A review of invasive lobular carcinoma of the breast: Should it be treated like invasive ductal carcinoma?

Xin, Lee Joycelyn Jie; Eng, Lee Guek

doi:10.15761/icst.1000211

Cited by 2 publications

(1 citation statement)

References 62 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among semiquantitative parameters, 18 F-FES had significantly higher SUVmax and T/N ratio than 18 F-FDG PET/CT in lesions of ILC cell type, due to mostly strong ER expression (Xin and Eng 2016 ), low tumor density, low GLUT-1 expression, low proliferation rates, and infiltrative growth patterns (Fujii et al 2016 ). 18 F-FES PET/CT also had a significantly higher SUVmax and T/N ratio for Allred score 7–8 and Luminal A subtype.…”

Section: Discussionmentioning

confidence: 99%

Head-to-head comparison of 18F-FDG and 18F-FES PET/CT for initial staging of ER-positive breast cancer patients

Kiatkittikul,

Mayurasakorn,

Promteangtrong

et al. 2023

European J Hybrid Imaging

View full text Add to dashboard Cite

Purpose To compare the diagnostic performance of 18F-fluorodeoxyglucose (18F-FDG) and 18F-fluoroestradiol (18F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer. Methods Twenty-eight patients with ER-positive breast cancer underwent 18F-FDG and 18F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed for both radiotracers. Semiquantitative parameters of maximum standardized uptake value (SUVmax) and tumor-to-normal ratio (T/N ratio) were compared using Wilcoxon signed-rank test. Factors potentially affecting the degree of radiotracer uptake were analyzed by multi-level linear regression analysis. Results The overall diagnostic performance of 18F-FES was comparable to 18F-FDG, except for higher specificity and NPV, with sensitivity, specificity, PPV, NPV, and accuracy of 87.56%, 100%, 100%, 35.14%, and 88.35%, respectively, for 18F-FES and 83.94%, 30.77%, 94.74%, 11.43%, and 95.37%, respectively, for 18F-FDG. Diagnostic performance of strong ER expression was better in 18F-FES but worse for 18F-FDG. There was a correlation of mucinous cell type and Allred score 7–8 with 18F-FES uptake, with correlation coefficients of 26.65 (19.28, 34.02), 5.90 (− 0.005, 11.81), and p-value of < 0.001, 0.05, respectively. Meanwhile, luminal B and Ki-67 were related to 18F-FDG uptake, with correlation coefficients of 2.76 (1.10, 0.20), 0.11 (0.01, 0.2), and p-value of 0.018, 0.025, respectively. Conclusion Diagnostic performance of 18F-FES is comparable to 18F-FDG, but better for strongly ER-positive breast cancer. Combination of 18F-FES and 18F-FDG would potentially overcome the limitations of each tracer with more accurate staging.

show abstract

Section: Discussionmentioning

confidence: 99%