implementation and reimbursement of MAEIs.

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Section: Reimbursed Medication Adherence Enhancing Interventionsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Reimbursed Medication Adherence Enhancing Interventions in European Countries: Results of the EUREcA Study

et al. 2022

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“…Component B (pre-adherence skill building) was the last component delivered to participants and showed satisfactory levels of acceptability and feasibility. The need for and utility of memory aids such as alarms and reminders, and of pill boxes, are well established in the eld [59]. Yet, participants found these aspects of the component to be novel and also helpful.…”

Section: Discussionmentioning

confidence: 99%

Exploring intervention components grounded in critical race theory, harm reduction, and self-determination theory: A qualitative study with Black and Latino persons living with HIV in the United States

Cluesman

Gwadz

2022

Preprint

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Background . The persistence of racial/ethnic disparities in the United States in rates of engagement along the HIV care continuum signals the need for novel approaches. We recently described a new integrated conceptual model (ICM) that combines critical race theory, harm reduction, and self-determination theory. This ICM guided the development of six behavioral intervention components tested in optimization trial (Core component, Component A: motivational interviewing sessions, Component B: pre-adherence skill building, Component C: peer mentorship, Component D: focused support groups, Component E: navigation). The present qualitative exploratory study describes participants’ perspectives on the components’ acceptability, feasibility, and impact. Methods . Participants were African American/Black and Latino PLWH poorly engaged in HIV care and with non-suppressed HIV viral load in New York City. From a larger optimization trial (N = 512), we randomly selected 46 participants for in-depth semi-structured interviews. Interviews were audio-recorded and transcribed verbatim, and data were analyzed using directed content analysis. Structured data on components’ acceptability and feasibility were collected. Results . On average, participants were 49 years old (SD = 9) and had lived with HIV for 19 years (SD = 7). Most were male (78%) and African American/Black (76%). Participants reported a constellation of serious mainly social and structural challenges to HIV management including chronic poverty, unstable housing, and stigma. Components were found acceptable (> 70% rated them as quite a bit to very helpful). Feasibility was high: attendance rates for each component was > 80%. For all components, a non-judgmental, pressure-free, and structurally and culturally salient approach was seen as vital and described as lacking in most medical/social service settings. Prominent aspects of components, consistent with the ICM, included establishing trust (core); developing intrinsic motivation and self-reflection (Component A); learning/practicing adherence strategies and habits (Component B); reducing social isolation via peer role models (Component C); reflecting on salient goals and challenges with peers without stigma (Component D); and circumventing structural barriers to HIV management, including related to systemic racism (Component E). Conclusions . The ICM has potential to improve the acceptability and feasibility of interventions and services for AABL-PLWH, key underpinnings of intervention/treatment effectiveness. Future study of the ICM is warranted to address racial/ethnic health disparities.

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“…Evidence from meta-analyses and systematic reviews show that psychosocial interventions are an effective approach to improving ART adherence [12]. Formal and informal institutions play important roles in improving HIV treatment adherence [13].…”

Section: Discussionmentioning

confidence: 99%

Healthcare Providers’ Perspectives and Role in Improving Patient Engagement in HIV Treatment and Care in Almaty, Kazakhstan

King

Kussainova

Erlon-Baurjan

et al. 2021

IJERPH

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The HIV epidemic continues to grow in Eastern Europe and Central Asia. At the same time, there are major gaps in engagement in HIV treatment and care among people living with HIV (PLHIV) in the region, including Kazakhstan. Healthcare providers may have the potential to improve patients’ initiation of and adherence to HIV treatment; however, their perspectives and experiences are often overlooked in the research from Kazakhstan. The purpose of our study was to gain an in-depth understanding of how providers perceive the factors influencing PLHIV’s engagement in HIV treatment and care and to identify opportunities for expanding the role that providers can have in improving patient initiation and adherence to treatment in Kazakhstan. Through purposive sampling, we conducted in-depth interviews with 14 healthcare providers at the City AIDS Center in Almaty. We used team-based coding and thematic analysis in order to analyze the data. Quotes from providers were translated from Kazakh and Russian to English to illustrate the themes. Our results show that providers currently view their role as the need to break down myths around ART medications, and to educate and motivate patients to accept their diagnosis and learn to live with HIV. The need to address stigma and social isolation among PLHIV, the risk of overworked providers, and the need to improve patient-provider communication strategies are areas to consider for further interventions. Patient-provider communication interventions are needed in Kazakhstan in order to help meet the country’s 90-90-90 HIV targets.

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A Review of Interventions to Enhance HIV Medication Adherence

Cited by 47 publications

References 109 publications

Reimbursed Medication Adherence Enhancing Interventions in European Countries: Results of the EUREcA Study

Reimbursed Medication Adherence Enhancing Interventions in European Countries: Results of the EUREcA Study

Exploring intervention components grounded in critical race theory, harm reduction, and self-determination theory: A qualitative study with Black and Latino persons living with HIV in the United States

Healthcare Providers’ Perspectives and Role in Improving Patient Engagement in HIV Treatment and Care in Almaty, Kazakhstan

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